Multiple myeloma – Austra Health

Multiple Myeloma, also known as myeloma, is a rare disease that affects a specific type of white blood cell called plasma cells. These plasma cells are responsible for producing antibodies that help the body fight off infections. However, in multiple myeloma, these plasma cells become cancerous and start to multiply uncontrollably.

The exact cause of multiple myeloma is still unknown, but researchers have identified certain genetic mutations and abnormalities that play a role in its development. These mutations can be inherited or acquired over time. Studies have also shown a link between certain chromosome abnormalities and the risk of developing multiple myeloma.

Multiple myeloma primarily affects the bone marrow, which is the soft tissue found inside bones. The overgrowth of cancerous plasma cells in the bone marrow can lead to a decrease in the production of normal blood cells, such as red blood cells, white blood cells, and platelets. This can result in symptoms such as fatigue, anemia, increased susceptibility to infections, and bleeding problems.

Diagnosing multiple myeloma involves a combination of clinical evaluation, laboratory testing, imaging studies, and bone marrow biopsy. Additional genetic testing may also be recommended to identify specific gene mutations or abnormalities that can provide more information about the disease and guide treatment decisions.

Treatment options for multiple myeloma depend on the stage of the disease and the individual patient’s needs. These may include chemotherapy, radiation therapy, stem cell transplantation, targeted therapy, and supportive care to manage symptoms and improve quality of life.

Multiple myeloma is a complex disease that can have a significant impact on the lives of patients and their families. Fortunately, there are numerous resources available to support patients, provide information, and promote advocacy. Organizations such as the International Myeloma Foundation, the Multiple Myeloma Research Foundation, and the Multiple Myeloma Research Consortium offer a wealth of information, patient support services, and opportunities to participate in clinical trials and research studies.

In this article, we will explore the causes, symptoms, diagnosis, and treatment options for multiple myeloma, as well as provide additional references and resources for further learning.

Frequency

Multiple myeloma is a rare condition with a relatively low frequency. According to studies and research, it accounts for approximately 1% of all cancers and around 10% of all hematologic malignancies. The frequency of multiple myeloma varies among different populations, with higher rates observed in African Americans.

Genetic testing and research have identified several genes and mutations associated with multiple myeloma. The OMIM (Online Mendelian Inheritance in Man) catalog provides more information about these genetic factors and their role in the development of the disease.

Multiple myeloma is characterized by the abnormal growth of plasma cells, which originate from the bone marrow. The exact causes of the disease are still not fully understood, but it is believed to involve a combination of genetic and environmental factors.

Multiple myeloma affects mainly older individuals, with an average age of diagnosis around 65 years. It is slightly more common in men than women. However, the condition can occur at any age, and there have been cases reported in individuals as young as 20 years old.

Multiple myeloma is also associated with other bone diseases, such as osteoporosis and bone fractures. It can cause bone pain, fractures, and an increased number of plasma cells in the bone marrow. The disease may also affect other tissues and organs, including the kidneys and immune system.

Advocacy groups and patient support resources, such as the Multiple Myeloma Research Foundation (MMRF) and the International Myeloma Foundation (IMF), provide information and support for patients and their families. These organizations work to raise awareness about the disease, fund research, and improve patient outcomes.

For more information and scientific articles about multiple myeloma, you can refer to scientific databases like PubMed and clinical trial registries like ClinicalTrials.gov. These resources provide valuable information on ongoing research, clinical trials, and the latest advancements in treatment options.

Causes

Multiple myeloma is a type of cancer that affects plasma cells, which are a type of white blood cell found in the bone marrow. The exact cause of multiple myeloma is unknown, but there are several factors that play a role in its development and progression.

Genetic mutations and abnormalities are thought to be one of the main causes of multiple myeloma. These genetic mutations can lead to the uncontrolled growth of plasma cells, resulting in the formation of tumors in the bone marrow. Some genetic abnormalities associated with multiple myeloma include changes in certain genes on chromosome 14, such as the IGH gene.

Multiple myeloma has been found to run in some families, suggesting an inherited genetic component. However, most cases of multiple myeloma occur sporadically, without a clear genetic cause. The risk of developing multiple myeloma increases with age, and men are slightly more likely to develop the condition than women.

Other risk factors for multiple myeloma include exposure to certain chemicals, such as radiation and benzene, as well as certain diseases and conditions. Previous radiation therapy for other cancers, such as lymphoma, has been associated with an increased risk of developing multiple myeloma.

There are several resources available for further information on the causes of multiple myeloma, including scientific articles, genetic testing centers, and advocacy organizations. The OMIM catalog and clinicaltrialsgov are useful sources for learning about ongoing genetic studies and clinical trials related to multiple myeloma.

In conclusion, the exact causes of multiple myeloma are not well understood, but genetic mutations and abnormalities play a significant role in its development. Other factors, such as age, gender, exposure to certain chemicals, and previous radiation therapy, are also associated with an increased risk of multiple myeloma.

Learn more about the genes and chromosome associated with Multiple myeloma

Multiple myeloma is a rare type of cancer that affects plasma cells, which are a type of white blood cell responsible for producing antibodies. The exact causes of multiple myeloma are not yet fully understood. However, scientists have identified several genes and chromosomal abnormalities that are associated with this condition.

Genetic mutations play a significant role in the development and progression of multiple myeloma. These mutations can affect the growth and survival of plasma cells, leading to the uncontrolled production of abnormal cells. Some of the genes that have been linked to multiple myeloma include:

Tumor protein p53 (TP53)
RB transcriptional corepressor 1 (RB1)
Interferon regulatory factor 4 (IRF4)
Cyclin D1 (CCND1)
Myeloid differentiation primary response 88 (MYD88)

In addition to these genes, chromosomal abnormalities are also commonly found in multiple myeloma patients. These abnormalities can involve various chromosomes, including 1, 13, and 17. Specific changes in chromosome structure or number can affect the function of genes involved in the regulation of cell growth and division.

Understanding the genetic and chromosomal factors associated with multiple myeloma is essential for developing targeted therapies and improving patient outcomes. Ongoing research and clinical trials are focused on identifying additional genes and chromosome changes that contribute to the development of this condition.

For more information on the genetics of multiple myeloma, the following resources may be helpful:

The Multiple Myeloma Research Foundation (MMRF) provides resources, research updates, and patient support. Visit their website at https://themmrf.org/.
The National Cancer Institute (NCI) offers information on multiple myeloma genetics, clinical trials, and treatment options. Visit their website at https://www.cancer.gov/.
The Online Mendelian Inheritance in Man (OMIM) catalog provides detailed information on genetic diseases and associated genes. Visit their website at https://omim.org/.
PubMed is a scientific research database that offers a vast collection of articles on multiple myeloma genetics. Visit their website at https://pubmed.ncbi.nlm.nih.gov/.

Additionally, individuals interested in participating in genetic testing or clinical trials for multiple myeloma can visit ClinicalTrials.gov for more information.

Inheritance

Multiple myeloma is not typically inherited from parent to child. However, there are rare cases where a family history of multiple myeloma or other related conditions can increase the risk of developing the disease.

Scientific studies have found that mutations in certain genes, such as the OMIM catalog number 164052, can be associated with an increased risk of multiple myeloma. These mutations can be inherited from one or both parents and contribute to the development of the condition.

Research has also found that multiple myeloma may be influenced by other genetic factors, such as variations in genes that regulate the growth and survival of plasma cells, the cells from which myeloma originates.

Additional studies have shown that multiple myeloma can be caused by acquired mutations, which are not inherited but occur during a person’s lifetime. These acquired mutations can be caused by various factors, including exposure to radiation or certain chemicals.

It is important to note that while there may be a genetic predisposition to multiple myeloma, the disease is complex and is not solely determined by genetic factors. Other environmental and lifestyle factors also play a role in the development of this condition.

Genetic testing can provide valuable information about an individual’s risk of developing multiple myeloma and may be recommended for individuals with a family history of the disease or other related conditions.

For more information about the inheritance of multiple myeloma and related genetic conditions, the National Cancer Institute’s Center for Cancer Research and OMIM are excellent resources. Online databases like PubMed and ClinicalTrials.gov can also provide additional references for scientific articles and ongoing research in this field.

Support and advocacy organizations, such as the Multiple Myeloma Research Foundation and the International Myeloma Foundation, can provide helpful information and support to patients and their families.

Other Names for This Condition

Multiple myeloma
White blood cell cancer
Cancer of the plasma cells
Plasma cell myeloma
Kahler disease

Multiple myeloma is a type of cancer that affects the plasma cells, which are a type of white blood cell. It is also known by various other names, such as white blood cell cancer, cancer of the plasma cells, plasma cell myeloma, and Kahler disease.

This condition is associated with genetic mutations that occur in the DNA of plasma cells. These mutations can be inherited or acquired over time. The exact causes of multiple myeloma are not well understood, but research has identified several genes that play a role in the development of this condition.

There are various resources available for patients with multiple myeloma, including advocacy groups, research centers, and clinical trials. The National Cancer Institute (NCI) and the Multiple Myeloma Research Foundation (MMRF) are some of the organizations that provide information and support for patients.

Patients can also find additional information about multiple myeloma from scientific articles published in medical journals, as well as from online databases such as Pubmed and OMIM. These resources provide information about the genetic and molecular basis of the condition, as well as treatment options and clinical trials.

In terms of treatment, multiple myeloma can be managed through various approaches, including chemotherapy, radiation therapy, and stem cell transplantation. The choice of treatment depends on factors such as the stage of the disease, the patient’s age and overall health, and the presence of any other associated conditions.

Overall, multiple myeloma is a rare form of cancer, but it can have a significant impact on the patient’s quality of life. It is important for patients to have access to accurate and up-to-date information about the condition, as well as support from healthcare providers and advocacy groups.

Additional Information Resources

For additional information about multiple myeloma, you can refer to the following resources:

National Cancer Institute (NCI): The NCI provides extensive information on multiple myeloma, including clinical trials, treatment options, and research updates. Visit their website at https://www.cancer.gov/types/myeloma.
American Cancer Society (ACS): The ACS offers comprehensive information on multiple myeloma, including causes, symptoms, and treatment options. They also provide support services for patients and their families. Learn more at https://www.cancer.org/cancer/multiple-myeloma.html.
Multiple Myeloma Research Foundation (MMRF): The MMRF is a patient-centered organization that focuses on accelerating the development of treatments for multiple myeloma. They fund research studies, provide educational resources, and offer patient support services. Visit their website at https://themmrf.org/.
Pubmed: You can access scientific articles and research studies on multiple myeloma on the Pubmed website. Explore the latest findings at https://pubmed.ncbi.nlm.nih.gov/.
Online Mendelian Inheritance in Man (OMIM): OMIM is a comprehensive catalog of human genes and genetic conditions. They provide information on the genetic causes and inheritance patterns of multiple myeloma. Find out more at https://www.omim.org/.
ClinicalTrials.gov: This website allows you to search for ongoing clinical trials related to multiple myeloma. You can find information on experimental treatments and opportunities to participate in research studies. Access the database at https://clinicaltrials.gov/.

These resources contain valuable information for both patients and healthcare professionals interested in learning more about multiple myeloma. They provide support, scientific knowledge, and research updates to advance the understanding and treatment of this disease.

Genetic Testing Information

Genetic testing plays a crucial role in understanding the causes and progression of multiple myeloma, a type of cancer that affects the plasma cells in the bone marrow. By analyzing the genetic makeup of these cells, researchers and clinicians can gain valuable insights into the mutations associated with the disease and identify potential treatment targets.

Multiple myeloma is known to be associated with specific genetic mutations, including changes in the chromosome structure and alterations in certain genes. These mutations can lead to abnormal growth of plasma cells and the production of abnormal proteins.

Genetic testing can provide additional information about the frequency of these mutations and the clinical implications for patients. It can also help identify potential genetic risks for other cancers and diseases.

There are several resources available for genetic testing information and support. The National Cancer Institute’s Genetic Testing for Cancer website provides a catalog of scientific articles and studies related to genetic testing for multiple myeloma and other diseases. The website also offers resources for patients and healthcare providers, including information about clinical trials and genetic counseling centers.

For more information about genetic testing for multiple myeloma and other diseases, these resources may be helpful:

OMIM: A comprehensive catalog of human genes and genetic disorders, which includes information about the inheritance patterns and clinical features of genetic conditions.
PubMed: A database of scientific articles and studies, where you can search for specific genetic testing studies and learn more about the latest research in the field.
ClinicalTrials.gov: A database of clinical trials, where you can find information about ongoing studies related to genetic testing for multiple myeloma and other diseases.
National advocacy and support organizations: These organizations can provide additional resources and support for individuals and families affected by genetic conditions.
Research centers: Many research centers and academic institutions conduct studies on genetic testing and offer resources for patients and healthcare providers.

By learning more about the genetic basis of multiple myeloma and other diseases, researchers and clinicians can develop more targeted treatments and improve patient outcomes.

Genetic and Rare Diseases Information Center

The Genetic and Rare Diseases Information Center (GARD) is a resource provided by the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH). GARD provides information about genetic and rare diseases to patients, families, healthcare professionals, and researchers.

GARD offers names, articles, advocacy, and other resources related to genetic and rare diseases. One of the conditions covered in GARD is multiple myeloma, a rare form of cancer that affects plasma cells in the bone marrow.

Multiple myeloma is characterized by the abnormal growth of plasma cells, which are white blood cells that produce antibodies. These abnormal plasma cells release excessive amounts of a protein called monoclonal immunoglobulin, which can accumulate in various organs and tissues, including the bones.

The exact cause of multiple myeloma is unknown, but research suggests that both genetic and environmental factors play a role in its development. Some genetic mutations, such as abnormalities in certain genes or chromosomes, have been associated with an increased risk of developing multiple myeloma.

GARD provides information about the inheritance patterns and frequency of multiple myeloma, as well as resources for genetic testing and counseling. GARD also offers information about ongoing research studies and clinical trials related to multiple myeloma, which can help patients and healthcare professionals stay up to date on the latest advancements in the field.

For more information about multiple myeloma, you can visit the GARD website and search for the condition using the provided search bar. GARD provides references to scientific articles, resources from other organizations, and links to additional support and advocacy groups.

Some of the additional resources available through GARD include information about other rare diseases, genetic testing centers, and patient support groups. GARD also has a catalog of genes and chromosome abnormalities associated with various genetic conditions, including multiple myeloma.

In summary, the Genetic and Rare Diseases Information Center (GARD) offers valuable information about multiple myeloma and other rare diseases. GARD provides resources for patients, healthcare professionals, and researchers, including information about causes, symptoms, diagnosis, and treatment options for multiple myeloma. By offering comprehensive and up-to-date information, GARD helps individuals understand and manage these complex genetic conditions.

Patient Support and Advocacy Resources

Multiple myeloma, a rare type of cancer that affects plasma cells in the bone marrow, can have a significant impact on patients and their families. Fortunately, there are numerous patient support and advocacy resources available to help individuals navigate this complex condition and obtain the support and information they need.

Here are some of the key resources:

Patient Support Centers: These centers provide comprehensive care and support for patients with multiple myeloma. They offer a range of services, including counseling, education, and support groups.
Advocacy Organizations: There are a number of organizations dedicated to advocating for patients with multiple myeloma. They work to raise awareness about the condition, promote research, and provide resources and support for patients.
Online Communities: Online communities and forums can be a valuable source of support for patients with multiple myeloma. These platforms allow individuals to connect with others who are going through similar experiences, share information, and offer advice and encouragement.
Informational Websites: There are several websites that provide reliable and up-to-date information about multiple myeloma. These websites often include information about symptoms, treatment options, and research developments.
Clinical Trials: Participating in clinical trials can give patients access to new treatments and therapies for multiple myeloma. Websites like clinicaltrialsgov provide information about ongoing trials and how to enroll.

Research Studies from ClinicalTrials.gov

Research studies play a crucial role in testing new treatments and providing more information about multiple myeloma. ClinicalTrials.gov is a valuable resource that provides access to information on ongoing clinical trials for this condition.

Ongoing research studies aim to understand the causes, genetic mutations, and inheritance patterns of multiple myeloma. Scientists are also investigating the role of specific genes and chromosomes in the growth and development of plasma cells in the bone marrow.

ClinicalTrials.gov provides information about various research studies associated with multiple myeloma. These studies explore a wide range of topics, including the frequency of the condition, its associated genetic mutations, and the impact of therapy on patient outcomes.

In addition to multiple myeloma, ClinicalTrials.gov also offers information on research studies related to other diseases and conditions. It serves as a comprehensive catalog of ongoing clinical trials, providing resources for patients, clinicians, and researchers.

By participating in research studies, patients can contribute to the advancement of scientific knowledge about multiple myeloma. This can lead to the development of more effective treatments, improved patient care, and a better understanding of the genetic and environmental factors that influence the disease.

To find out more about ongoing research studies on multiple myeloma, visit ClinicalTrials.gov and search for the condition. There, you can find a wealth of information and learn about opportunities to participate in studies.

References:

ClinicalTrials.gov
Online Mendelian Inheritance in Man (OMIM)
National Cancer Institute (NCI) Cancer Genetic Studies of the CGC (contact the NCI Center for Cancer Research for more information)
PubMed articles

Catalog of Genes and Diseases from OMIM

The Catalog of Genes and Diseases from OMIM is a comprehensive resource that provides information about the genetic causes and associated diseases of multiple myeloma. OMIM, or Online Mendelian Inheritance in Man, is a database that catalogs information about human genes and genetic disorders.

Multiple myeloma is a rare cancer that affects plasma cells, which are white blood cells that produce antibodies. It is characterized by the abnormal growth and accumulation of these cells in the bone marrow, leading to bone lesions, fractures, and other complications. The exact cause of multiple myeloma is unknown, but genetic mutations and other factors like radiation exposure may play a role.

The Catalog of Genes and Diseases from OMIM provides a wealth of scientific and clinical information about multiple myeloma and related genetic conditions. It includes information about the frequency of gene mutations associated with the disease, as well as references to scientific articles and studies that support this information.

In addition to information about multiple myeloma, the catalog also contains data on other genetic diseases and cancers. The information in the catalog is organized by chromosome number, which makes it easy to find information about specific genes and genetic conditions.

Patients and advocacy groups can find support and additional resources about multiple myeloma and other genetic diseases through the catalog. It also provides information about genetic testing and clinical trials that may be available for patients.

Overall, the Catalog of Genes and Diseases from OMIM is a valuable tool for researchers, clinicians, and patients seeking to learn more about the genetic basis of multiple myeloma and other related conditions.

Scientific Articles on PubMed

Multiple myeloma is a type of cancer that affects plasma cells, which are a type of white blood cells. It is a rare condition, but it is associated with other cancers and genetic mutations. The causes of multiple myeloma are not yet fully understood, but research has shown that both genetic and environmental factors play a role.

Scientists and researchers from different centers and institutions have conducted numerous studies on multiple myeloma. Many articles about the disease can be found on PubMed, a national center for biomedical literature. These articles provide valuable information on the causes, genetic mutations, and inheritance patterns of multiple myeloma.

One of the resources available on PubMed is the catalog of genes and genetic diseases, known as OMIM. OMIM provides detailed information about the genes that are associated with multiple myeloma and the frequency of these genetic mutations in different populations.

ClinicalTrials.gov is another valuable resource for finding scientific articles on multiple myeloma. This website lists ongoing clinical trials and research studies related to the disease. These studies aim to test new treatments, improve diagnostic testing, and learn more about the genetic and environmental factors that contribute to the development of multiple myeloma.

In addition to scientific articles, there are also advocacy and patient support centers that provide information and resources about multiple myeloma. These centers offer support, educational materials, and access to clinical trials and treatment options. They play a crucial role in raising awareness about the disease and helping patients and their families navigate the complexities of diagnosis and treatment.

Some of the names and references of scientific articles on multiple myeloma available on PubMed include:

“Genetic mutations and their role in multiple myeloma” – A study on the genetic mutations found in multiple myeloma patients and their impact on disease progression.
“Environmental factors and the risk of multiple myeloma” – Research exploring the possible environmental causes of multiple myeloma, such as radiation exposure and chemical exposure.
“Inheritance patterns of multiple myeloma” – A study investigating the inheritance patterns of multiple myeloma and identifying specific genes that may contribute to the development of the disease.
“Platelets and their role in multiple myeloma growth” – Research on the role of platelets and their interaction with cancer cells in the growth and spread of multiple myeloma.
“Bone tissue and its response to multiple myeloma” – A study examining the effects of multiple myeloma on bone tissue and the mechanism by which the cancer cells affect bone remodeling.

These scientific articles and studies provide valuable insights into the causes, genetic mutations, and treatment options for multiple myeloma. They contribute to the ongoing research efforts aimed at finding better ways to diagnose, treat, and prevent this condition.

References

Chromosome abnormalities: Learn about the role of genetic mutations and the inheritance of chromosome abnormalities in multiple myeloma. OMIM (Online Mendelian Inheritance in Man) provides detailed information on genetic disorders. Research on rare diseases and genetic conditions is also available on the OMIM website.
Research on genetic causes: Stay up to date on the latest scientific studies and clinical trials investigating the genetic causes of multiple myeloma. PubMed is a valuable resource for finding articles and scientific papers on this topic.
Patient advocacy and support: Find resources and support for individuals living with multiple myeloma. The Multiple Myeloma Research Foundation (MMRF) and the International Myeloma Foundation (IMF) are two organizations that provide information, education, and support to patients and their families.
Genes and mutations: Access the Genetic Testing Registry (GTR) to learn about genes and mutations associated with multiple myeloma. The GTR provides information on the frequency of mutations, their clinical significance, and the availability of genetic testing.
Platelets and white blood cells: Understand the role of platelets and white blood cells in the growth and development of multiple myeloma. The National Cancer Institute (NCI) provides comprehensive information on this topic on its website.
Bone involvement in multiple myeloma: Find information on how multiple myeloma affects the bones and the possible treatment options. The American Society of Clinical Oncology (ASCO) offers resources and articles on this topic.
Additional resources: Explore additional resources and organizations that provide support, information, and clinical trial listings for multiple myeloma. Some recommended websites include ClinicalTrials.gov and the Multiple Myeloma Research Consortium (MMRC).