How long will a person with stage 4 colon cancer live
New cases are also referred to as incident cases in other publications. Rates of new cases are also referred to as incidence rates.
Cancer Stat Facts: Colorectal Cancer
New cases come from SEER 12. Deaths come from U.S. Mortality.
All Races, Both Sexes. Rates are Age-Adjusted.
Modeled trend lines were calculated from the underlying rates using the Joinpoint Trend Analysis Software.
The 2020 incidence rate is displayed but not used in the fit of the trend line(s). Impact of COVID on SEER Cancer Incidence 2020 data
New cases are also referred to as incident cases in other publications. Rates of new cases are also referred to as incidence rates.
View Data Table
Rate of New Cases and Deaths per 100,000: The rate of new cases of colorectal cancer was 36.6 per 100,000 men and women per year. The death rate was 13.1 per 100,000 men and women per year. These rates are age-adjusted and based on 2016–2020 cases and deaths.
Lifetime Risk of Developing Cancer: Approximately 4.1 percent of men and women will be diagnosed with colorectal cancer at some point during their lifetime, based on 2017–2019 data.
Preventable medical errors kill about 22,000 patients a year, according to research from the Yale School of Medicine. That’s much less than a previously reported number of 250,000 deaths a year where medical error is to blame.
Prevalence of This Cancer: In 2020, there were an estimated 1,388,422 people living with colorectal cancer in the United States.
Did you know?
Colorectal cancer is the fourth most common cancer diagnosed in the United States.
Did You Know? Video Series
Survival Statistics
How Many People Survive 5 Years Or More after Being Diagnosed with Colorectal Cancer?
Relative survival is an estimate of the percentage of patients who would be expected to survive the effects of their cancer. It excludes the risk of dying from other causes. Because survival statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. No two patients are entirely alike, and treatment and responses to treatment can vary greatly.
65.0%
Based on data from SEER 22 (Excluding IL/MA) 2013–2019. Gray figures represent those who have died from colorectal cancer. Green figures represent those who have survived 5 years or more.
- More about survival statistics
- Additional colorectal cancer survival statistics in SEER*Explorer
Survival by Stage
Cancer stage at diagnosis, which refers to extent of a cancer in the body, determines treatment options and has a strong influence on the length of survival. In general, if the cancer is found only in the part of the body where it started it is localized (sometimes referred to as stage 1). If it has spread to a different part of the body, the stage is regional or distant. The earlier colorectal cancer is caught, the better chance a person has of surviving five years after being diagnosed. For colorectal cancer, 35.5% are diagnosed at the local stage. The 5-year relative survival for localized colorectal cancer is 90.9%.
Percent of Cases & 5-Year Relative Survival by Stage at Diagnosis: Colorectal Cancer
| Stage | Percent of Cases | 5-Year Relative Survival |
|---|---|---|
| Localized Confined to Primary Site |
35% | 90.9% |
| Regional Spread to Regional Lymph Nodes |
36% | 73.4% |
| Distant Cancer Has Metastasized |
23% | 15.6% |
| Unknown Unstaged |
6% | 48.6% |
Percent of Cases by Stage
- Localized (35%)
Confined to Primary Site - Regional (36%)
Spread to Regional Lymph Nodes - Distant (23%)
Cancer Has Metastasized - Unknown (6%)
Unstaged
5-Year Relative Survival
SEER 22 (Excluding IL/MA) 2013–2019, All Races, Both Sexes by SEER Combined Summary Stage
- More about colorectal cancer staging
- Additional statistics on colorectal cancer by stage in SEER*Explorer
New Cases and Deaths
How Common Is This Cancer?
Compared to other cancers, colorectal cancer is fairly common.
| Rank | Common Types of Cancer | Estimated New Cases 2023 |
Estimated Deaths 2023 |
|---|---|---|---|
| 1. | Breast Cancer (Female) | 297,790 | 43,170 |
| 2. | Prostate Cancer | 288,300 | 34,700 |
| 3. | Lung and Bronchus Cancer | 238,340 | 127,070 |
| 4. | Colorectal Cancer | 153,020 | 52,550 |
| 5. | Melanoma of the Skin | 97,610 | 7,990 |
| 6. | Bladder Cancer | 82,290 | 16,710 |
| 7. | Kidney and Renal Pelvis Cancer | 81,800 | 14,890 |
| 8. | Non-Hodgkin Lymphoma | 80,550 | 20,180 |
| 9. | Uterine Cancer | 66,200 | 13,030 |
| 10. | Pancreatic Cancer | 64,050 | 50,550 |
Colorectal cancer represents 7.8% of all new cancer cases in the U.S.
In 2023, it is estimated that there will be 153,020 new cases of colorectal cancer and an estimated 52,550 people will die of this disease.
Who Gets This Cancer?
Colorectal cancer is more common in men than women and among those of African American descent. The rate of new cases of colorectal cancer was 36.6 per 100,000 men and women per year based on 2016–2020 cases, age-adjusted.
Rate of New Cases per 100,000 Persons by Race/Ethnicity & Sex: Colorectal Cancer
Males
| All Races | 42.1 |
|---|---|
| Hispanic | 39.6 |
| Non-Hispanic American Indian/Alaska Native | 52.3 |
| Non-Hispanic Asian/Pacific Islander | 35.3 |
| Non-Hispanic Black | 50.4 |
| Non-Hispanic White | 42.3 |
Females
| All Races | 32.0 |
|---|---|
| Hispanic | 28.4 |
| Non-Hispanic American Indian/Alaska Native | 45.1 |
| Non-Hispanic Asian/Pacific Islander | 25.0 |
| Non-Hispanic Black | 37.2 |
| Non-Hispanic White | 32.5 |
Non-Hispanic American Indian/
Alaska Native
Non-Hispanic Asian /
Pacific Islander
Non-Hispanic Black
Non-Hispanic White
SEER 22 2016–2020, Age-Adjusted
Percent of New Cases by Age Group: Colorectal Cancer
| Age Range | Percent of New Cases |
|---|---|
| 0.3% | |
| 20–34 | 2.0% |
| 35–44 | 4.9% |
| 45–54 | 15.1% |
| 55–64 | 22.8% |
| 65–74 | 25.5% |
| 75–84 | 19.0% |
| >84 | 10.4% |
Colorectal cancer is most frequently diagnosed among people aged 65–74.
Median Age
At Diagnosis
66
SEER 22 2016–2020, All Races, Both Sexes
Who Dies From This Cancer?
For colorectal cancer, death rates increase with age. Colorectal cancer is the second leading cause of cancer death in the United States. The death rate was 13.1 per 100,000 men and women per year based on 2016–2020 deaths, age-adjusted.
Death Rate per 100,000 Persons by Race/Ethnicity & Sex: Colorectal Cancer
Males
| All Races | 15.7 |
|---|---|
| Hispanic | 13.5 |
| Non-Hispanic American Indian/Alaska Native | 20.8 |
| Non-Hispanic Asian/Pacific Islander | 10.9 |
| Non-Hispanic Black | 22.3 |
| Non-Hispanic White | 15.5 |
Females
| All Races | 11.0 |
|---|---|
| Hispanic | 8.5 |
| Non-Hispanic American Indian/Alaska Native | 14.3 |
| Non-Hispanic Asian/Pacific Islander | 7.7 |
| Non-Hispanic Black | 14.3 |
| Non-Hispanic White | 11.1 |
Non-Hispanic American Indian/
Alaska Native
Non-Hispanic Asian /
Pacific Islander
Non-Hispanic Black
Non-Hispanic White
U.S. 2016–2020, Age-Adjusted
Percent of Deaths by Age Group: Colorectal Cancer
| Age Range | Percent of Deaths |
|---|---|
| 0.0% | |
| 20–34 | 0.7% |
| 35–44 | 2.7% |
| 45–54 | 9.2% |
| 55–64 | 19.4% |
| 65–74 | 24.5% |
| 75–84 | 23.5% |
| >84 | 20.0% |
The percent of colorectal cancer deaths is highest among people aged 65–74.
Median Age
At Death
72
U.S. 2016–2020, All Races, Both Sexes
Trends in Rates
Changes Over Time
Keeping track of new cases, deaths, and survival over time (trends) can help scientists understand whether progress is being made and where additional research is needed to address challenges, such as improving screening or finding better treatments.
Using statistical models for analysis, age-adjusted rates for new colorectal cancer cases have been falling on average 1.8% each year over 2010–2019. Age-adjusted death rates have been falling on average 2.0% each year over 2011–2020. 5-year relative survival trends are shown below.
New Cases, Deaths and 5-Year Relative Survival
New cases come from SEER 8. Deaths come from U.S. Mortality.
All Races, Both Sexes. Rates are Age-Adjusted.
Modeled trend lines were calculated from the underlying rates using the Joinpoint Trend Analysis Software.
The 2020 incidence rate is displayed but not used in the fit of the trend line(s). Impact of COVID on SEER Cancer Incidence 2020 data
SEER 8 5-Year Relative Survival Percent from 1975–2015, All Races, Both Sexes.
Modeled trend lines were calculated from the underlying rates using the Joinpoint Survival Model Software.
View Data Table
Interactive Statistics with SEER*Explorer
SEER*Explorer is an interactive website that provides easy access to a wide range of SEER cancer statistics. It provides detailed statistics for a cancer site by gender, race, calendar year, age, and for a selected number of cancer sites, by stage and histology.
More About This Cancer
Cancer and the Colon and Rectum
Figure: Anatomy of the Lower Digestive System
Click to enlarge.
Figure: Anatomy of the Lower Digestive System
Figure: Gastrointestinal (digestive) system anatomy; shows esophagus, liver, stomach, colon, small intestine, rectum, and anus.
Cancer that begins in the colon is called colon cancer, and cancer that begins in the rectum is called rectal cancer. Cancer that starts in either of these organs may also be called colorectal cancer.
The digestive system is made up of the esophagus, stomach, and the small and large intestines. The first 6 feet of the large intestine are called the large bowel or colon. The last 6 inches are the rectum and the anal canal.
Additional Information
More Information
Here are some resources for learning more about colorectal cancer.
- More about risk factors for colorectal cancer
- More about symptoms and diagnosis of colorectal cancer
- More about treatment options for colorectal cancer
- More about clinical trials
- More about cancer prevention
References
All statistics in this report are based on statistics from SEER and the Centers for Disease Control and Prevention’s National Center for Health Statistics. Most can be found within SEER*Explorer.
Suggested Citation
All material in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.
SEER Cancer Stat Facts: Colorectal Cancer. National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/statfacts/html/colorect.html
These stat facts focus on population statistics that are based on the U.S. population. Because these statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. To see tailored statistics, browse SEER*Explorer. To see statistics for a specific state, go to the State Cancer Profiles.
The statistics presented in these stat facts are based on the most recent data available, most of which can be found in SEER*Explorer. In some cases, different year spans may be used.
Estimates of new cases and deaths for 2023 are projections made by the American Cancer Society (ACS), based on earlier reported data.
Cancer is a complex topic. There is a wide range of information available. These stat facts do not address causes, symptoms, diagnosis, treatment, follow-up care, or decision making, although links are provided to information in many of these areas.
SEER is supported by the Surveillance Research Program (SRP) in NCI’s Division of Cancer Control and Population Sciences (DCCPS). SRP provides national leadership in the science of cancer surveillance as well as analytical tools and methodological expertise in collecting, analyzing, interpreting, and disseminating reliable population-based statistics.
How long will a person with stage 4 colon cancer live?
Stage 4 colon cancer occurs when cancer in the colon spreads or metastasizes to other tissues and organs. The 5-year survival rate for people with stage 4 colon cancer is less than 15%.
The American Cancer Society (ACS) note that the 5-year relative survival rate for people with stage 4 colon cancer that has spread is 14%.
Colon cancer most often spreads to the liver, but it may also reach the lungs, the lymph nodes, or the lining of the abdominal cavity.
However, everyone is different, and other factors contribute to a person’s survival rate.
Share on Pinterest A doctor may recommend multiple tests to accurately diagnose colon cancer.
The correct diagnosis of colon cancer may take patience, as doctors use many tests to detect and locate cancer.
If they identify cancer, they will also use more tests to see whether it has spread.
The tests and processes that can aid a colon cancer diagnosis include:
- a physical examination
- blood tests
- a colonoscopy to look inside the rectum
- a biopsy, in which the doctor takes a sample of tissue and sends it to a laboratory for analysis
- molecular testing to help identify specific characteristics of the tumor that may be important for treatment
- imaging tests, such as CT, PET, ultrasound, or MRI scans, to see whether cancer has spread
- a chest X-ray to check whether cancer has spread to the lungs
After running all of the necessary tests, a doctor will discuss the diagnosis with the individual.
Anyone who receives a stage 4 colon cancer diagnosis will have to make some decisions about the way forward, particularly regarding treatment options.
It is important to discuss all of the options with a doctor and to understand the goal of each treatment.
The treatment options available to people with stage 4 colon cancer are more limited than those suitable for the earlier stages of this cancer. However, there are still some treatment options to consider, as well as other factors to keep in mind.
Surgery
When cancerous cells have spread to distant organs and tissues, surgery is unlikely to cure cancer. There are some cases in which surgery may still be a good option, though.
If a scan reveals that the cancer has only spread to a few small areas, surgery may still be possible. By surgically removing the cancerous cells, doctors hope to help the person live longer.
These surgeries will involve the removal of part of the colon as well as the nearby lymph nodes. Additional surgery may remove the areas of tissue into which the cancer has spread. Doctors will typically also recommend chemotherapy, either before or after the surgery.
If the tumor cells are too large to remove, or there are too many of them, doctors will recommend chemotherapy before the person undergoes any surgical procedures. If this shrinks the tumors, they may then ask a surgeon to proceed with the surgery.
Doctors may also need to perform additional surgical procedures if the cancerous growth is likely to obstruct the colon or is already blocking it. In some cases, minimally invasive surgery, such as placing a stent, may be possible. Surgeons can place a stent, which is a hollow tube that typically consists of mesh metal or plastic, into the colon during a colonoscopy. When successful, a stent may help keep the colon open and make more invasive surgery unnecessary.
Doctors may also recommend a diverting colostomy, which essentially cuts the colon above the cancerous tissue and diverts the waste from the body out through a small opening in the skin.
Chemotherapy
Share on Pinterest Chemotherapy is a primary treatment for advanced cancer.
If the colon cancer has spread too far for surgery to be effective, chemotherapy is the primary treatment option.
Most people with stage 4 colon cancer will receive chemotherapy or specific targeted therapies to help control the cancer progression or symptoms.
Doctors may recommend some treatment regimens that include a targeting drug, which targets either the vascular endothelial growth factor (VEGF) pathway or the epithelial growth factor receptor (EGFR) pathway.
The choice between regimens will vary in each situation. The most suitable option will depend on the types of treatment that a person has had before, their overall health, and their responsiveness to treatment.
It is not uncommon for doctors to try multiple treatments. If the cancer does not respond to the first treatment, they may stop that treatment and start another instead.
Radiation therapy
Doctors may also recommend radiation therapy in late-stage colon cancer to help reduce symptoms such as pain and discomfort. This treatment might even shrink the tumor for a time, but it will not usually cure the cancer.
Hepatic artery infusion
A hepatic artery infusion may be a treatment option for people with colon cancer that has spread to the liver. Hepatic artery infusion is a type of regional chemotherapy, which involves delivering a chemotherapy drug directly into the hepatic artery in the liver. This treatment may help destroy cancer cells without harming the healthy liver cells in the process.
Ablation or embolization
Ablation or embolization may be appropriate for people who have metastatic or reoccurring colorectal cancer that causes a few tumors in the lung or liver that are less than 4 centimeters across.
Ablation uses either radio frequencies, microwaves, or alcohol — which people also call percutaneous ethanol injection (PEI) — to target and kill cancer cells while leaving the surrounding tissues relatively unharmed.
During embolization, a doctor will inject substances into the blood vessels to try to block or reduce the blood flow to cancer cells in the liver.
Palliative care
If cancer progresses to many distant organs and tissues, surgery may not help extend a person’s lifespan. Other treatment options can cause discomfort and may produce additional symptoms that make the person’s quality of life worse.
In these cases, people may decide against medical treatment that seeks to cure the cancer and instead opt for palliative care to try to make living more comfortable.
Palliative care will typically involve finding ways to manage pain and reduce a person’s symptoms so that they can live comfortably for as long as possible.
Share on Pinterest A person’s responsiveness to treatment will depend on a number of factors, such as age and general health.
As the ACS note, colon cancer is the third most commonly diagnosed cancer in both males and females in the United States. One in 22 men and one in 24 women will receive a colon cancer diagnosis during their lifetime.
Stage 4 colon cancer is late-stage cancer in which the disease has spread to other tissues or organs in the body and is, therefore, more difficult to treat. Treatment may only be partially successful, and cancer may be more likely to return after treatment.
The ACS note that the 5-year relative survival rate for stage 4 colon cancer is 14%. However, this does not account for other factors that may affect individual survival rates.
For instance, the success of particular treatment methods may vary among individuals, with treatments that work very well for some people having little effect in others.
Additionally, experts base these statistics on past cases. As treatments tend to get better over time, survival rates may also improve as more effective treatments become available.
Individual factors can also play a significant role in a person’s outcome. For instance, the age and overall health of an individual may affect their responsiveness to treatment.
The rate of cancer progression may change the outlook as well. If the cancer causes complications, such as a blockage in the colon or a hole in the bowel wall, the person’s outlook is likely to change.
This survival statistic also only applies to stage 4 colon cancer when doctors first diagnose it. The survival rate will be different for those in whom the cancer has spread further or returned after treatment.
Stage 4 colon cancer is late-stage cancer. Life expectancy is lower than it is for earlier stages of cancer. The 5-year relative survival rate for stage 4 colon cancer that has spread to other parts of the body is about 14%. However, other factors, such as the chosen treatment methods and the person’s overall health, contribute to life expectancy.
Although there are often still several treatment options available, including surgery and chemotherapy, some people with late-stage cancer choose not to have medical treatment and to seek palliative care instead.
Anyone who receives a diagnosis of stage 4 colon cancer should work closely with their medical team to discuss all the treatment options and decide what will best suit their needs.
Last medically reviewed on May 21, 2019
- Colorectal Cancer
- Cancer / Oncology
How we reviewed this article:
Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
- Colon cancer treatment (PDQ®) — patient version. (2019).
https://www.cancer.gov/types/colorectal/patient/colon-treatment-pdq - Colorectal cancer. (n.d.).
https://www.cancer.org/cancer/colon-rectal-cancer/ - Colorectal cancer facts & figures. (n.d.).
https://www.cancer.org/research/cancer-facts-statistics/colorectal-cancer-facts-figures.html
Colon Cancer Survival Rates by Stage and Types
Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. James Myhre is an American journalist and HIV educator.
Updated on November 11, 2022
Doru Paul, MD, is triple board-certified in medical oncology, hematology, and internal medicine. He is an associate professor of clinical medicine at Weill Cornell Medical College and attending physician in the Department of Hematology and Oncology at the New York Presbyterian Weill Cornell Medical Center.
Colon cancer affects roughly 150,000 Americans each year, resulting in around 53,000 deaths, according to data from the National Cancer Institute. It is today the fourth leading cause of cancer in the United States and the third leading cause of cancer-related deaths.
With advances in diagnosis and treatment, the mortality rate has literally been cut in half since the mid-1980s. Today, 64.6% of people with colon cancer can expect to live for at least five years following their diagnosis; others live for far longer.
FatCamera / E+ / Getty Images
Numerous factors can influence survival times, including the type and stage of cancer as well as certain modifiable and non-modifiable risk factors.
Survival Rate by Stage
Colon cancer, often referred to collectively as colorectal cancer, is a progressive disease that advances in stages if left untreated. To predict the likely outcome (prognosis), doctors will stage the disease based on the characteristics of the tumor and the extent to which it has spread in the body.
For the purpose of estimating survival times, the disease is classified in three stages:
- Localized: Confined to the primary (original) tumor
- Regional: Cancer that has spread to lymph nodes
- Distant: Cancer that has spread to distant organs (also known as metastasis)
Based on data collected by the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program, researchers are able to estimate the percentage of people who will survive for a specific period of time following their diagnosis. This is referred to as the relative survival rate.
Typically, survival rates are described in five-year increments, known as the five-year survival rates. This is the proportion of people who will live for at least five years.
SEER survival estimates are based on all people with a particular type of cancer, irrespective of age, general health, cancer grade, or cancer cell type.
According to SEER estimates for 2020, the five-year survival rate for colorectal cancer in the United States breaks down as follows:
| SEER Stage | Percentage Diagnosed | Five-Year Survival Rate |
|---|---|---|
| Localized | 38% | 90.2% |
| Regional | 35% | 71.8% |
| Distant | 22% | 14.3% |
| Unstaged | 4% | 37.5% |
| Overall | 100% | 64.6% |
Survival Rate by Cancer Type
The majority of colon cancers involve a type of cancer known as adenocarcinoma, which originates in glands and glandular tissues. There are other less common types, some of which are more aggressive and harder to treat.
Adenocarcinoma
Adenocarcinoma accounts for around 95% of all colorectal cancers. Although SEER statistics are based largely on this type of cancer, there are rare subtypes known as mucinous adenocarcinoma and signet-ring cell carcinoma that are far more aggressive.
Mucinous adenocarcinoma originates in mucus-producing glands of the colon. Because the mucus can facilitate the spread of cancer cells, mucinous adenocarcinoma tends to be more invasive. Compared to typical adenocarcinoma, mucinous adenocarcinoma is associated with no less than a 20% reduction in overall survival times.
Signet-ring cell carcinoma accounts for less than 1% of colon cancers and is differentiated by the appearance of its cells. This rare form of adenocarcinoma tends to be extremely aggressive, reflected by an overall five-year survival rate of 36.3%—roughly half of what is expected with typical adenocarcinoma.
Sarcoma
Sarcomas are a broad category of cancers affecting connective tissues. The two types that most commonly affect the colon are gastrointestinal stromal tumors (GIST) and leiomyosarcoma.
GIST originates in a specific type of cell called an interstitial cell and can either be malignant or benign. Of the 30% that are malignant, the majority occur either in the stomach, small intestine, or rectum.
GIST is associated with generally poorer outcomes, with an overall five-year survival rate of 46%.
Leiomyosarcoma is a type of cancer affecting smooth muscles, including those of the colon and rectum. They are extremely rare, accounting for less than 0.1% of all colon cancers, and have an overall five-year survival rate of 43.8%.
Lymphoma
Primary colorectal lymphoma is a type of non-Hodgkin lymphoma (NHL) affecting a type of white blood cell called a lymphocyte. Unlike Hodgkin lymphoma (HL), which typically progresses in an orderly fashion through the lymphatic system, NHL can develop in any part of the body, including the colon.
Primary colorectal lymphomas account for just 0.5% of all colorectal cancers and around 5% of all lymphomas. With that said, they tend to be associated with poorer outcomes, in part because they are difficult to diagnose. Studies suggest that the overall five-year survival rate for primary colorectal lymphoma is 56.4%.
Melanoma
Melanoma is predominately known as a type of skin cancer but can affect any cell that produces the pigment known as melanin. These melanocytes can be found in the gastrointestinal tract and, in rare instances, can lead to primary colorectal melanoma.
Primary colorectal melanoma accounts for around 1% of all colorectal cancers and has by far the worst outcomes, with an overall five-year survival rate of just 20%.
Colon Cancer Doctor Discussion Guide
Get our printable guide for your next doctor’s appointment to help you ask the right questions.
Factors That Influence Survival
The SEER survival estimates only paint a general picture of what to expect if you have colon cancer. Because the estimates are based on everyone with colon cancer, the statistics may not accurately reflect what is ahead for you as an individual.
There are several factors that influence survival times. Some are non-modifiable, meaning that you cannot change them, while others are modifiable and may potentially influence outcomes.
Surgical Resection
The surgical removal of the primary tumor, known as a resection, can increase the odds of remission and reduce the likelihood of disease progression. While surgery remains a primary form of colon cancer treatment, it is not appropriate for everyone.
Some cancers are inoperable and cannot be removed because of their location and/or the general health of the patient. Similarly, advanced metastatic cancers are rarely treated with resection because the procedure is not seen to improve survival times in most people.
When surgery is indicated, the resection of the primary tumor can increase the overall five-year survival rate to 73.8% while reducing the risk of recurrence to just 6.4%.
In people with inoperable colon cancer, a minimally invasive approach called stereotactic radiation therapy (SBRT) offers a viable alternative to surgery. Studies suggest that people who undergo SBRT for stage 4 colorectal cancer have a four-year survival rate of around 43% when accompanied by chemotherapy.
Age
Your age at the time of the colon cancer diagnosis can influence survival times as it can with other diseases. With a median age of diagnosis of 68 in men and 72 in women, older age already plays a central role in the onset of the disease. However, with each subsequent year, the risk of mortality increases.
According to a 2015 study in the Journal of Gastrointestinal Oncology, the overall five-year survival rate for people over 63 was 58.8%, dropping to 40.8% in those over 79—a drop of nearly 30%.
Performance Status
While age clearly plays a role in cancer survival times, not all older people are at equal risk. A person’s performance status (PS)—the ability to take care of oneself and perform everyday activities—also factors in.
PS is measured in several different ways. Chief among them is the Eastern Cooperative Oncology Group (ECOG) system, which classifies PS on a score of 0 (fully active) to 4 (fully disabled). Having a lower score generally means that you are less able to tolerate cancer treatments.
According to a 2017 study from Cleveland Clinic, a low, intermediate, and high PS score translates to a mortality rate of 8.1%, 11.2%, and 32.5%, respectively, within six months of the diagnosis.
The researchers further concluded that PS plays a more central role in survival times than either age or co-occurring medical conditions.
Race
Race plays a central, albeit indirect, role in cancer survival rates due mainly to the lack of access to quality healthcare. This is a narrative that not only affects people with colon cancer but all other health conditions as well.
In the United States, the overall five-year survival rate for Whites with colon cancer is 65.4%. By contrast, Blacks have a five-year survival rate of 54.7%—a reduction of nearly 9%.
Contributing to this statistic is the higher rate of stage 4 colon cancer among Blacks, who are 20% more likely to be diagnosed after the tumor has metastasized compared to Whites.
Weight
Weight plays a role in the onset and progression of colon cancer as it does with many other diseases. Being overweight or obese not only contributes to the risk of the disease but can also influence outcomes after the tumor has been treated. This is especially true in women.
According to a 2013 study in the British Journal of Cancer, women with overweight or obesity have almost twice the risk of dying from colon cancer compared with women of normal weight.
Although the cause of this is poorly understood, having a high body mass index (BMI) increases the risk of insulin resistance, chronic inflammation, and impaired hormone function. Each of these is independently linked to both the onset and progression of colon cancer.
BMI is a dated, flawed measure. It does not take into account factors such as body composition, ethnicity, sex, race, and age.
Even though it is a biased measure, BMI is still widely used in the medical community because it’s an inexpensive and quick way to analyze a person’s potential health status and outcomes.
Routine exercise may improve colon cancer survival, with some studies reporting anywhere from a 40% to 70% reduction in post-treatment mortality compared to people who engage in no exercise.
Smoking
Smoking affects all cancers, and colon cancer is no exception. Cigarette smoke not only induces chronic inflammation but also causes oxidative damage to DNA. These factors not only contribute to the onset of the disease but appear to increase the risk of colon cancer recurrence.
A 2015 review in the Annals of Oncology found that smoking after a colon cancer diagnosis increases the 60-day risk of death by 49% or more compared to never-smokers.
Not surprisingly, smoking cessation was linked to a 78% improvement in survival times compared to people who did not quit.
A Word From Verywell
It can be distressing to be diagnosed with colon cancer and even more distressing to be faced with the survival statistics. Whatever the stage of your cancer, it is important to remember that the statistics are based on everyone with the disease, regardless of their age, health, and other risk factors.
Many people live well beyond their initial prognosis. With newer, improved diagnostics and treatments, those gains are likely to increase. So, rather than focusing on survival times, focus on the factors you can change and keep appraised of the latest treatments and treatment approaches.
By working with your oncologist and become an “expert” on your disease, you are more likely to reap the benefits of treatment by making informed choices.
Frequently Asked Questions
How long can you live with colon cancer?
You can live a long, full life even if you have had colon cancer. In fact, it’s possible that medical treatment can entirely remove the cancer. Some people may have their colon cancer reappear, which is why cancer survivors are recommended to visit their doctor regularly after treatment is finished.
What is signet ring cell carcinoma?
Signet ring cell carcinoma is a type of cancer that causes a tumor to form in the breast, colon, gallbladder, pancreas, stomach, or urinary bladder. However, about 90% of people see it start in the stomach. One study on signet ring cell carcinoma found that it had a much greater survival rate in people who saw it originate in the stomach, compared to those who had it start in other areas of the body, like the pancreas or gallbladder.
21 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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By James Myhre & Dennis Sifris, MD
Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. James Myhre is an American journalist and HIV educator.
