What Is Turkey Tail

Turkey tail may boost stamina and fight fatigue to enhance athletic performance. A study using animal models found that turkey tail extract increased endurance and strength in mice. Moreover, the extract reduced physical fatigue in the mice and lowered blood sugar levels at rest and after exercise.

5 Immune-Boosting Benefits of Turkey Tail Mushroom

Turkey tail is a medicinal mushroom that’s full of antioxidants and other compounds. Evidence shows it may help fortify your immune system, maintain healthy gut bacteria, and support the treatment of some cancers.

Medicinal mushrooms are types of fungi that contain compounds known to benefit health.

While there is an abundance of mushrooms with medicinal properties, one of the most well-known is Trametes versicolor, also known as Coriolus versicolor.

Commonly called turkey tail due to its striking colors, Trametes versicolor has been used around the world for centuries to treat various conditions.

Perhaps the most impressive quality of the turkey tail mushroom is its ability to enhance the health of your immune system.

In studies, the artificial intelligence (AI) technology used in some online health services for preliminary screening before connecting patients with a doctor actually outperformed real physicians in terms of reaching an accurate diagnosis, CNN AI technology correctly diagnosed conditions in 81% of patients, compared to a 72% average for accurate diagnoses among real physicians over a five-year period.

Here are 5 immune-boosting benefits of the turkey tail mushroom.

Antioxidants are compounds that help inhibit or reduce damage caused by oxidative stress.

Oxidative stress results from an imbalance between antioxidants and unstable molecules known as free radicals. This can result in cellular damage and chronic inflammation ( 1 ).

This imbalance has also been linked to an increased risk of developing health conditions, such as certain cancers and heart disease ( 2 , 3 ).

Thankfully, eating foods rich in antioxidants or supplementing with these powerful compounds can reduce oxidative stress and inflammation.

Turkey tail contains an impressive array of antioxidants, including phenols and flavonoids ( 4 ).

In fact, one study detected over 35 different phenolic compounds in a sample of turkey tail mushroom extract, along with the flavonoid antioxidants quercetin and baicalein ( 5 ).

Phenol and flavonoid antioxidants promote immune system health by reducing inflammation and stimulating the release of protective compounds ( 6 ).

For example, quercetin has been shown to promote the release of immunoprotective proteins like interferon-y, while inhibiting the release of the pro-inflammatory enzymes cyclooxygenase (COX) and lipoxygenase (LOX) ( 7 ).

Summary

Turkey tail contains a wide variety of phenol and flavonoid antioxidants which help promote your immune system health by reducing inflammation and stimulating the release of protective compounds.

Turkey tail also contains polysaccharopeptides, which are protein-bound polysaccharides (carbohydrates).

Krestin (PSK) and Polysaccharide Peptide (PSP) are two types of polysaccharopeptides found in turkey tails ( 8 ).

They promote immune response by both activating and inhibiting specific types of immune cells and by suppressing inflammation.

For instance, test-tube studies have demonstrated that PSP increases monocytes, which are types of white blood cells that fight infection and boost immunity ( 9 ).

PSK stimulates dendritic cells, which promote immunity to toxins, and regulate the immune response. In addition, PSK activates natural killer cells, a type of white blood cell that helps protect against pathogens and cancerous tumors ( 10 ).

Due to their ability to naturally strengthen the immune system, PSP and PSK are commonly used as anticancer agents in conjunction with surgery, chemotherapy, radiation, or a combination of these treatments in countries like Japan and China ( 11 ).

Summary

PSPs are powerful polysaccharopeptides found in turkey tail mushrooms that may strengthen the health of your immune system.

Research has demonstrated that turkey tail may have antitumor properties, thought to be related to its immune-boosting effects.

One test-tube study found that PSK, the polysaccharopeptide found in turkey tail mushrooms, inhibited the growth and spread of human colon cancer cells ( 12 ).

What’s more, a certain type of polysaccharide found in turkey tail called Coriolus versicolor glucan (CVG) may suppress certain tumors.

A study in tumor-bearing mice found that treatment with 45.5 and 90.9 milligrams (mg) per pound or 100 and 200 mg per kilogram (kg) of body weight of CVG extracted from turkey tail mushrooms daily significantly reduced tumor size ( 13 ).

Researchers attributed this development to enhanced immune response ( 13 ).

A systematic review and meta-analysis also found that PSK from turkey tail may improve survival rates in people with colorectal or intestinal cancer, especially when combined with chemotherapy ( 14 ). That said, some studies have shown inconclusive results ( 15 , 16 , 17 ).

Summary

Turkey tail mushrooms contain components such as PSK and CVG that may suppress the growth of certain types of cancers.

Keeping a healthy balance of beneficial bacteria in your gut is critical for maintaining a strong immune system.

Your gut bacteria interact with immune cells and directly impact your immune response ( 18 ).

Turkey tail contains prebiotics, which help nourish these helpful bacteria. Research studies have found that treatment with turkey tail can have a similarly positive effect on the gut microbiome as treatment with prebiotic supplements (19).

For example, a test-tube study found that turkey tail extract modified gut bacteria composition by increasing populations of beneficial bacteria like Bifidobacterium and Lactobacillus while reducing potentially harmful bacteria, such as Clostridium and Staphylococcus ( 20 ).

Having healthy levels of Lactobacillus and Bifidobacterium bacteria has been linked to improved intestinal symptoms like diarrhea, enhanced immune system, reduced cholesterol levels, lower risks of certain cancers, and improved digestion ( 21 ).

Summary

Turkey tail mushroom may positively impact gut bacterial balance by enhancing the growth of beneficial bacteria while suppressing harmful species.

Aside from the benefits listed above, turkey tail may promote health in other ways as well:

• May combat HPV: A study of 91 women with a Human Papillomavirus (HPV) infection found that 84.9% of those treated with a turkey tail-based vaginal gel had a normal pap smear and colposcopy 6 months after treatment. This compared to 64.5% of those who didn’t use the gel. In addition, 59.6% of women treated were completely cleared of the virus compared to 41.9% of those who weren’t (22).
• Has antibacterial qualities: In a test-tube study, turkey tail extract inhibited the growth of Staphylococcus aureus and Salmonella enterica, bacteria that can cause illness and infection ( 23 ).
• May improve athletic performance: A mouse study showed that turkey tail extract improved exercise performance and reduced markers of fatigue. Plus, the mice treated with turkey tail experienced lower blood sugar levels at rest and post-exercise ( 24 ).
• May improve insulin resistance: A study in rats with type 2 diabetes demonstrated that turkey tail extract significantly reduced blood sugar levels and improved insulin resistance ( 25 ).

Research studies on turkey tail mushroom are ongoing and more benefits of this medicinal mushroom may be discovered in the near future.

Summary

Tail mushroom may improve insulin resistance, help fight pathogenic bacteria, reduce inflammation, treat HPV, and boost exercise performance.

Turkey tail mushroom is considered safe, with few side effects reported in research studies.

Some people may experience digestive symptoms like gas, bloating, and dark stools when taking turkey tail mushroom.

When used as a cancer treatment alongside chemotherapy, side effects including nausea, vomiting, and loss of appetite have been reported ( 26 ).

However, it’s unclear if those side effects were related to turkey tail mushroom or the conventional cancer treatments being used (27).

Another potential side effect of consuming turkey tail mushroom is the darkening of the fingernails ( 28 ).

Even though it has a good safety profile, it’s important to speak with your doctor before supplementing with turkey tail mushroom.

Summary

Turkey tail mushroom may result in side effects, such as diarrhea, gas, dark fingernails and vomiting.

Turkey tail is a medicinal mushroom with an impressive range of benefits.

It contains a variety of powerful antioxidants and other compounds that may help boost your immune system and even help fight certain cancers.

Plus, turkey tail may improve gut bacteria balance, which can positively impact your immunity.

With all its immune-boosting qualities, it’s no wonder turkey tail is a popular natural treatment to promote health.

Last medically reviewed on April 6, 2023

How we reviewed this article:

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

What Is Turkey Tail?

Lindsay Curtis is a health writer with over 20 years of experience in writing health, science & wellness-focused articles.

Published on December 23, 2022

Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, herbalist, and integrative medicine doctor practicing in Santa Monica, California.

Table of Contents
Table of Contents

Turkey tail (Trametes versicolor or Coriolus versicolor) is a medicinal mushroom used for hundreds of years to treat various health conditions. Long used in traditional Chinese medicine, turkey tail is packed with antioxidants and other health-boosting compounds.

When taken as a supplement, turkey tail benefits may include the following:

• Boosted immunity
• Improved cognitive function
• Increased exercise performance
• Improved gut health
• Reduced inflammation
• Lower blood sugar in people with type 2 diabetes

This article discusses the potential uses and benefits of turkey tail. It also covers potential side effects and what to look for when purchasing turkey tail supplements.

Dietary supplements are not regulated the way drugs are in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Choose a supplement tested by a trusted third party, such as USP, ConsumerLabs, or NSF, when possible.

However, even if supplements are third-party tested, it doesn’t mean they are necessarily safe for all or effective in general. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications.

Catherine McQueen / Getty Images

Supplement Facts

• Active ingredient(s): Polysaccharides, antioxidants, beta-glucan, sterols, fatty acids, phenolic compounds
• Alternate name(s):Tramates versicolor, Coriolus versicolor, Yun Zhi, turkey tail fungus, cloud mushroom, and kawaratake
• Legal status: Legal, available over the counter (OTC)
• Suggested dose: Dosage depends on the reason for use
• Safety considerations: Turkey tail mushroom is safe and generally well-tolerated, but it’s not recommended for use while pregnant or breastfeeding.

Uses of Turkey Tail

Supplement use should be suited to the individual and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent disease.

Turkey tail has well-documented uses for supporting immune function, reducing inflammation, improving gut health, and enhancing the efficacy of cancer treatments.

Researchers are exploring how turkey tail may help balance blood sugar levels, boost athletic performance, fight viral and bacterial infections, and reduce fatigue. Some proponents of turkey tail believe it can prevent urinary tract infections (UTIs) and protect against age-related cognitive decline.

Many studies investigating the potential medicinal benefits of turkey tail have been conducted using animal models or in lab settings. More clinical research is needed to determine the specific uses of turkey tail for human health.

Promotes Immune Health

Turkey tail contains a high concentration of two polysaccharides with immune-boosting properties: polysaccharide-K (krestin, or PSK) and polysaccharide peptides (PSP). PSK and PSP are immunomodulators that stimulate and balance the immune system to help the body fight infection, cancer, and other diseases.

PSPs stimulate immune cell production to help fight and protect against infection. Research suggests that PSPs may promote the growth of monocytes—a type of white blood cell that fights infection and improves immunity.

Similarly, PSK helps support the immune system by activating the body’s natural killer cells to fight off infection and disease. It has also been shown to modulate the body’s immune response by suppressing inflammation, which may help protect against inflammatory diseases.

Adjuvant Therapy for Cancer

Turkey tail extracts have been used in Japan for decades as an adjuvant (additional) therapy for cancer treatments. These extracts are often combined with chemotherapy or radiation therapy to boost the efficacy of these treatments and improve outcomes.

A review of 13 clinical trials found that cancer patients given turkey tail in combination with standard treatments lived longer than those who received chemotherapy alone. The combination of turkey tail and chemotherapy was especially effective in improving outcomes for people with breast cancer, gastric cancer, and colorectal cancer.

Other studies have shown that turkey tail extracts not only inhibit the growth of some cancer cells but also improve immune function in people with certain cancers, which may reduce the risk of infection.

Supports Gut Health

Turkey tail may improve gut health by promoting the growth of beneficial bacteria that support healthy digestion. Turkey tail acts as a prebiotic, stimulating the development of “good” bacteria in the gut microbiome. Having a healthy, balanced gut microbiome is linked to improved digestive health, a strong immune system, and a lower risk of gastrointestinal disorders and diseases,

In one small study, participants were given 3,600 milligrams (mg) of turkey tail PSP extract per day over eight weeks. Results showed that turkey tail extract increased the number of beneficial bacteria and suppressed the growth of potentially harmful bacteria.

An earlier test-tube study found that turkey tail extract significantly increased the number of helpful bacteria, such as Bifidobacterium and Lactobacillus, while reducing populations of “bad” bacteria, such as Clostridium and Enterococcus.

May Boost Athletic Performance

Turkey tail may boost stamina and fight fatigue to enhance athletic performance. A study using animal models found that turkey tail extract increased endurance and strength in mice. Moreover, the extract reduced physical fatigue in the mice and lowered blood sugar levels at rest and after exercise.

Human trials are needed to determine what benefits turkey tail may offer athletes regarding endurance, strength, energy levels, and recovery.

Other Benefits

In addition to the health benefits listed above, some people use turkey tail to support:

• Bone health: Animal model research found that turkey tail extract resulted in thicker, less porous bones and may protect against bone loss related to certain cancer treatments.
• Cognitive function: Turkey tail is rich in antioxidants, which may improve cognitive function (e.g., memory, problem-solving) and reduce the risk of age-related cognitive decline.
• Healthy aging: The antioxidants and immune-boosting properties of turkey tail may help support health and protect against inflammation and age-related diseases.
• Balanced blood sugar levels: Studies using animal models show that turkey tail extracts may reduce blood sugar levels, improve insulin resistance, and prevent diabetes-related complications in people with type 2 diabetes.

What Are the Side Effects of Turkey Tail?

Turkey tail is safe to consume and generally well-tolerated, but some people may experience mild side effects, including:

• Bloating
• Dark stools
• Darkening of the fingernails
• Gas
• Heartburn

Although turkey tail is safe for most people, it’s important to speak with your healthcare provider before taking a turkey tail mushroom supplement.

Precautions

Avoid taking turkey tail supplements if you:

• Are pregnant or breastfeeding: No research has been conducted on the safety of turkey tail for pregnant or breastfeeding people.
• Have diabetes: Turkey tail may lower blood sugar levels and cause levels to drop too low when taken with diabetes medications.
• Are allergic to mushrooms: Turkey tail is a fungus and should be avoided by anyone with mushroom or mold allergies.

Children should also avoid turkey tail, as its safety has not been studied in minors.

Dosage: How Much Turkey Tail Should I Take?

Always speak with a healthcare provider before taking turkey tail to ensure that the supplement and dosage are appropriate for your individual needs.

There are no guidelines for a standard turkey tail dose. Dosages vary widely in studies exploring the benefits of turkey tail extracts and supplements. For example, studies examining turkey tail as an adjuvant therapy for cancer have used 3–9 grams per dose.

Many turkey tail supplement manufacturers recommend starting with 1–3 grams daily to support overall health. Supplement doses vary by product, so read the manufacturer’s supplement facts on the product label or speak with a healthcare professional to determine the best product and dose for you.

What Happens If I Take Too Much Turkey Tail?

Turkey tail is safe for consumption when taken as directed. No reports of overdose have been documented. However, there are concerns that wild-grown medicinal mushrooms can accumulate heavy metals such as mercury, lead, cadmium, and arsenic. These metals can pose health risks when too much is consumed.

More research is needed on the long-term safety of turkey tail. Take only the recommended dose on the product label, and consult your healthcare provider for guidance on dosing and supplement type.

Interactions

Certain medications may interact with turkey tail mushrooms, including:

• Certain anticancer drugs: Compounds found in turkey tail mushrooms can change how certain anticancer drugs (e.g., cyclophosphamide, tamoxifen) are processed and removed from the body, which may alter the efficacy of the anti-cancer drug and cause more side effects.
• Diabetes medications: Turkey tail mushrooms may lower blood sugar levels too much in people taking diabetes medications.
• Other herbs and supplements that lower blood sugar: Any herbs and supplements known to lower blood sugar (e.g., aloe, cassia cinnamon) should be avoided to prevent blood sugar levels from dropping too low.

Carefully read the ingredient list and nutrition facts panel of any turkey tail supplement you purchase to know which and how much of each ingredient is included. Review the supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications.

How to Store Turkey Tail

Store turkey tail in an airtight container in a cool, dry place away from direct sunlight. Some turkey tail tinctures or liquid extracts may need to be refrigerated. Follow storage directions on the product label. Discard turkey tail supplements once the expiration date listed on the label is reached.

Sources of Turkey Tail & What to Look For

Turkey tail mushrooms grow on dead logs, stumps, and branches in deciduous forests in Asia, Europe, and North America. Semicircular and fan-shaped with distinctive striped layers of brown, gray, tan, and white, the mushroom resembles the feathers of a turkey’s tail.

If you forage for wild-grown turkey tail, it’s important to be aware of other fungi species that look similar to turkey tail. Before harvesting, be sure you have correctly identified that the mushroom is turkey tail and not a look-alike.

Though turkey tail is edible, the texture can be described as tough and leathery. For this reason, wild-harvested turkey tail is usually dried, ground into a powder, and consumed as tea. It can also be added to soups or blended into smoothies. Dried whole turkey tail mushrooms can be used to make extracts and tinctures.

Turkey Tail Supplements

Turkey tail supplements are available in capsule, powder, and tincture forms.

Some turkey tail supplements contain the whole mushroom, including the fruit body and mycelium (root structure). The mushrooms are dried and then ground into powder. Other turkey tail supplements contain extracts of the mushroom’s beneficial compounds. These products provide a concentrated amount of health-supporting compounds with the full spectrum of health benefits.

When shopping for a high-quality supplement, look for the following:

• An ingredients label on the product packaging that clearly lists all ingredients contained in the supplement and the amount of each ingredient.
• Supplements made from organic, 100% fruiting bodies. These offer the highest amount of beneficial compounds. Skip the supplements that include mycelium (root structure of the mushroom), grain, or other fillers.
• Products tested by accredited third-party labs in the United States, such as U.S. Pharmacopeia (USP) and ConsumerLab. A quality assurance seal on the packaging from accredited labs is a sign that the product was manufactured properly, does not contain harmful contaminants, and includes the ingredients listed on the label.

Reading product reviews online can help ensure you purchase from a reputable manufacturer. Consult your healthcare provider for advice on finding the best supplement.

Summary

Turkey tail is a medicinal mushroom with a long history of use in traditional medicine. This fungus is found on dead tree stumps and logs around the world and has a tremendous range of potential health benefits. Turkey tail is packed with antioxidants and other health-promoting compounds that may help boost immunity, support gut health, reduce inflammation, and enhance the efficacy of standard cancer treatments.

Proponents of turkey tail suggest that the mushroom may enhance cognitive functioning, reduce fatigue, improve athletic performance, and protect against age-related diseases. Turkey tail is generally safe to consume with few side effects. Talk to your healthcare provider to determine if turkey tail supplements are right for you.

18 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

1. National Cancer Institute. Medicinal mushrooms (PDQ®)–health professional version.
2. Kıvrak I, Kivrak S, Karababa E. Assessment of bioactive compounds and antioxidant activity of turkey tail medicinal mushroom trametes versicolor (agaricomycetes).Int J Med Mushrooms. 2020;22(6):559-571. doi:10.1615/IntJMedMushrooms.2020035027
3. Claus-Desbonnet H, Nikly E, Nalbantova V, et al. Polysaccharides and their derivatives as potential antiviral molecules. Viruses. 2022;14(2):426. doi:10.3390/v14020426
4. Benson KF, Stamets P, Davis R, et al. The mycelium of the trametes versicolor (turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro. BMC Complement Altern Med. 2019;19(1):342. doi:10.1186/s12906-019-2681-7
5. Sekhon BK, Sze DM, Chan WK, et al. PSP activates monocytes in resting human peripheral blood mononuclear cells: immunomodulatory implications for cancer treatment. Food Chem. 2013;138(4):2201-2209. doi:10.1016/j.foodchem.2012.11.009
6. Maehara Y, Tsujitani S, Saeki H, et al. Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives. Surg Today. 2012;42(1):8-28. doi:10.1007/s00595-011-0075-7
7. Eliza WL, Fai CK, Chung LP. Efficacy of yun zhi (coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov. 2012;6(1):78-87. doi:10.2174/187221312798889310
8. National Cancer Institute. Medicinal mushrooms (PDQ®)–health professional version.
9. Rinninella E, Raoul P, Cintoni M, et al. What is the healthy gut microbiota composition? a changing ecosystem across age, environment, diet, and diseases. Microorganisms. 2019;7(1):14. doi:10.3390/microorganisms7010014
10. Pallav K, Dowd SE, Villafuerte J, et al. Effects of polysaccharopeptide from trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial. Gut Microbes. 2014;5(4):458-467. doi:10.4161/gmic.29558
11. Yu ZT, Liu B, Mukherjee P, et al. Trametes versicolor extract modifies human fecal microbiota composition in vitro. Plant Foods Hum Nutr. 2013;68(2):107-112. doi:10.1007/s11130-013-0342-4
12. Ho CS, Tung YT, Kung WM, et al. Effect of coriolus versicolor mycelia extract on exercise performance and physical fatigue in mice. Int J Med Sci. 2017;14(11):1110-1117. doi:10.7150/ijms.20547
13. Alzheimer’s Drug Discovery Foundation. Turkey tail mushroom.
14. Xian HM, Che H, Qin Y, et al. Coriolus versicolor aqueous extract ameliorates insulin resistance with PI3K/Akt and p38 MAPK signaling pathways involved in diabetic skeletal muscle. Phytother Res. 2018;32(3):551-560. doi:10.1002/ptr.6007
15. Lo HC, Hsu TH, Lee CH. Extracellular polysaccharopeptides from fermented turkey tail medicinal mushroom, trametes versicolor (agaricomycetes), mitigate oxidative stress, hyperglycemia, and hyperlipidemia in rats with type 2 diabetes mellitus. Int J Med Mushrooms. 2020;22(5):417-429. doi:10.1615/IntJMedMushrooms.2020034560
16. Fritz H, Kennedy DA, Ishii M, et al. Polysaccharide K and coriolus versicolor extracts for lung cancer: a systematic review. Integr Cancer Ther. 2015;14(3):201-211. doi:10.1177/1534735415572883
17. Susan G. Komen. Coriolus mushroom.
18. Sarikurkcu C, Yildiz D, Akata I, et al. Evaluation of the metal concentrations of wild mushroom species with their health risk assessments. Environ Sci Pollut Res Int. 2021;28(17):21437-21454. doi:10.1007/s11356-020-11685-0