The RARA gene, also known as the retinoic acid receptor alpha gene, is a genetic alpha catalog gene that has been extensively studied and documented. It is listed in various scientific databases, such as PubMed and OMIM, and has been the subject of numerous articles and research studies.
The RARA gene plays a crucial role in the health and differentiation of cells, particularly in the bone marrow. Mutations or translocations involving the RARA gene can lead to diseases such as acute promyelocytic leukemia, a subtype of leukemia characterized by the fusion of the RARα gene with other genes.
Testing for changes in the RARA gene is important for the diagnosis and management of conditions related to this gene. Genetic tests can detect mutations or translocations in the RARA gene, providing valuable information for healthcare professionals and patients. Additionally, genetic testing can help in identifying other genes and proteins that are involved in the differentiation and function of cells.
For additional information on the RARA gene and related conditions, individuals can refer to various resources, including scientific articles, medical references, and genetic databases. These resources provide comprehensive information on the RARA gene, its functions, and its role in diseases.
In conclusion, the RARA gene is an important gene involved in the differentiation and function of cells, particularly in the bone marrow. It is associated with diseases such as acute promyelocytic leukemia and is listed in various scientific databases and resources. Genetic testing for changes in the RARA gene can provide valuable information for healthcare professionals and patients.
Health Conditions Related to Genetic Changes
The RARA gene is associated with several health conditions that are caused by genetic changes. These conditions include:
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- Acute promyelocytic leukemia (APL): A type of leukemia where the RARA gene is involved in a genetic translocation that leads to the fusion of the RARA gene with other genes. This fusion gene disrupts normal cell differentiation and proliferation, leading to the development of APL.
- Variant acute promyelocytic leukemia (APL): In some cases, the RARA gene may have different genetic changes or mutations that contribute to the development of APL. These variants may result in alterations of the RARα protein, which is important for normal cell differentiation and proliferation.
- Other diseases related to genetic changes in RARA: In addition to APL and variant APL, genetic changes in the RARA gene have been implicated in other health conditions, although they are less common. These diseases may affect various cells and tissues, including bone marrow and other organs.
To learn more about the health conditions related to genetic changes in the RARA gene, you can refer to the following scientific resources:
- Scientific articles: PubMed is a valuable resource for finding scientific articles related to the RARA gene and its associated health conditions.
- Genetic databases and registries: Various genetic databases and registries provide information and references on the RARA gene and related health conditions. OMIM (Online Mendelian Inheritance in Man) is one such database that catalogues genetic conditions and provides detailed information.
- Genetic testing: Genetic testing can be performed to identify genetic changes in the RARA gene and help diagnose or assess the risk of developing related health conditions.
By exploring these resources, you can find more information on the genetic changes in the RARA gene and their implications for health.
Acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a type of leukemia characterized by a genetic abnormality involving the RARA gene. The RARA gene, which encodes a receptor for a protein called retinoic acid receptor alpha (RARα), is listed in various genetic databases including PubMed, OMIM, and others.
APL is a cancer of the bone marrow and is caused by a specific genetic translocation involving the RARA gene. This translocation leads to changes in the genetic information, resulting in the production of a fusion protein called promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα).
The PML-RARα protein interferes with normal cell differentiation and proliferation, leading to the development of APL. This fusion protein is specific to APL and is not found in other forms of acute leukemia.
Diagnosis of APL usually involves genetic testing to detect the presence of the PML-RARα fusion gene. Other tests, such as bone marrow aspiration and biopsy, may also be performed to confirm the diagnosis and determine the extent of the disease.
Treatment for APL often involves a combination of chemotherapy and all-trans retinoic acid (ATRA), a form of vitamin A that helps promote cell differentiation. Additional targeted therapies, such as arsenic trioxide, may also be used in certain cases.
For more information on APL and related genetic disorders, the RARA gene, and other proteins involved in APL, the scientific community can refer to resources such as the OMIM database, PubMed articles, and other scientific literature.
References and further reading:
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Other Names for This Gene
This gene is also known by other names:
- alpha retinoic acid receptor alpha (RARA)
- retinoic acid receptor alpha
- Nuclear receptor subfamily 1 group B member 1
- retinoic acid receptor, alpha, isoform 1
It can be found in different sources and databases with various names due to its involvement in a range of biological processes and diseases.
For example, in the OMIM database, it is listed as “retinoic acid receptor, alpha” (OMIM:180240), while in PubMed, it can be found under the name “retinoic acid receptor alpha” with many scientific articles and references related to its role in leukemia and other diseases.
The RARA gene is also associated with the t(15;17) translocation that leads to the formation of a fusion gene with the promyelocytic leukemia (PML) gene. This fusion gene, known as PML-RARA, is found in patients with acute promyelocytic leukemia (APL).
Furthermore, genetic testing using the RARA gene plays a crucial role in diagnosing and monitoring the response to treatment for APL, as well as other conditions related to genetic differentiation, proliferation, and the development of various cells in the bone marrow and other tissues.
Additional information and resources on the RARA gene can be found in genetic testing registries, health-related catalogs, and databases.
| Database | Description |
|---|---|
| OMIM | Online Mendelian Inheritance in Man – a comprehensive catalog of human genes and genetic disorders |
| PubMed | A database of scientific articles and references |
These resources provide valuable information on the RARA gene and its involvement in various genetic conditions and diseases.
Additional Information Resources
Here are some additional resources to learn more about the RARA gene:
- PubMed: A scientific database that provides access to articles on a wide range of topics, including the RARA gene. You can search for specific keywords like “RARA gene” or “RARα protein” to find relevant articles.
- OMIM: The Online Mendelian Inheritance in Man (OMIM) is a genetic database that provides information on genes, genetic conditions, and related proteins. You can search for the RARA gene or related diseases and find detailed information.
- Genetic Testing Registry: This database provides information on genetic tests for various conditions. You can search for tests related to the RARA gene to find out if there are any available tests for specific conditions.
- Related Genes and Proteins: Apart from the RARA gene, there are several other genes and proteins involved in cell differentiation, proliferation, and various diseases. You can explore these genes and proteins to understand their roles in different conditions.
- Promyelocytic Leukemia: The RARA gene is associated with a subtype of acute promyelocytic leukemia. You can find information on this specific form of leukemia and how changes in the RARA gene can lead to the development of the disease.
These resources can provide you with more information on the RARA gene, its functions, and its role in different health conditions. Make sure to explore the references and articles listed in these databases to delve deeper into the topic.
Tests Listed in the Genetic Testing Registry
- The Genetic Testing Registry (GTR) is a comprehensive catalog of genetic tests provided by different laboratories.
- The GTR includes a list of tests related to the RARA gene, which is also known as rarα.
- These tests are designed to detect changes in the RARA gene that may be associated with various diseases and conditions.
- One of the common conditions associated with RARA gene changes is acute promyelocytic leukemia.
- In addition to rarα, the GTR lists other genes and proteins that are related to the differentiation and proliferation of cells in the bone marrow.
- The GTR provides information on genetic tests that can detect and identify changes in these genes and proteins.
- These tests can help in the diagnosis and management of various diseases and conditions.
The GTR is a valuable resource of genetic testing information for healthcare professionals and researchers. It provides references to scientific articles, PubMed, OMIM, and other databases for additional information on the listed tests and genes.
By using the GTR, healthcare professionals can access up-to-date information on genetic tests and their associated conditions. This information can aid in the identification and treatment of genetic diseases and conditions.
| Test Name | Condition | Genes |
|---|---|---|
| Test A | Acute Promyelocytic Leukemia | RARA, PML |
| Test B | Diffuse Large B-Cell Lymphoma | RARA, MYC, BCL2 |
| Test C | Acute Myeloid Leukemia | RARA, FLT3 |
These are just a few examples of the tests listed in the Genetic Testing Registry. The catalog includes a wide range of tests for various diseases and conditions related to the RARA gene and other genes involved in cell proliferation and differentiation.
Scientific Articles on PubMed
Protein coding gene RARA is associated with the health and differentiation of cells. Mutations in this gene are related to various diseases. Resources such as databases and scientific articles on PubMed provide information on the function and role of RARA gene in different conditions.
- RARα protein: The RARA gene codes for a protein known as RARα, which is a receptor for retinoic acid. This protein plays a crucial role in cell proliferation and differentiation.
- Promyelocytic Leukemia: Mutations in the RARA gene can lead to the development of acute promyelocytic leukemia (APL). This type of leukemia is caused by a genetic translocation involving RARA and other genes.
- RARα variant: A specific variant of the RARA gene, called RARAα, has been identified in certain genetic testing. This variant is associated with changes in the regulation of gene activity and can contribute to the development of certain diseases.
PubMed is a database that provides access to a vast collection of scientific articles on various topics. It includes references to publications that discuss the RARA gene, its function, and its role in different diseases. Using PubMed, researchers can find additional information on this gene, including the latest research and studies.
OMIM (Online Mendelian Inheritance in Man) is another valuable resource that provides information on genetic conditions. This database includes entries for genes, including RARA, and provides detailed descriptions of associated disorders and genetic tests.
By referencing scientific articles on PubMed, researchers and healthcare professionals can stay updated with the latest findings and studies on the RARA gene and its implications in various diseases.
Catalog of Genes and Diseases from OMIM
The Catalog of Genes and Diseases from OMIM is a comprehensive resource for information on genetic conditions and related genes. It provides a database of scientific articles, references, and genetic resources related to various diseases and genes, including the RARA gene.
The RARA gene is involved in the proliferation and differentiation of cells in the bone marrow. Changes or mutations in this gene can lead to the development of various diseases, including acute promyelocytic leukemia.
The OMIM catalog lists the RARA gene, along with other genes involved in leukemia and related conditions. It provides information on the genetic changes and protein variants associated with these genes, as well as additional references and resources for further testing and research.
In the catalog, genes are listed with their official names and aliases, making it easier to navigate and search for specific genes. For example, the RARα protein receptor gene can also be referred to as RARA. This ensures that users can find the relevant information regardless of the gene name used in scientific literature.
The catalog provides a wealth of information on the RARA gene, including articles from PubMed and references from other scientific databases. This allows researchers and healthcare professionals to access a wide range of literature and resources to deepen their understanding of the gene and its role in health and disease.
In addition to the RARA gene, the OMIM catalog also includes information on other genes involved in leukemia and related conditions. This comprehensive database makes it a valuable resource for researchers, clinicians, and individuals interested in genetic diseases.
Overall, the Catalog of Genes and Diseases from OMIM is a valuable tool for accessing information on genetic conditions, genes, and related resources. It provides a central repository of scientific knowledge and references, making it easier for researchers and healthcare professionals to stay updated on the latest discoveries in the field of genetics.
Gene and Variant Databases
Gene and variant databases are invaluable resources for researchers and healthcare professionals studying the RARA gene and its associated variants. These databases provide comprehensive information on diseases and conditions associated with changes in this gene, as well as details on the genetic variants themselves.
One such database is the OMIM (Online Mendelian Inheritance in Man) catalog, which lists genetic variations and diseases related to the RARA gene. OMIM provides references to scientific articles and other resources for further reading and research.
Another important database is PubMed, which allows users to search for articles related to the RARA gene and its variants. This database contains a wealth of information on the genetic, health, and scientific implications of these variants.
Gene and variant databases also provide information on the proteins encoded by the RARA gene and their functions. For example, the RARA gene encodes for the RARα (retinoic acid receptor alpha) protein, which plays a crucial role in cell differentiation and proliferation.
In addition to the RARA gene, these databases also catalog information on other genes and variants that may be associated with conditions such as acute promyelocytic leukemia. This allows researchers and clinicians to explore the broader genetic landscape of these diseases and develop more targeted diagnostic tests and treatments.
Overall, gene and variant databases serve as crucial resources for studying the RARA gene and its variants. They provide a wealth of information on diseases, genetic changes, and associated proteins, allowing researchers and healthcare professionals to make informed decisions and advancements in the field.
References
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PubMed: The premier medical database that provides access to a large collection of articles related to the RARA gene, its variants, and diseases associated with it. Available at https://www.ncbi.nlm.nih.gov/pubmed.
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OMIM: Online Mendelian Inheritance in Man is a comprehensive database that provides information on genetic diseases and genes. The RARA gene and related diseases can be found in OMIM. Available at https://www.omim.org.
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Genetic Testing Registry: This database provides information about genetic tests and their associated laboratories. It includes tests for the RARA gene and related conditions. Available at https://www.ncbi.nlm.nih.gov/gtr.
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RARA Gene Catalog: A catalog of information about the RARA gene, including protein structure and variants. Available at https://www.genecards.org/cgi-bin/carddisp.pl?gene=RARA.
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Protein data from UniProt: UniProt is a comprehensive protein database providing information about protein sequence, function, and structure. Information about the RARA gene and its protein can be found here. Available at https://www.uniprot.org.