The SLCO1B3 gene is involved in the transport of organic solutes including bilirubin, making it an important gene in various conditions and diseases related to bilirubin metabolism. This gene is also known as solute carrier organic anion transporter family member 1B3 (SLCO1B3) and is listed under different names in various scientific databases and resources.
The SLCO1B3 gene is a member of the SLCO gene family, which plays a crucial role in transporting various substances across cell membranes. The function of SLCO1B3 gene is described in the Online Mendelian Inheritance in Man (OMIM) catalog, a comprehensive resource for genetic diseases. This gene is also listed in other databases such as PubMed, providing additional information and references on the gene’s function and related research.
Mutations or changes in the SLCO1B3 gene can lead to disorders such as Rotor syndrome, a rare genetic condition characterized by elevated levels of bilirubin in the blood. Testing for genetic variants in the SLCO1B3 gene can be performed through specialized genetic tests that provide information on the individual’s risk for certain health conditions related to organic solute transport.
In conclusion, the SLCO1B3 gene plays a crucial role in the transport of organic solutes, particularly bilirubin. Mutations or changes in this gene can lead to various conditions and diseases. Testing for genetic variants in this gene provides important information for assessing an individual’s risk for certain health conditions related to organic solute transport. The SLCO1B3 gene is also listed in various scientific databases and resources, providing a wealth of information and references on its function and related research.
Health Conditions Related to Genetic Changes
The SLCO1B3 gene is responsible for encoding a protein that plays a crucial role in transporting organic compounds across cell membranes. Genetic changes in this gene can lead to various health conditions and disorders.
Scientific testing has identified several genetic changes in the SLCO1B3 gene that are associated with specific health conditions. These changes can affect the function of the gene’s protein, impacting its ability to transport organic compounds effectively.
One such genetic change is the variant known as SLCO1B1. This variant has been extensively studied and is linked to several health conditions and diseases. It has been found to affect the transport of bilirubin, a substance produced by the breakdown of red blood cells, leading to increased levels of bilirubin in the blood. This condition is associated with an increased risk of conditions such as Rotor syndrome.
Information about the SLCO1B3 gene and its related genetic changes can be found in various resources and databases. These include the OMIM registry, which provides detailed information about genes and their associated conditions, as well as PubMed, a database of scientific articles and references.
For individuals who suspect they may have a genetic change in the SLCO1B3 gene, genetic tests are available to confirm the presence of these changes. These tests can be ordered through healthcare providers and specialized laboratories.
It is important to note that genetic changes in the SLCO1B3 gene can be associated with other health conditions not listed here. Additional research is needed to understand the full extent of the gene’s role and its impact on human health.
| Gene | Condition |
|---|---|
| SLCO1B1 | Rotor syndrome |
| SLCO1B1 | Other related conditions |
Rotor syndrome
Rotor syndrome is a genetic condition related to the SLCO1B3 gene. This gene provides instructions for making a protein involved in the transport of organic solutes, including bilirubin, in the blood.
Individuals with Rotor syndrome have a variant of the SLCO1B3 gene that affects the function of the protein, leading to changes in bilirubin levels in the blood. Bilirubin is a substance produced when the body breaks down old red blood cells. In Rotor syndrome, the transport of bilirubin is impaired, resulting in increased levels of bilirubin in the blood.
Rotor syndrome is related to other genes and diseases, and additional information can be found in scientific articles and databases. The SLCO1B1 gene, for example, is closely related to SLCO1B3 and also plays a role in the transport of organic solutes. The Online Mendelian Inheritance in Man (OMIM) catalog provides genetic testing registry and various resources for this information.
Testing for Rotor syndrome and related conditions can be performed using various genetic tests that analyze the SLCO1B3 and related genes. These tests can help diagnose the condition and provide additional information on the specific variant of the gene. Pubmed is a good resource for finding scientific articles related to Rotor syndrome, SLCO1B3, and other related genes and conditions.
For more information and references, please refer to the following resources:
- OMIM (Online Mendelian Inheritance in Man) catalog
- Pubmed (scientific articles database)
- Genetic testing registries and databases
Other Names for This Gene
The SLCO1B3 gene is also known by other names in various databases and scientific resources. Some of the other names for this gene include:
- databases
- information
- catalog
- transporting
- blood
- to
- conditions
- transport-
- related
- scientific
- the
- provides
- testing
- variant
- organic
- related
- names
- genes
- resources
- from
- references
- this
- on
- for
- making
- other
- additional
- genes
- tests
- diseases
- polypeptide
- genetic
- this
- bilirubin
- and
- articles
- health
- changes
- in
- syndrome
- function
- pubmed
- gene
- rotor
- solu_listcoe
- listed
- registry
- omim
- tests
Additional Information Resources
For additional information on SLCO1B3 gene function, its role in making and transporting organic solutes in the blood, and its genetic variant and related health conditions, the following resources can be listed:
- OMIM (Online Mendelian Inheritance in Man) provides scientific articles and information on genes, genetic variants, and related diseases. It offers a catalog of testing information and related diseases.
- PubMed is a database of scientific articles and research papers on various topics. Searching for “SLCO1B3 gene” or related keywords can provide additional information on its function and related conditions.
- NIH Genetic Testing Registry lists information on genetic tests, including those related to the SLCO1B3 gene and its variants. It provides information on the purpose of testing and relevant laboratories.
- ROTOR (Rotor syndrome) is a genetic condition related to the SLCO1B1 gene. Additional information on this syndrome and its connection to SLCO1B3 can be found in articles and resources specific to ROTOR syndrome.
These resources offer a wealth of information on SLCO1B3 gene function, its genetic variants, and related health conditions. They can be valuable references for scientific research, genetic testing, and understanding the role of genes in various diseases.
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry (GTR) provides a catalog of tests for genetic conditions, including those related to the SLCO1B3 gene. This gene is responsible for transporting bilirubin, a substance found in the blood, as well as other organic molecules.
Tests listed in the GTR include those that identify variants in the SLCO1B3 gene and assess their impact on the gene’s function. These tests can help diagnose or predict certain conditions, such as Rotor syndrome, that are related to changes in the SLCO1B3 gene.
Additional tests listed in the GTR may focus on other genes involved in the transport of bilirubin or other substances. These tests can provide important information for the diagnosis and management of various health conditions.
The GTR also provides references to scientific articles and databases, such as PubMed and OMIM, which contain further information on the SLCO1B3 gene and related tests.
By making these resources available, the GTR serves as a valuable tool for healthcare professionals and individuals seeking information on genetic testing for a range of conditions.
Tests Listed in the Genetic Testing Registry:
- SLCO1B3 gene variant testing
- Tests for Rotor syndrome
- Tests for other genes involved in bilirubin transport
- Additional tests for related conditions and genes
References:
- Genetic Testing Registry: information on genetic tests for various conditions
- PubMed: scientific articles providing further information on the SLCO1B3 gene and related tests
- OMIM: a database with genetic information on various diseases and genes
Scientific Articles on PubMed
PubMed is a catalog of scientific articles that provides a wealth of information on various topics related to health and diseases. In the context of the SLCO1B3 gene, PubMed lists a number of articles related to the function and role of this gene in transporting solute and organic compounds.
One of the main focuses of the articles is the role of SLCO1B3 gene in transporting bilirubin, a substance involved in the metabolism of red blood cells. Various studies have explored the genetic variants of SLCO1B3 and their impact on bilirubin transport and related conditions, such as Dubin-Johnson syndrome.
Additionally, PubMed provides references to articles on testing methods and genetic tests related to SLCO1B3 and other genes involved in organic compound transport. The articles also discuss the use of SLCO1B3 testing in the diagnosis and management of various diseases and conditions.
In making use of SLCO1B3 genetic testing, PubMed lists resources and databases such as OMIM and the Genetic Testing Registry that provide additional information on this gene and related conditions.
Overall, PubMed offers a comprehensive collection of scientific articles on the SLCO1B3 gene, its function in organic compound transport, and its relevance to various diseases and conditions.
Catalog of Genes and Diseases from OMIM
The Catalog of Genes and Diseases from OMIM provides a comprehensive list of genes and diseases related to the SLCO1B3 gene. This gene is responsible for transporting solute organic compounds, such as bilirubin, in the blood.
The catalog includes articles, databases, and other scientific resources that provide information on the function of the SLCO1B3 gene and its role in genetic conditions and diseases. It also lists related genes and genetic changes that are associated with this gene.
In addition, the catalog provides references to additional resources, such as PubMed, for further reading and research on the SLCO1B3 gene and related health conditions. It also includes information on tests and testing resources, including the OMIM registry, for detecting variants in this gene.
One of the diseases associated with the SLCO1B3 gene is Rotor syndrome, which is characterized by elevated levels of bilirubin in the blood. The catalog provides related names and information on this syndrome, making it a valuable resource for clinicians and researchers.
Overall, the Catalog of Genes and Diseases from OMIM provides a comprehensive and up-to-date collection of information on the SLCO1B3 gene and its related diseases and conditions. It serves as a valuable reference for researchers, clinicians, and individuals interested in understanding the genetic basis of various health conditions.
Gene and Variant Databases
The SLCO1B3 gene, also known as solute carrier organic anion transporter family member 1B3, provides instructions for making a protein that is involved in transporting bilirubin, a substance produced from the breakdown of red blood cells, from the blood into the liver. Variants in this gene can affect the function of the protein, leading to changes in bilirubin transport.
There are various gene and variant databases that provide scientific references, information, and resources related to SLCO1B3 and its associated variants. These databases include:
- OMIM: The Online Mendelian Inheritance in Man (OMIM) catalog provides information on genes, genetic conditions, and diseases.
- PubMed: PubMed is a database of scientific articles and publications, providing access to research papers on SLCO1B3 and its variants.
- Other Gene Databases: In addition to OMIM and PubMed, there are other gene databases that catalog information on SLCO1B3 and related genes.
- Variant Databases: Variant databases specifically focus on genetic changes and variants in genes, including SLCO1B3.
- Health Testing Registries: Some registries and databases provide testing resources and information on conditions related to SLCO1B3 variants.
- Additional Resources: There are additional resources available, such as articles, related to SLCO1B3 and its variants for further information.
These databases and resources can be valuable for researchers, healthcare professionals, and individuals seeking information on SLCO1B3 variants and their associations with health conditions.
Disclaimer: The information provided above is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional for diagnostic testing and treatment options.
References
- Registry of Genomic Variant – A database that lists changes in DNA sequence that are associated with genetic conditions: https://databases.lovd.nl/shared/genes/SLCO1B3
- OMIM – Online Mendelian Inheritance in Man, a catalog of human genes and genetic disorders: https://omim.org/
- PubMed – A database of scientific articles, providing additional information on the function and related genes of SLCO1B3: https://pubmed.ncbi.nlm.nih.gov/
- Health Genetic Testing – A resource that provides information and tests for genetic conditions related to SLCO1B3 gene: https://www.healthgenetictesting.com/
- Bilirubin Transporter Polypeptide – An article discussing the function and transporting ability of the SLCO1B3 gene: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283471/
- GeneTests – A resource that offers information about genetic testing options for SLCO1B3 gene related diseases: https://www.genetests.org/
- Rotterdam Open Variation Database – A database that collects information about genetic changes in the SLCO1B3 gene: https://databases.lovd.nl/shared/variants/SLCO1B3