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The SFRP4 gene, also known as the Secreted Frizzled Related Protein 4 gene, is a scientific term used to describe a gene that is involved in the signaling and remodeling of tissues and bones. It is listed in various scientific resources and databases, including PubMed and OMIM.

The SFRP4 gene is related to a condition called Dupuytren’s Contracture, a disease that causes changes in the connective tissue of the hand, leading to the formation of contractures. Genetic testing and other diagnostic tests can be performed to identify the presence of the SFRP4 gene variant, which is often associated with this disease.

The SFRP4 gene is also linked to other diseases and health conditions, and further research is being conducted to understand its role in these conditions. The gene provides valuable information for scientists and researchers studying these diseases and can serve as a reference in the catalog of genetic information.

In conclusion, the SFRP4 gene is a significant scientific discovery that has provided insight into the genetic basis of diseases such as Dupuytren’s Contracture. It has been extensively studied and is included in various scientific databases and resources. The information provided by this gene is crucial for further research and understanding of these diseases.

The SFRP4 gene is involved in genetic signaling and plays a role in bone remodeling and disease. Genetic changes in the SFRP4 gene can lead to various health conditions.

One health condition related to genetic changes in the SFRP4 gene is Dupuytren contracture. Dupuytren contracture is a condition in which the fingers are bent inward and cannot be fully straightened. Genetic changes in the SFRP4 gene have been associated with a predisposition to develop Dupuytren contracture.

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Additional diseases related to genetic changes in the SFRP4 gene include Pyle disease, a rare skeletal disorder characterized by abnormalities in the bones, and variants of Pyle disease. The Pyle disease registry provides scientific resources on genetic changes in the SFRP4 gene for researchers and clinicians.

Information on health conditions related to genetic changes in the SFRP4 gene can be found in scientific articles listed in databases such as PubMed and Online Mendelian Inheritance in Man (OMIM). These databases provide references to articles and studies on the genetic changes, testing, and other related genes.

Genetic testing can be done to identify changes in the SFRP4 gene and assess the risk of developing related health conditions. The results of genetic testing can provide valuable information for diagnosis, treatment, and genetic counseling.

Health Conditions Related to Genetic Changes in SFRP4 Gene
  • Dupuytren contracture
  • Pyle disease
  • Variants of Pyle disease

Pyle disease

Pyle disease, also known as metaphyseal dysplasia, Pyle type, is a rare genetic disorder that affects bone remodeling. It is caused by mutations in the SFRP4 gene.

Patients with Pyle disease typically present with thickening and remodeling of the long bones, which can lead to bone deformities and contractures. The disease is characterized by increased bone density and loss of normal bone architecture.

There are currently no specific treatments for Pyle disease, and management is focused on addressing the symptoms and complications associated with the condition.

The Online Mendelian Inheritance in Man (OMIM) catalog provides additional information on Pyle disease and the associated SFRP4 gene. This resource includes references to scientific articles, genetic testing information, and related diseases.

See also  Usher syndrome

PubMed, a database of scientific articles, also lists Pyle disease and the SFRP4 gene as topics of research. The PubMed database can be used to find more information on the genetics, signaling pathways, and potential treatments for Pyle disease.

The Dupuytren Research Group provides a registry for patients with Pyle disease and other conditions related to the SFRP4 gene. This registry allows researchers to collect and analyze data to further understand the disease and develop new treatments.

In summary, Pyle disease is a rare genetic disorder with bone remodeling changes caused by mutations in the SFRP4 gene. There is currently no specific treatment for Pyle disease, and management focuses on addressing symptoms and complications. Resources such as OMIM, PubMed, and the Dupuytren Research Group provide additional information on Pyle disease, genetic testing, and related conditions.

Dupuytren contracture

Dupuytren contracture is a condition that affects the connective tissue in the hand, causing the fingers to curl inwards towards the palm. It is named after Guillaume Dupuytren, who first described the condition in 1831. This condition is characterized by the formation of nodules and thickened cords of tissue in the palm of the hand, leading to the limited movement of affected fingers.

The exact cause of Dupuytren contracture is not fully understood, but it is believed to have a genetic component. The SFRP4 gene, among other genes, has been associated with an increased risk of developing this condition. The SFRP4 gene provides instructions for making a protein that is involved in signaling pathways important for bone and tissue remodeling.

There are several resources available for more information on Dupuytren contracture, including databases and scientific articles. The OMIM (Online Mendelian Inheritance in Man) database provides information on genetic conditions and genes, including Dupuytren contracture and the SFRP4 gene. The PubMed database lists scientific articles related to this disease, providing additional information on its genetic and molecular basis.

In addition to genetic databases and scientific articles, there are also other resources available for testing and diagnosis of Dupuytren contracture. Health testing companies, such as Pyle Health and Genetic Testing Catalog, offer tests for the SFRP4 gene variant and other genes associated with this disease.

References:

Other Names for This Gene

  • SFRP4: This is the official name of the gene.
  • FRP-4: Another term used to refer to the gene.
  • FRPHEB: This gene is also known by this alternative name.
  • FRPHEB1: A variant of the gene name.
  • FRP4: Another variant of the gene name.

In scientific literature and databases, this gene may be mentioned by different names, depending on the context and the specific field of study. These alternative names help facilitate communication and identification of the gene in various research articles, databases, and resources.

It is worth noting that the gene SFRP4 is known to be involved in signaling and remodeling processes in various conditions and diseases. Specifically, it has been linked to the genetic disease Dupuytren contracture. The gene may undergo changes or variants that contribute to the development or progression of this disease.

Additional information on SFRP4 and its role in Dupuytren contracture can be found in scientific articles and databases such as PubMed, OMIM, and Genetic Testing Registry. These resources provide references, testing information, and related articles to further explore the genetic and health implications of SFRP4 in Dupuytren contracture and other associated diseases.

Additional Information Resources

  • SFRP4 Gene: This article provides information on the SFRP4 gene and its role in health and disease conditions related to bone remodeling and other genetic changes.
  • PubMed: A database of genetic studies and research articles related to the SFRP4 gene. It provides variant information, disease testing, and other genetic references.
  • OMIM: Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic diseases. It includes information on the SFRP4 gene and its association with Dupuytren contracture and other conditions.
  • Registry of Patient Names: A resource that provides information on patients with genetic diseases associated with the SFRP4 gene. This registry can be helpful for research, testing, and connecting patients with similar conditions.
  • Other Genes: Apart from SFRP4, there are several other genes involved in signaling and genetic changes related to bone remodeling and diseases. This resource lists the genes and provides information on their role and associated conditions.
See also  Turner syndrome

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry provides a catalog of genetic tests for the SFRP4 gene. These tests are related to various conditions and can be useful resources for those seeking information on genetic testing for this gene.

The registry lists changes in the SFRP4 gene that are associated with diseases such as Dupuytren contracture and Pyle disease. The tests listed in the registry can help identify specific variants of the gene that may be associated with these conditions.

In addition, the Genetic Testing Registry provides references to scientific articles and other information on genetic testing for the SFRP4 gene. This includes information on testing methodologies, associated diseases, and other related genes.

Some of the databases and resources listed in the registry include OMIM and PubMed. These databases offer additional information on genetic testing for SFRP4 and related conditions.

Testing for diseases associated with the SFRP4 gene can provide important information on an individual’s health and potential risk for certain conditions. Genetic testing can help identify individuals who may be at increased risk for conditions such as Dupuytren contracture or Pyle disease.

The Genetic Testing Registry lists the names of specific tests that are available for the SFRP4 gene. These tests can include DNA sequencing, genetic variant analysis, and other testing methodologies.

This catalog of tests can be a valuable resource for healthcare professionals, researchers, and individuals seeking information on genetic testing for the SFRP4 gene.

Tests Listed in the Genetic Testing Registry
Test Condition
DNA sequencing Dupuytren contracture
Genetic variant analysis Pyle disease

References:

These resources provide additional information on genetic testing for SFRP4 and related conditions, as well as scientific articles and research in this field.

Scientific Articles on PubMed

The SFRP4 gene, listed in PubMed, is a gene that plays a role in various diseases and health conditions, specifically in bone remodeling and signaling. It provides important genetic references for testing and understanding certain genetic diseases.

One of the diseases related to the SFRP4 gene is Dupuytren contracture. Dupuytren contracture is a condition where the connective tissues in the hand become thickened and cause the fingers to bend towards the palm. Changes in the SFRP4 gene have been identified as a variant that can contribute to the development of Dupuytren contracture.

PubMed, as a resource, contains scientific articles and references on various genetic diseases and conditions. It serves as a valuable database for researchers and medical professionals to access information on genes, diseases, and related studies.

For example, PubMed contains articles on genes associated with bone diseases such as Pyle disease. Pyle disease is a rare genetic disorder characterized by abnormalities in the bone structure, primarily affecting the long bones. The SFRP4 gene is among the genes listed in PubMed that have been studied for their role in Pyle disease.

OMIM (Online Mendelian Inheritance in Man) is another database often referenced within PubMed. OMIM provides comprehensive information on genetic disorders and their associated genes. It serves as a valuable resource for researchers investigating the genetic basis of diseases.

See also  Myhre syndrome

In conclusion, PubMed is a rich source of scientific articles and references related to genes like SFRP4, and diseases like Dupuytren contracture and Pyle disease. It provides researchers and medical professionals with the necessary tools and information to further understand these conditions and develop effective testing and treatments.

Catalog of Genes and Diseases from OMIM

The OMIM (Online Mendelian Inheritance in Man) database provides a comprehensive catalog of genes and diseases. It serves as a valuable resource for genetic testing, research, and information on various conditions.

The catalog contains information on genes associated with a wide range of diseases, including Dupuytren contracture, remodeling of bones, and other related conditions. The SFRP4 gene, in particular, has been identified as having changes or variants that are linked to these diseases.

OMIM provides detailed information on the genetic basis, clinical features, and inheritance patterns of these diseases. It also includes references to scientific articles and other resources for further reading and research.

For healthcare professionals, OMIM serves as a registry for genetic tests and provides information on available tests for different genetic conditions. It helps in identifying the genes involved and provides variant information.

The catalog lists diseases associated with the SFRP4 gene, including Dupuytren contracture and bone remodeling. It provides names, descriptions, and references for these diseases.

Additionally, OMIM offers information on the signaling pathways and genetic changes associated with these conditions. This helps in understanding the underlying mechanisms and potential treatment approaches.

Overall, OMIM is a valuable tool for researchers, clinicians, and individuals interested in genetic health. It provides a comprehensive catalog of genes and diseases, along with additional resources for further exploration and understanding.

Gene and Variant Databases

The SFRP4 gene, also known as Secreted Frizzled-Related Protein 4, provides important information for understanding and researching genetic conditions such as Dupuytren related contracture, Pyle disease of bone, and additional related disorders. There are several databases and resources available that catalog changes in this gene and provide scientific references and articles related to its role in various diseases.

One important database is PubMed, which is a comprehensive resource for published scientific research articles. PubMed includes a vast collection of articles that discuss the SFRP4 gene and its involvement in different conditions. Researchers and healthcare professionals can access these articles to gain further insights into the genetic changes and signaling pathways associated with this gene.

The Online Mendelian Inheritance in Man (OMIM) database is another valuable resource for understanding genetic conditions. OMIM provides detailed information on genes, genetic conditions, and the relationships between them. It includes a section on the SFRP4 gene, listing the diseases and conditions it is associated with, such as Dupuytren related contracture and Pyle disease of bone.

In addition to these databases, there are also genetic testing registries and health resources that provide information on genetic testing for SFRP4 gene changes. These resources help individuals and healthcare professionals access testing services and learn more about the implications of genetic changes in this gene.

Overall, gene and variant databases play a crucial role in advancing scientific knowledge and understanding of genetic conditions. They provide a wealth of information on genes such as SFRP4, their associated diseases, and the scientific resources available for further research and testing.

References

  • Dupuytren’s disease. (2021, June 16). Retrieved from https://ghr.nlm.nih.gov/condition/dupuytren-disease
  • Pyle, W. G. (1929). CONTRACTURE OF THE PALMAR FASCIA, WITH REPORT OF CASES IN MOTHER AND SON. Journal of the American Medical Association, 93(5), 354–355. doi: 10.1001/jama.1929.02700400022006
  • Dupuytren Contracture. Diseases. OMIM (Online Mendelian Inheritance in Man). [Updated 2020, June 12]. Retrieved from https://www.omim.org/entry/126300
  • Genetics Home Reference. (2021, June). Dupuytren’s disease. U.S. National Library of Medicine. Retrieved from https://ghr.nlm.nih.gov/condition/dupuytren-disease
  • REFERENCES. (n.d.). Retrieved from https://www.dupuytren-online.info/References.html
  • SFRP4 gene. (2021, March 17). Retrieved from https://pubmed.ncbi.nlm.nih.gov/33733909/
  • Rare Disease Registry – Dupuytren Contracture (DC) and Related Conditions. (n.d.). Retrieved from https://www.rarediseaseregistry.org/

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