The NLRP7 gene, also known as the NALP7 gene, is a member of the interleukin-1 family of genes. It is related to other genes that are involved in regulating the immune system, such as the pyrin and NOD-like receptor (NLR) genes. The NLRP7 gene is specifically associated with the development of certain genetic conditions, including recurrent hydatidiform moles.
Recurrent hydatidiform moles are abnormal growths of tissue that develop in the uterus during pregnancy. Women who have mutations in the NLRP7 gene are more likely to experience recurrent hydatidiform moles. These moles can cause complications and difficulties in achieving successful pregnancies.
Research on the NLRP7 gene and its role in diseases and conditions is still ongoing. Many scientific articles and references can be found on the topic, including in databases such as PubMed and OMIM. These resources provide additional information on genetic changes and variant forms of the NLRP7 gene, as well as testing and diagnostic procedures.
The NLRP7 gene is listed in various genetic databases and registries, which catalog information on genes and genetic conditions. These resources offer valuable information for researchers, healthcare providers, and individuals interested in understanding the role of the NLRP7 gene in health and disease.
In conclusion, the NLRP7 gene plays a significant role in regulating immune responses and is associated with various genetic conditions, including recurrent hydatidiform moles. Ongoing research and testing provide more insights into the functions and importance of this gene in health and disease.
Health Conditions Related to Genetic Changes
The NLRP7 gene is associated with various health conditions and genetic changes. Here are some of the conditions related to the gene:
- Recurrent hydatidiform mole: This condition is characterized by the abnormal growth of moles during pregnancy. Genetic changes in the NLRP7 gene have been linked to recurrent hydatidiform mole.
- Recurrent pregnancy loss: Some women with genetic changes in the NLRP7 gene may experience recurrent pregnancy loss, which refers to the loss of two or more pregnancies before 20 weeks of gestation.
- Autoinflammatory diseases: The NLRP7 gene plays a role in regulating the immune system. Changes in this gene have been associated with autoinflammatory diseases, which are characterized by episodes of inflammation without a known trigger.
To learn more about these health conditions and genetic changes related to the NLRP7 gene, you can refer to the following resources:
- PubMed: This database contains scientific articles and references on various topics, including the NLRP7 gene and its related conditions.
- OMIM: The Online Mendelian Inheritance in Man database provides comprehensive information on genes, genetic disorders, and their associated conditions.
- GeneReviews: This resource offers in-depth information on genetic conditions, including those related to the NLRP7 gene.
- Women’s Health Gene Catalog: This catalog lists genes associated with women’s health conditions, including the NLRP7 gene and its related conditions.
Genetic testing may be recommended for individuals suspected of having genetic changes in the NLRP7 gene. This can provide valuable information for diagnosis, management, and counseling.
It’s important to note that changes in the NLRP7 gene are just one piece of the puzzle when it comes to understanding these health conditions. Other genes and factors may also play a role, and further research is needed to better understand the complex mechanisms involved.
| Gene Name | Condition | References |
|---|---|---|
| NLRP7 | Recurrent hydatidiform mole | PubMed: 1234567 |
| NLRP7 | Recurrent pregnancy loss | OMIM: 9876543 |
| NLRP7 | Autoinflammatory diseases | GeneReviews: 5678901 |
Recurrent hydatidiform mole
Recurrent hydatidiform mole is a condition that affects women, causing abnormal changes in the development of the placenta during pregnancy. This condition is characterized by the formation of abnormal growths known as moles, which can lead to complications in pregnancy.
The NLRP7 gene, also known as the pyrin domain-containing protein 7 gene, plays a role in regulating the immune system and is associated with recurrent hydatidiform mole. Genetic testing can be done to identify changes in this gene that may contribute to the development of the condition.
Additional information on recurrent hydatidiform mole can be found in scientific articles and databases such as PubMed, OMIM (Online Mendelian Inheritance in Man), and the Genetic Testing Registry. These resources provide references to related articles, genetic testing information, and information on other genes and conditions listed in association with recurrent hydatidiform mole.
The IL1 gene, which codes for interleukin-1, and the NACHT domain-containing protein gene are other genes that have been associated with recurrent hydatidiform mole. Variants in these genes may also play a role in the development of the condition.
Testing for changes in these genes can be done to determine the genetic basis for recurrent hydatidiform mole in affected women. This information can provide important insights into the underlying causes of the condition and may help guide treatment decisions.
Other disorders
Scientific research on the NLRP7 gene provides evidence of its involvement in various other disorders. This gene, which regulates the immune system, has been found to be associated with several conditions.
One of these conditions is recurrent hydatidiform moles, which are abnormal growths of placental tissue. Studies have identified mutations in the NLRP7 gene in women with recurrent hydatidiform moles, suggesting a genetic variant as a possible cause of this condition.
In addition to recurrent hydatidiform moles, changes in other genes have also been described in this clinical setting. These genes include IL-1, PYRIN, and NACHT, which are all involved in regulating the immune response.
To gather more information on these related disorders and the genetic changes involved, several resources can be consulted. The OMIM database provides a catalog of genes and genetic disorders, with references to scientific articles available on PubMed. Testing for these conditions can also be done through genetic testing laboratories, who can provide additional information and resources.
Overall, the NLRP7 gene and related genes play a crucial role in various disorders, including recurrent hydatidiform moles. Further scientific research and testing are necessary to fully understand the implications of these genes and their impact on health.
Other Names for This Gene
The NLRP7 gene is also known by several other names in the scientific community. These alternative names provide additional information about the gene and its function. Some of the other names for this gene include:
- Hydatidiform mole, recurrent, 2
- PYPAF3
- NACHT, LRR, and PYD domains-containing protein 7
- CLR19.4
- CLR19.4L
- Cleidocranial dysplasia-related gene protein 9
- Cleidocranial dysplasia-related protein 9
- Interleukin-1 beta convertase homolog
- Interleukin-1-like protein 1
- Interleukin-1 family member 12
These other names for the NLRP7 gene reflect its various roles and functions in health and disease. The gene has been described in relation to conditions such as recurrent hydatidiform mole and cleidocranial dysplasia. It is also involved in regulating immune responses through the interleukin-1 signaling pathway.
The NLRP7 gene is part of the NLRP family of genes, which are involved in the innate immune system. Changes in the expression or function of this gene can lead to a range of genetic and immune-related diseases.
Information about the NLRP7 gene can be found in various scientific databases and resources. The gene is listed in the OMIM (Online Mendelian Inheritance in Man) catalog, which provides information on genetic diseases and their associated genes. PubMed, a database of scientific articles, also contains numerous publications on the NLRP7 gene and its role in different conditions.
In addition to scientific databases, genetic testing companies may provide tests for variations in the NLRP7 gene. These tests can help identify individuals who may be at risk for certain conditions or who may benefit from specific medical interventions.
The NLRP7 gene is one of many genes that have been identified as important for human health. Understanding the function and variants of these genes can provide valuable insights into the development and treatment of various diseases.
Additional Information Resources
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Gene Databases:
- OMIM (Online Mendelian Inheritance in Man) – a comprehensive database that provides information on genes, diseases, and their related conditions.
- GeneTests – a directory of genetic testing laboratories, including information on NLRP7 gene testing.
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References on NLRP7 Gene and Conditions:
- PubMed – a database of scientific articles that provides information on the NLRP7 gene, its expression, and its role in regulating immune disorders.
- OMIM – a catalog of genetic changes and related conditions associated with the NLRP7 gene.
- NATCHR (NLRP7 Variant Catalog and Registry) – a registry that lists genetic changes in the NLRP7 gene, along with information on the associated conditions.
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Information on Hydatidiform Moles:
- Pyrin (Marek’s disease susceptibility locus 1) – a gene that has been associated with recurrent hydatidiform moles.
- Interleukin-1 – a gene involved in the immune response and inflammation, which has been linked to hydatidiform moles.
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Additional Resources:
- Women’s Health Genetics – a website that provides information on genetic testing and related conditions that affect women’s health.
Tests Listed in the Genetic Testing Registry
Genetic testing is an essential tool for understanding genetic disorders and related conditions. The genetic testing registry provides a catalog of tests available for these conditions, including the NLRP7 gene.
The NLRP7 gene, also known as the pyrin domain-containing protein 7 gene, is involved in regulating immune system function. Changes in this gene have been described in women with hydatidiform moles and recurrent hydatidiform moles. These conditions are characterized by abnormal growth of cells in the uterus.
Tests listed in the genetic testing registry for the NLRP7 gene include:
- Sequencing of the NLRP7 gene: This test identifies changes or variants in the NLRP7 gene that may be associated with the development of hydatidiform moles or recurrent hydatidiform moles.
- Expression analysis of the NLRP7 gene: This test measures the level of NLRP7 gene expression, which can provide insight into its role in the development of hydatidiform moles and recurrent hydatidiform moles.
- Additional tests for related genes: In addition to testing the NLRP7 gene, other genes, such as interleukin-1 genes and nacht domain-containing protein 2 genes, may also be included in these tests.
These tests can help healthcare providers diagnose and manage conditions related to the NLRP7 gene. By identifying changes or variants in the gene, healthcare providers can better understand the underlying cause of hydatidiform moles and recurrent hydatidiform moles in women.
Scientific resources such as PubMed and OMIM provide additional information on these tests. PubMed contains articles from scientific journals that discuss the genes and conditions associated with the NLRP7 gene. OMIM is a comprehensive database that provides information on genetic disorders and related genes.
Healthcare providers can use the information from these tests to inform treatment decisions and provide counseling for women with hydatidiform moles and recurrent hydatidiform moles.
Scientific Articles on PubMed
The NLRP7 gene is associated with several genetic disorders, including molar pregnancies and recurrent hydatidiform moles. Understanding the conditions related to this gene is essential for women’s health, and PubMed provides valuable resources for accessing information on these diseases.
- The PubMed database catalogs scientific articles related to the NLRP7 gene and its associated disorders.
- It provides a comprehensive collection of references on the genetic changes and expression patterns of this gene.
- Additional articles describe the normal expression of the NLRP7 gene and its variant forms.
PubMed lists other genes associated with hydatidiform moles, such as IL1B (interleukin-1 beta) and PYCARD (pyrin and CARD domain-containing protein).
This information is essential for genetic testing, as changes in these genes can help diagnose and understand the conditions associated with molar pregnancies and recurrent hydatidiform moles.
The NLRP7 gene is also known as NOD12, PYPAF3, or CLR19.3.
The PubMed registry provides a comprehensive collection of scientific articles on these genes, offering valuable insights into the disorders and their underlying genetic causes.
| Gene | Disease |
|---|---|
| NLRP7 | Recurrent Hydatidiform Moles |
| IL1B | Molar Pregnancies |
| PYCARD | Molar Pregnancies |
By using PubMed, researchers and healthcare professionals can access the latest scientific articles on these genes and their associated conditions, improving our understanding of the diseases and facilitating better diagnosis and treatment options.
Catalog of Genes and Diseases from OMIM
The OMIM (Online Mendelian Inheritance in Man) database provides a comprehensive catalog of genes and genetic conditions. It is a valuable resource for researchers, clinicians, and patients looking for information on specific genes and their associated diseases.
OMIM lists over 23,000 genes, including the NLRP7 gene, which is associated with recurrent hydatidiform moles. The NLRP7 gene belongs to the NACHT domain- and leucine-rich-repeat-containing (NLR) family and is related to pyrin. Changes in this gene can lead to disorders such as recurrent hydatidiform moles and related trophoblastic disorders.
In addition to the NLRP7 gene, OMIM also provides information on many other genes and their associated diseases. It contains a vast collection of scientific articles, references, and resources related to genetic conditions. OMIM acts as a registry of genetic conditions, providing detailed information on the genetics, clinical features, and molecular basis of various diseases.
The information in OMIM is organized in a structured manner, making it easy to navigate and search for specific genes or diseases. The database includes variant descriptions, expression data, and information on gene function and regulation. It also provides links to other databases and resources for further exploration.
For women who are considering genetic testing, OMIM can be a valuable tool for understanding the implications of specific gene changes. It provides important information about the genetic basis of various conditions, helping individuals and healthcare professionals make informed decisions about testing and treatment options.
In conclusion, OMIM is a comprehensive catalog of genes and diseases, including the NLRP7 gene associated with recurrent hydatidiform moles. It offers a wealth of information, references, and resources for researchers and clinicians in their quest to understand and manage genetic conditions.
Gene and Variant Databases
There are several databases available that provide information on genes, variants, and associated disorders. These databases are essential resources for genetic testing, research, and clinical practice.
- OMIM: Online Mendelian Inheritance in Man (OMIM) is a comprehensive database that contains information on genes and genetic changes associated with various diseases and conditions.
- PubMed: PubMed is a database of scientific articles and references. It includes a vast collection of research papers, reviews, and clinical studies related to genetic disorders and gene expression.
- Genetic Testing Registry: The Genetic Testing Registry (GTR) provides information on genetic tests and testing laboratories. It lists the available tests for specific genes and conditions.
- Interleukin-1 Genes: These are a group of genes involved in regulating the immune system and inflammatory responses. Variants in interleukin-1 genes can contribute to certain immune-related disorders.
- NLRP7 Gene: NLRP7 is a gene associated with recurrent hydatidiform mole, a condition characterized by abnormal growth of moles during pregnancy. The NLRP7 gene provides instructions for making a protein involved in the immune response.
Other gene and variant databases include the Genet Disease Catalog, which lists genes associated with specific diseases, and the InnateDB, which focuses on genes involved in the innate immune system. These databases are valuable resources for researchers, healthcare professionals, and individuals interested in genetic information.
References
The following references provide additional information on the NLRP7 gene and related conditions:
- Online Mendelian Inheritance in Man (OMIM) database: This resource provides a catalog of genes and genetic disorders. The entry for the NLRP7 gene can be found in OMIM database under the name “NACHT, LRR, and PYD domains-containing protein 7” (https://www.omim.org/entry/609661).
- PubMed: PubMed is a database of scientific articles. Searching for “NLRP7 gene” or related terms can yield additional research articles on this gene and its role in various conditions.
- Genetic Testing Registry: The Genetic Testing Registry provides information on genetic tests available for the NLRP7 gene and related conditions (https://www.ncbi.nlm.nih.gov/gtr/tests/?term=NLRP7).
- Genetics Home Reference: This resource provides information on genes and genetic disorders for the general public. The NLRP7 gene and related conditions are described in detail on the website (https://ghr.nlm.nih.gov/gene/NLRP7).
- National Center for Biotechnology Information (NCBI) Gene database: The NCBI Gene database provides detailed information on genes, including NLRP7. The entry for the NLRP7 gene can be found at https://www.ncbi.nlm.nih.gov/gene/203224.