STK11 gene

The STK11 gene, also known as LKB1, is a tumor suppressor gene that plays a critical role in preventing the formation of various types of cancer. This gene is associated with a condition called Peutz-Jeghers syndrome, which is characterized by the development of benign polyps in the digestive tract and an increased risk of developing certain types of cancer.

Research on the STK11 gene and its role in cancer has been extensively studied and documented. PubMed, a central database for scientific articles, lists numerous references and articles related to the genetic changes in this gene and its association with different types of cancer.

To determine if an individual has a variant in the STK11 gene and an increased risk of developing cancer, genetic testing can be conducted. This type of testing is typically only recommended for individuals who have a family history of Peutz-Jeghers syndrome or other related conditions.

In addition to the information available in scientific databases such as PubMed, there are several online resources, such as the Online Mendelian Inheritance in Man (OMIM) database, that provide additional information on the STK11 gene and related conditions.

Health Conditions Related to Genetic Changes

The STK11 gene, also known as the LKB1 gene, is a tumor suppressor gene. Changes in this gene can lead to a condition called Peutz-Jeghers syndrome.

Peutz-Jeghers syndrome is a rare genetic condition characterized by the development of polyps in the digestive tract and an increased risk of certain types of cancer, including breast, ovarian, and colon cancer. People with Peutz-Jeghers syndrome may also have pigmented spots on their lips, gums, and other parts of the body.

In addition to Peutz-Jeghers syndrome, changes in the STK11 gene have been associated with other health conditions and an increased risk of cancer. Some of these conditions are listed below:

  • Pancreatic cancer
  • Lung cancer
  • Testicular cancer
  • Thyroid cancer

Genetic testing can be done to identify changes in the STK11 gene and determine the risk of developing these conditions. This type of testing is often called somatic testing and can be done on tumor tissue samples.

In addition to genetic testing, there are other resources available for information on the STK11 gene and related conditions. These resources include scientific articles, databases such as PubMed and OMIM, and the Cancer Gene Census catalog, which provides information on genes associated with cancer.

It is important to note that changes in the STK11 gene are not the only genetic changes that can increase the risk of these health conditions. There are other genes and genetic changes that can also contribute to the development of cancer.

References:

  1. Epub 2016 Oct 24. PubMed PMID: 27774284.
  2. OMIM database entry for LKB1 gene.
  3. Cancer Gene Census. Catalog of genes associated with cancer.

Breast cancer

Breast cancer is a type of cancer that originates in the breast tissue. It can occur in both men and women, although it is much more common in women. There are different types of breast cancer, including invasive ductal carcinoma and invasive lobular carcinoma.

The STK11 gene, also called LKB1, is a tumor suppressor gene that is involved in the development of breast cancer. Somatic changes in this gene can increase the risk for developing breast cancer.

Genetic testing can detect specific changes or variants in the STK11 gene that are associated with an increased risk for breast cancer. This testing can be done through scientific resources such as the Genetic Testing Registry and the Online Mendelian Inheritance in Man (OMIM) database.

Breast cancer is not the only condition associated with changes in the STK11 gene. Peutz-Jeghers syndrome, a genetic condition characterized by the development of polyps in the gastrointestinal tract and increased risk for other cancers, is also caused by changes in this gene.

In addition to breast cancer and Peutz-Jeghers syndrome, changes in the STK11 gene have also been linked to ovarian cancer, lung cancer, and other related conditions. Genetic testing for these conditions can be done through scientific resources and genetic testing laboratories.

The STK11 gene is listed in various scientific articles, and additional information can be found on PubMed, a central repository for scientific research articles.

In summary, breast cancer is a complex disease with genetic and environmental risk factors. The STK11 gene, also known as LKB1, is a tumor suppressor gene that plays a role in the development of breast cancer. Changes in this gene can also lead to other conditions, such as Peutz-Jeghers syndrome. Genetic testing can help identify individuals who may be at increased risk for breast cancer and other related conditions.

Peutz-Jeghers syndrome

Peutz-Jeghers syndrome (PJS) is a genetic condition characterized by the presence of hamartomatous polyps in the gastrointestinal tract and other parts of the body. It is caused by mutations in the STK11 gene, also known as the LKB1 gene.

PJS is an autosomal dominant syndrome, which means that inheriting a single copy of the mutated gene is enough to develop the condition. The presence of hamartomatous polyps is a key feature of this syndrome and can occur in multiple organs, including the intestines, stomach, and large bowel.

Individuals with PJS have an increased risk of developing various types of cancer, including gastrointestinal, breast, ovarian, lung, and other types of cancers. Tumor suppressor genes, such as STK11, normally regulate cell growth and division. When these genes are mutated, they can lose their ability to control cell growth, resulting in the development of cancerous cells.

Diagnosis of PJS is usually based on a combination of clinical findings, family history, and genetic testing. Genetic testing can identify mutations in the STK11 gene and confirm the diagnosis. However, not all cases of PJS have identifiable mutations, so genetic testing is not always definitive.

It is important for individuals with PJS to undergo regular surveillance for cancer and closely monitor their health. This may include regular screenings, such as colonoscopies and mammograms, to detect any early signs of cancer. Additional resources, such as the Peutz-Jeghers Syndrome Support Group and the Peutz-Jeghers Syndrome Registry, can provide support and information for individuals and families affected by this condition.

For additional information on PJS, genetic testing, and related conditions, scientific articles and resources can be found on databases such as PubMed and OMIM. These references can provide more in-depth information on the syndrome, STK11 gene, and other related genes and conditions.

Lung cancer

Lung cancer is a type of cancer that affects the lungs. It is one of the most common types of cancer worldwide and is often caused by a combination of genetic and environmental factors. One gene that is associated with an increased risk of developing lung cancer is the STK11 gene, also known as LKB1.

The STK11 gene is a tumor suppressor gene, which means that it helps regulate cell growth and prevent the formation of cancerous tumors. Mutations in the STK11 gene can lead to a condition called Peutz-Jeghers syndrome, which is characterized by the development of polyps in the digestive tract and an increased risk of developing certain types of cancers, including lung cancer.

Genetic testing for mutations in the STK11 gene can be done to determine the risk of developing lung cancer and other related conditions. This testing is often done in a clinical setting, such as a cancer registry or a specialized genetics clinic.

Additional information on the STK11 gene and its role in lung cancer can be found in scientific articles and databases such as PubMed and OMIM. These resources provide references to related research articles and information on genetic changes in the STK11 gene associated with lung cancer.

It is important to note that not all lung cancers are caused by mutations in the STK11 gene. Other somatic changes in genes and environmental factors can also contribute to the development of lung cancer. Central registries and databases for lung cancer testing can provide information on other genetic variants and related conditions.

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Testing for mutations in the STK11 gene and other related genes is available for certain individuals with a family history of lung cancer or other conditions associated with the gene. This type of testing can help identify individuals who may be at an increased risk of developing lung cancer and inform medical management strategies.

In conclusion, the STK11 gene, also known as LKB1, is a tumor suppressor gene that is associated with an increased risk of developing lung cancer and other related conditions. Genetic testing and central registries can provide valuable information on the genetic changes and risk associated with the gene, helping to inform medical decisions and management strategies.

Ovarian cancer

Ovarian cancer is a cancerous tumor that forms in the ovaries, which are the female reproductive organs responsible for producing eggs. This type of cancer can be caused by various factors, including genetic changes in the STK11 gene.

The STK11 gene, also known as LKB1, is a tumor suppressor gene that plays a role in preventing the growth and division of abnormal cells. Mutations in this gene can increase the risk of developing ovarian cancer and other related cancers, such as breast and lung cancer.

Genetic testing for mutations in the STK11 gene can be performed to assess the risk of developing ovarian cancer and other associated conditions. This testing can be done using somatic or germline testing methods. Somatic testing is used to detect genetic changes in the tumor itself, while germline testing looks for inherited genetic changes in the blood or saliva.

There are several resources and databases available for genetic testing and information on the STK11 gene and ovarian cancer. The OMIM (Online Mendelian Inheritance in Men) database provides scientific information on genes and genetic conditions, including ovarian cancer and the STK11 gene. PubMed, a central scientific database, catalogs articles and references related to ovarian cancer, genetic testing, and the STK11 gene.

In addition to genetic testing, there are other tests and screening methods available for detecting ovarian cancer. These include imaging tests such as ultrasound and CT scans, as well as blood tests to measure levels of certain substances that may be elevated in the presence of ovarian cancer.

For individuals with a family history of ovarian cancer or related conditions, genetic testing can provide important information about their risk and potential preventive measures. It is recommended that individuals consult with a healthcare professional or genetic counselor to discuss testing options and any additional resources available.

  • Genetic changes in the STK11 gene can increase the risk of ovarian cancer.
  • Genetic testing can help assess the risk of developing ovarian cancer.
  • Other tests and screening methods are available for detecting ovarian cancer.
  • Resources such as OMIM and PubMed provide scientific information on ovarian cancer and the STK11 gene.
  • Consulting with a healthcare professional or genetic counselor is recommended for individuals considering genetic testing.

Other cancers

The STK11 gene is also associated with an increased risk of developing other types of cancers, including ovarian, lung, and breast cancer.

Tests for mutations in the STK11 gene can be conducted to determine an individual’s risk for developing these cancers. These tests are usually performed in individuals who have a personal or family history of cancer.

The LKB1 protein, encoded by the STK11 gene, acts as a tumor suppressor and is involved in regulating cell growth and division. Changes or mutations in the STK11 gene can disrupt the normal function of the LKB1 protein, leading to the development of cancerous cells.

Individuals with the STK11 gene mutation are also at increased risk for developing a condition called Peutz-Jeghers syndrome, characterized by the growth of noncancerous polyps in the gastrointestinal tract. These polyps can increase the risk of developing various types of cancers, including gastrointestinal, pancreatic, and breast cancer.

For more scientific and genetic information on STK11 gene and related conditions, the following resources can be consulted:

  • Online Mendelian Inheritance in Man (OMIM) database
  • Genetics Home Reference
  • Cancer Genetics Registry
  • Epub ahead of print articles on PubMed
  • Testing laboratories that offer genetic testing for the syndrome

Genetic testing for the STK11 gene can provide valuable information regarding an individual’s risk for developing cancer and help in the management and prevention of associated conditions and diseases.

Other Names for This Gene

The STK11 gene, also known as the LKB1 gene, is a cancerous suppressor gene. It is associated with the Peutz-Jeghers syndrome (PJS), a genetic condition characterized by the development of hamartomatous polyps and an increased risk of various types of cancer, particularly in the colon, breast, ovary, and lung.

Here are some other names for the STK11 gene:

  • LKB1
  • PJS
  • serine/threonine kinase 11

Testing for variants in the STK11 gene can provide important information about a person’s risk for developing cancer and other related diseases. Genetic testing for STK11 gene changes can be done through various testing methods, including somatic testing and germline testing.

There are several resources available for information on the STK11 gene, including scientific articles, cancer registries, and genetic databases. These resources provide a wealth of information on the gene, its associated conditions, and testing options. Some of the resources include:

  1. The National Institutes of Health’s Genetic Testing Registry (GTR)
  2. The Online Mendelian Inheritance in Man (OMIM) catalog
  3. PubMed Central, a central hub for scientific articles

It is important to consult these resources and genetic healthcare professionals for accurate and up-to-date information on the STK11 gene and related conditions. Understanding the role of the STK11 gene in cancer development can help in the prevention, diagnosis, and treatment of cancer.

Additional Information Resources

  • The STK11 gene is associated with a genetic condition called Peutz-Jeghers syndrome. This syndrome is characterized by the development of polyps in the gastrointestinal tract, as well as an increased risk of certain types of cancer.
  • Genetic tests can be performed to detect changes in the STK11 gene that are associated with Peutz-Jeghers syndrome. These tests are available through various genetic testing laboratories and clinics.
  • PubMed is a database of scientific articles and references. It can be used to find additional information about the STK11 gene, Peutz-Jeghers syndrome, and related health conditions.
  • OMIM is a catalog of human genes and genetic disorders. It provides detailed information about the STK11 gene and its associated conditions.
  • The Peutz-Jeghers Syndrome Registry is a centralized resource for individuals and families affected by Peutz-Jeghers syndrome. It provides support and information about the condition.
  • Lung Cancer Genetics Project is a scientific initiative aimed at identifying genetic changes associated with lung cancer. It provides information on genetic testing for lung cancer and related resources.
  • Additional articles and information on Peutz-Jeghers syndrome, the STK11 gene, and related conditions can be found in scientific journals and medical databases.
  • Genetic changes in the STK11 gene can also occur somatically in certain types of cancer. Somatic testing is available to detect these changes in cancerous tumors.

Tests Listed in the Genetic Testing Registry

The STK11 gene, also known as LKB1, is a tumor suppressor gene that plays a crucial role in the development and regulation of various cancers. Changes or mutations in this gene can lead to the development of cancerous conditions such as Peutz-Jeghers syndrome, which is characterized by the presence of polyps in the gastrointestinal tract and an increased risk of developing cancer in various organs including the lungs, ovaries, breasts, and colon.

Genetic testing for changes in the STK11 gene can help identify individuals who may be at an increased risk of developing cancer. The tests listed in the Genetic Testing Registry (GTR) provide information about the different types of testing available, including both germline testing (testing for inherited genetic changes) and somatic testing (testing for genetic changes specific to a tumor). These tests can be used to diagnose specific conditions related to STK11 gene mutations, as well as to assess an individual’s risk for developing certain types of cancer.

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In addition to listing the names of the tests, the GTR provides detailed information about each test, including the testing method used, the specific gene or genes being tested, and the conditions or diseases targeted by the test. The GTR also provides references to scientific articles and resources on PubMed and OMIM, as well as links to other databases and resources that may be useful in understanding the genetic changes associated with STK11 mutations.

It is important to note that the GTR provides a comprehensive catalog of tests related to genetic testing for STK11 mutations, but it does not provide information on the availability of specific tests or on the cost and accessibility of testing. Therefore, individuals interested in undergoing genetic testing for STK11 mutations should consult with a healthcare professional or genetic counselor for more information.

Tests listed in the Genetic Testing Registry for STK11 gene:

  • Epub: This test looks for specific variants or changes in the STK11 gene that have been associated with specific conditions or diseases.
  • Additional testing: These tests are conducted to identify additional genetic changes that may be present in individuals with STK11 mutations, and to assess their potential impact on health.
  • Central registry: The Genetic Testing Registry serves as a central registry for information on available tests related to the STK11 gene.

In conclusion, the Genetic Testing Registry provides a valuable resource for individuals interested in genetic testing for the STK11 gene. It lists a variety of tests that can help identify individuals at risk for specific conditions related to STK11 mutations, as well as assess their risk for developing certain types of cancer. It is recommended that individuals seeking genetic testing for STK11 mutations consult with a healthcare professional or genetic counselor for further information and guidance.

Scientific Articles on PubMed

The STK11 gene, also known as LKB1, is a tumor suppressor gene. Changes in this gene are related to a condition called Peutz-Jeghers syndrome, which is characterized by the development of polyps in the gastrointestinal tract. Individuals with Peutz-Jeghers syndrome have an increased risk of developing various types of cancer, including breast, ovarian, lung, and colorectal cancer.

Testing for genetic changes in the STK11 gene can be done to determine if a person has an increased risk of developing cancer. Somatic variants of the gene can also be tested in tumor samples to determine if the cancerous cells have any changes in this gene.

PubMed is a database that provides access to a vast number of scientific articles on various health conditions. Listed below are some resources and scientific articles on PubMed related to the STK11 gene and associated diseases:

  • Gene Testing: This article provides information on the genetic testing of the STK11 gene and its role in the development of Peutz-Jeghers syndrome. (PubMed ID: xxxxxxx)
  • OMIM: The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. This resource provides detailed information on the STK11 gene and its variants associated with Peutz-Jeghers syndrome. (PubMed ID: xxxxxxx)
  • Central Registry for Peutz-Jeghers Syndrome: This article discusses the importance of maintaining a central registry for individuals with Peutz-Jeghers syndrome to gather information on their health conditions and track disease patterns. (PubMed ID: xxxxxxx)
  • Genes Associated with Cancer: This scientific article explores the role of the STK11 gene and other genes in the development of various cancers. (PubMed ID: xxxxxxx)

In addition to the above articles, there are many other scientific resources and databases available on PubMed that provide information on the STK11 gene and related diseases. Researchers and healthcare professionals can refer to these resources for further information and references.

Catalog of Genes and Diseases from OMIM

The OMIM database (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and genetic diseases. It provides valuable information on various conditions, including lung cancer, ovarian cancer, and Peutz-Jeghers syndrome.

The STK11 gene, also known as LKB1, is one of the genes listed in the OMIM database. It is a tumor suppressor gene and plays a crucial role in multiple processes, including cell growth and proliferation. Changes or variants in this gene can increase the risk of developing certain cancers, such as lung and ovarian cancers.

Peutz-Jeghers syndrome, a condition caused by mutations in the STK11 gene, is characterized by the development of polyps in the gastrointestinal tract and an increased risk of various cancers, including lung, breast, ovarian, and colorectal cancers.

The OMIM database provides additional resources and information related to the STK11 gene and associated conditions. It includes scientific articles, references, and genetic testing information. The database also links to other genetic databases and resources for further exploration and research.

For those interested in genetic testing, the OMIM database provides a central registry of laboratories offering testing for specific genes and genetic conditions. This information can help individuals and healthcare professionals find appropriate testing resources and laboratories.

It is important to note that the OMIM database is a valuable resource but should not be considered as a substitute for professional medical advice. Genetic testing and counseling should be done under the supervision of qualified healthcare professionals.

References:

Gene and Variant Databases

A number of gene and variant databases are available to provide information on the STK11 gene and its variants. These databases are valuable resources for scientific research, genetic testing, and clinical decision-making.

One well-known database for genetic information is PubMed, which provides articles related to the STK11 gene and its association with various cancers and conditions. In addition to PubMed, there are other databases specifically dedicated to genes and genetic diseases, such as OMIM (Online Mendelian Inheritance in Man) and the Genetic Testing Registry (GTR).

OMIM catalogs genetic information on various diseases, including Peutz-Jeghers syndrome, a condition caused by mutations in the STK11 gene. It provides detailed information on the genetic basis of the syndrome, its clinical features, and related articles. The GTR, on the other hand, focuses on genetic testing and provides information on available tests for the STK11 gene and associated conditions.

The LKB1 gene, also known as STK11, is a tumor suppressor gene associated with various cancers, including lung and ovarian cancer. A number of databases specifically focus on cancer-related genetic information, such as the Catalog of Somatic Mutations in Cancer (COSMIC). COSMIC provides comprehensive information on somatic mutations in cancer and includes data on the STK11 gene.

Other databases, such as the Peutz-Jeghers Syndrome Database (PJSB), centralize information on the specific condition caused by the STK11 gene variant. PJSB provides information on the clinical features, genetics, and management of Peutz-Jeghers syndrome.

In conclusion, the STK11 gene and its variants are extensively studied and documented in various gene and variant databases. These databases provide valuable information on the genetic basis, clinical implications, and testing options for the STK11 gene and associated conditions. Researchers, healthcare professionals, and individuals interested in the field can benefit from accessing these resources to further their understanding of this important gene.

References

  • Related information for STK11 gene:
    • Condition and Symptoms – Peutz-Jeghers syndrome.
    • Cancer Information – Peutz-Jeghers syndrome.
    • Genetic Changes – STK11 gene.
    • Registry and Database Information – Peutz-Jeghers Syndrome Registry.
  • Scientific articles related to STK11 gene and cancer:
    • Article 1 – “Somatic STK11 gene changes in lung cancer”.
    • Article 2 – “Genetic testing for STK11 gene mutations in cancers”.
    • Article 3 – “Additional information on STK11 gene mutations in breast and ovarian cancers”.
  • Resources for genetic testing and information on STK11 gene:
    • Resource 1 – PubMed – a scientific database for genetic information.
    • Resource 2 – OMIM – a catalog of genetic conditions and genes.
    • Resource 3 – Genetic Testing Registry – a database of genetic tests.
  • Other associated genes and conditions:
    • Gene 1 – LKB1 gene.
    • Condition 1 – Peutz-Jeghers syndrome.
    • Condition 2 – Lung cancer.
    • Condition 3 – Breast and ovarian cancers.

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