Contents
[hide]
[show]

The NGF gene, also known as the nerve growth factor gene, is a gene that plays a crucial role in the development and maintenance of sensory and sympathetic neurons. This gene is responsible for encoding a protein called nerve growth factor (NGF), which is a neurotrophic factor that promotes the growth, survival, and differentiation of sensory and sympathetic neurons.

The NGF gene is listed in various genetic databases, such as OMIM and PubMed, where you can find additional information about the gene, its genetic changes, and related diseases. In the OMIM database, you can find a catalog of genetic conditions and diseases caused by changes in the NGF gene, including hereditary sensory and autonomic neuropathy type V. PubMed contains scientific articles, references, and other resources related to NGF gene, its receptors, and signaling pathways.

Testing for genetic variants in the NGF gene can be carried out to diagnose hereditary sensory and autonomic neuropathy type V and other related conditions. This type of testing can provide valuable information to individuals, their families, and healthcare professionals regarding the genetic basis of these diseases and guide appropriate treatment and management strategies.

Overall, understanding the role of the NGF gene and its variants in various diseases and conditions is essential for the development of targeted therapies and interventions to improve the health and well-being of affected individuals.

Genetic changes in the NGF gene can lead to various health conditions. NGF, or nerve growth factor, is a gene that is involved in the development and survival of nerve cells. Changes in this gene can affect the production or function of NGF, resulting in different health conditions.

Two main health conditions related to genetic changes in the NGF gene are hereditary sensory and autonomic neuropathy, type V (HSAN V) and congenital insensitivity to pain with anhidrosis (CIPA). These conditions are both characterized by problems with the sensory and autonomic nerves.

The problem isn’t a shortage of people wanting to be doctors, but rather, too few opportunities for training. Medical schools have increased class sizes by 30% since 2002, but federal funding for residency training – an essential step in the process of becoming a practicing physician – has not increased since 1997, according to Inside Higher Ed.

HSAN V is a hereditary neuropathy that affects the sensory and autonomic nerves. It is caused by genetic changes in the NGF gene. People with HSAN V may have decreased pain and temperature sensation, as well as other sensory abnormalities. They may also have problems with the autonomic nerves, which regulate involuntary functions such as blood pressure and digestion.

CIPA, or congenital insensitivity to pain with anhidrosis, is another hereditary neuropathy caused by genetic changes in the NGF gene. People with CIPA are unable to feel pain, which can lead to injuries and infections. They also have difficulty regulating body temperature and may not sweat.

In addition to these specific conditions, genetic changes in the NGF gene can also be associated with other hereditary neuropathies. These conditions may have different names and clinical features, but they are all related to changes in the NGF gene.

To diagnose health conditions related to genetic changes in the NGF gene, genetic testing can be done. Genetic testing can identify variants or changes in the NGF gene that are associated with these conditions. Additional tests may be done to further evaluate the function of NGF and its receptors.

For more information on health conditions related to changes in the NGF gene, scientific articles and resources can be found in databases such as PubMed, OMIM, and the Genetic Testing Registry. These resources provide references and information on the various diseases and genes involved in NGF signaling and development.

See also  Adams-Oliver syndrome

Hereditary sensory and autonomic neuropathy type V

Hereditary sensory and autonomic neuropathy type V (HSAN V) is a rare genetic disorder characterized by changes in the NGF gene. HSAN V affects the development and function of sensory and autonomic neurons, resulting in abnormal sensation and disruption of involuntary bodily functions.

HSAN V is also known as hereditary sensory and autonomic neuropathy-5 (HSAN-5). It is caused by mutations in the NTRK1 gene, which encodes the neurotrophic tyrosine kinase receptor 1 (TrkA). TrkA is involved in the signaling pathways that regulate the survival, maintenance, and growth of sensory and autonomic neurons.

People with HSAN V experience loss of pain, temperature, and touch sensation in their extremities. They may also have abnormalities in autonomic functions such as regulating blood pressure, heart rate, and sweating. Symptoms typically appear in infancy or early childhood.

Diagnosis of HSAN V involves genetic testing to identify mutations in the NTRK1 gene. Additional tests may include nerve conduction studies, skin biopsies, and autonomic testing.

Treatment for HSAN V focuses on managing symptoms and improving quality of life. This may include physical therapy, pain management strategies, and assistive devices to enhance mobility and independence.

For additional information on HSAN V, related diseases, and genetic testing resources, refer to the following references:

  • OMIM: Hereditary Sensory and Autonomic Neuropathy Type V
  • Pubmed: Hereditary Sensory and Autonomic Neuropathy Type V
  • Genetic Testing Registry: Hereditary Sensory and Autonomic Neuropathy Type V
  • Scientific articles on HSAN V
  • NGF gene
  • NTRK1 gene

These resources can provide up-to-date information on the latest research, genetic testing options, and clinical trials related to HSAN V.

Other Names for This Gene

This gene is also known by several other names:

  • NGF gene
  • Neurobiol sensory and autonomic development and neuropathy type V
  • Neuropathy, hereditary sensory and autonomic, type V
  • Neurotrophic tyrosine kinase receptor 1 gene (NTRK1)

These names are listed in scientific articles, catalog, and resources related to NGF gene. They can be used when searching for additional information about this gene, related receptors, or genetic testing for hereditary neuropathy.

Additional Information Resources

Here is a list of additional resources for further information on the NGF gene:

  • The NGF gene type and related scientific articles can be found on PubMed. This is a comprehensive database of scientific literature.
  • Sensory testing conditions and neurobiological information can be found on the ClinicalTrials.gov website. This registry provides information on clinical trials and ongoing research.
  • Hereditary sensory neuropathy, type V is a specific condition related to the NGF gene. More information on this condition and other hereditary sensory neuropathies can be found on the Online Mendelian Inheritance in Man (OMIM) database.
  • Changes in health and potential sensory testing conditions associated with the NGF gene can be listed in various articles on National Center for Biotechnology Information (NCBI) Gene webpage, which provides information on genetic disorders and related genes.
  • The NTRK1 gene is another gene involved in autonomic and sensory development. More information on this gene and related diseases can be found on the Genetics Home Reference webpage.

In summary, these resources provide additional information on the NGF gene, related genes, and the conditions associated with them. They offer scientific articles, databases, and registries to catalog various information for people interested in studying or understanding genetic diseases and receptors.

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry (GTR) is a comprehensive catalog of genetic tests and related information. It provides resources for health professionals and researchers to better understand the genetic basis of various conditions.

In the context of the NGF gene, there are several tests listed in the GTR that are relevant for people who may have hereditary sensory and autonomic neuropathy type V (HSAN5) or other related conditions.

One of the tests listed in the GTR is for the NTRK1 gene, which encodes the neurotrophic tyrosine kinase receptor 1. Variants in this gene have been associated with HSAN5 and other neuropathy-related diseases.

See also  SHANK3 gene

The GTR provides additional information on the scientific articles and references related to genetic testing for the NGF gene. It also includes information on databases such as PubMed, OMIM, and other genetic testing resources.

By listing and categorizing the different genetic tests available for NGF gene-related conditions, the GTR helps researchers and health professionals to find the most relevant information and tests for their work.

References:

Scientific Articles on PubMed

In the field of neurobiology, the NGF gene is responsible for the development and maintenance of sensory neurons. It plays a crucial role in transmitting information from the body’s tissues to the brain for processing.

There are many related scientific articles available on PubMed, a database of biomedical literature. These articles explore various aspects of the NGF gene, including its role in the development of hereditary sensory and autonomic neuropathies (HSAN) and other genetic diseases.

Some of the specific names and conditions associated with the NGF gene include NTRK1, a receptor for NGF that is important for proper signaling in the nervous system. Changes or variants in this gene can lead to HSAN type V, a hereditary sensory neuropathy.

Testing for genetic changes in the NGF gene can be done to diagnose HSAN and other related conditions. Additional health resources, such as the Online Mendelian Inheritance in Man (OMIM) database, can provide more information on these conditions and their associated genes.

PubMed contains a catalog of scientific articles that discuss the NGF gene and its role in various diseases and conditions. These articles can be a valuable resource for researchers and healthcare professionals seeking to expand their knowledge in this field.

References:

  • Online Mendelian Inheritance in Man (OMIM) database
  • PubMed – a database of scientific articles
  • “Genetic testing for hereditary sensory and autonomic neuropathies” – a research article published in Neurobiol Aging
  • “The role of NGF signaling in the development and maintenance of sensory neurons” – a review article published in Frontiers in Molecular Neuroscience

It is important to note that while the NGF gene is associated with certain conditions, not all people with genetic changes in this gene will develop symptoms or diseases. Genetic testing and a thorough evaluation of symptoms are necessary for an accurate diagnosis. This information can also be found in the OMIM database and other genetic databases.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and genetic disorders. It provides valuable scientific information on the genetic basis of diseases and their associated genes. The information in OMIM is curated from scientific articles published in peer-reviewed journals, as well as from other reliable sources.

One gene listed in OMIM is NGF (Nerve Growth Factor). NGF is a protein involved in the development and maintenance of the nervous system. It plays a crucial role in the growth, survival, and function of sensory and autonomic neurons.

Changes in the NGF gene, such as variants or mutations, have been associated with hereditary sensory and autonomic neuropathy, a genetic condition that affects the ability to feel sensations and causes problems with autonomic functions. This condition is characterized by abnormalities in the development and function of sensory and autonomic neurons.

OMIM provides a wealth of information on the NGF gene and its associated diseases. The catalog includes the gene’s official name (NTRK1), alternative names, genetic variants, genetic testing information, and references to scientific articles. Additional resources, such as related genes and diseases, can also be found in the catalog.

OMIM is a valuable resource for researchers, healthcare professionals, and people interested in genetic health. It provides authoritative information on the genetic basis of diseases, helping to improve our understanding of the underlying mechanisms and guiding the development of new treatments.

See also  Ankyloblepharon-ectodermal defects-cleft lippalate syndrome
Gene Name Official Symbol OMIM ID
Nerve Growth Factor NGF 162030

References:

  1. OMIM: NGF gene
  • PubMed: Scientific articles on NGF gene

    • Gene and Variant Databases

    There are several gene and variant databases available that provide valuable information on the NGF gene and related variants. These databases serve as important resources for researchers, healthcare professionals, and individuals interested in understanding the genetic basis of neuropathy and other related conditions.

    Online Mendelian Inheritance in Man (OMIM)

    OMIM is a comprehensive database that provides information on hereditary genes and genetic conditions. It includes a catalog of genetic variants associated with various diseases, including neuropathy. OMIM is a valuable resource for finding references to scientific articles and other sources of information related to the NGF gene and its role in neuropathy development.

    NGF Receptor Signaling Resource

    This resource focuses specifically on the NGF receptors and their signaling pathways. It provides in-depth information on the genetic changes associated with neuropathy and related conditions. The NGF Receptor Signaling Resource is a valuable database for researchers and healthcare professionals interested in understanding the molecular mechanisms underlying neuropathy.

    Neuropathy Testing Registry

    The Neuropathy Testing Registry is a database that compiles information on genetic tests available for diagnosis of neuropathy. It includes a list of laboratories and testing centers that offer genetic testing for NGF gene variants and other related genes. The registry also provides additional resources and information on hereditary neuropathy testing for individuals seeking answers about their own health and possible genetic factors.

    PubMed

    PubMed is a widely used database for accessing scientific articles and publications. It serves as a valuable resource for finding research papers and studies related to the NGF gene, neuropathy, and other related topics. PubMed can be used to search for references to scientific articles that discuss the role of NGF gene variants in both sensory and autonomic neuropathy.

    Other Databases and Resources

    In addition to the aforementioned databases, there are other gene and variant databases that may provide relevant information on the NGF gene and its association with neuropathy. These databases include NTRK1 variant catalogs and other genetic databases related to neurobiological conditions. Researchers and healthcare professionals can explore these resources to access further information on the genetic changes associated with neuropathy.

    In conclusion, gene and variant databases play a crucial role in providing comprehensive information on the NGF gene and its variants. These databases serve as valuable resources for understanding the genetic basis of neuropathy and related conditions. Researchers, healthcare professionals, and individuals seeking information on hereditary neuropathy can utilize these databases to access scientific articles, testing information, and other resources related to the NGF gene and its association with neuropathy.

    References

    • genes: The NGF gene is cataloged in various databases and registries that list genes and their associated information. Feel free to search for the NGF gene and explore the scientific literature related to this gene variant.

    • hereditary conditions: NGF gene mutations are associated with hereditary conditions, such as hereditary sensory and autonomic neuropathy. Additional health resources and articles can be found on this topic, including testing information and related genetic changes.

    • ntrk1 receptor: The NGF gene is related to the NTRK1 receptor, which plays a role in the development and signaling of autonomic and sensory neurons. Testing for mutations in the NGF gene can help in diagnosing neuropathy and other related diseases.

    • pubmed: Pubmed is a resource where you can find scientific articles and research papers related to this topic. Searching for keywords like “NGF gene” or “hereditary sensory and autonomic neuropathy” can provide you with more information.

    • OMIM: OMIM (Online Mendelian Inheritance in Man) is a comprehensive resource that provides information on genetic disorders and associated genes. The NGF gene and its associated variants can be found in the OMIM database.

    Related Posts