The MEOX1 gene, also known as the mesenchyme homeobox 1 gene, is a gene that plays a crucial role in the development of various tissues in the body. It is located on chromosome 17q21.32 and is involved in embryonic development. This gene is expressed in various tissues, including the paraxial mesoderm, joints, and tendons.
Changes in the MEOX1 gene have been associated with a number of health conditions and diseases. Mutations in this gene have been found to be associated with Klippel-Feil syndrome, a rare disorder characterized by the fusion of certain vertebrae in the neck. Variants in the MEOX1 gene have also been linked to other skeletal abnormalities, such as scoliosis and cervical spine anomalies.
The MEOX1 gene is included in the OMIM (Online Mendelian Inheritance in Man) catalog, which is a comprehensive database of human genes and genetic disorders. Additional information about this gene can also be found in scientific articles and references listed on PubMed, a database of biomedical literature.
Currently, the exact role of the MEOX1 gene in these conditions is unclear. Further research is needed to fully understand the function of this gene and its related pathways in health and disease. Genetic testing may be available to detect mutations in the MEOX1 gene, which can be helpful in diagnosing and managing these conditions. Other resources, such as genetic databases and registries, can provide additional information and support for individuals and families affected by these conditions.
Health Conditions Related to Genetic Changes
There are several health conditions that have been linked to genetic changes in the MEOX1 gene. However, the exact relationship between these changes and the development of these conditions is still unclear. Variants in this gene have been associated with the following conditions:
- Joint-related conditions, such as Klippel-Feil syndrome
- Other musculoskeletal diseases
The information about these conditions and their relationship to the MEOX1 gene can be found in scientific articles and databases like PubMed and OMIM. However, it is important to note that not all of the conditions listed above are directly caused by changes in this gene. Additional testing and more resources may be required to determine the exact role of the MEOX1 gene in these conditions.
Healthcare professionals can use genetic tests to identify mutations in the MEOX1 gene and determine if they are associated with any specific health conditions. These tests often involve analyzing DNA samples from patients and comparing the results to databases that contain information about known gene changes and related diseases.
For more comprehensive health information, healthcare professionals can refer to resources such as the National Human Genome Research Institute, which provides information on genetic and rare diseases, and the Genetic Testing Registry, which offers a comprehensive list of genetic tests and related information.
It is also important to consult scientific articles and references for the latest information on genetic changes related to the MEOX1 gene and associated health conditions.
Klippel-Feil syndrome
Klippel-Feil syndrome (KFS) is a genetic condition characterized by the fusion of two or more vertebrae in the neck. This fusion can result in a variety of symptoms and complications, such as restricted neck movement, abnormalities of the cervical spine, and related musculoskeletal issues.
The MEOX1 gene is one of the genes associated with Klippel-Feil syndrome. Variants or mutations in this gene can result in changes to the development of the vertebrae and joints in the neck, leading to the characteristic features of the syndrome.
Information on the MEOX1 gene and its role in Klippel-Feil syndrome can be found in scientific articles and databases. PubMed is a widely used resource for accessing articles related to genetic conditions. In addition, the Online Mendelian Inheritance in Man (OMIM) database provides information on genetic conditions, including Klippel-Feil syndrome and its associated genes.
Further information on Klippel-Feil syndrome, including testing and genetic counseling resources, can be found in related scientific publications and health databases. The Klippel-Feil Syndrome Freedom Registry is a valuable resource for individuals and families affected by the syndrome, providing support, information, and potential participation in research studies.
It should be noted that there may be additional genes and mutations that contribute to the development of Klippel-Feil syndrome, as the genetic basis of the syndrome is still not fully understood. Further research and testing are needed to fully delineate the genetic landscape of the condition.
References:
For more information on related genetic conditions and diseases, as well as additional genes and mutations, it is recommended to consult relevant scientific literature and online resources.
Other Names for This Gene
- MEOX Homeobox 1
- OAR 5.1
- Gm335
- Gm14
- GH6
The MEOX1 gene is also known by several other names:
- OAR8
- Locus
- ENSEMBL ID ENSG00000122749
- NM_168609
In addition to these names, there may be other names for this gene that are not listed here. Further scientific research may result in the discovery of more names for the MEOX1 gene.
For more information about the MEOX1 gene and related conditions, you may find the following resources helpful:
- The Genetic Testing Registry (GTR) on the Health Resources and Services Administration (HRSA) website
- The Online Mendelian Inheritance in Man (OMIM) catalog of human genes and genetic disorders
- PubMed, a database of articles on biomedical topics
- The PubMed Central (PMC) archive, which provides free access to full-text articles
- The National Library of Medicine (NLM) website, which offers a wide range of health-related information
Please note that the information provided here is subject to change. As scientific research continues, our understanding of genes, their names, and their roles in diseases may become more refined. It is always a good idea to consult with a healthcare professional for the most up-to-date information on genetic tests and related conditions.
Additional Information Resources
For more information on the MEOX1 gene, genetic testing, and related conditions, the following resources may be helpful:
- Online Mendelian Inheritance in Man (OMIM): OMIM is a comprehensive catalog of human genes and genetic diseases. It provides detailed information on the MEOX1 gene, including gene mutations and associated syndromes. You can find more information about MEOX1 by searching for its OMIM gene name, “MEOX1.”
- PubMed: PubMed is a database of scientific articles in the field of health and medical research. You can find articles on MEOX1 gene mutations and related conditions by searching for keywords like “MEOX1” or “Klippel-Feil syndrome” in the PubMed database.
- Genetics Home Reference: This online resource provides consumer-friendly information about genetic conditions and the genes associated with them. You can find more information about MEOX1 and related conditions on the Genetics Home Reference website.
- Genetic Testing Registry: The Genetic Testing Registry provides information about genetic tests for specific genes and conditions. You can search for genetic testing options for the MEOX1 gene and related conditions in the registry.
- Other Scientific Resources: There may be additional scientific articles, databases, and resources available that provide information on the MEOX1 gene and related conditions. Consult scientific journals, genetic research databases, and genetics experts for more information.
Please note that the information available on these resources may vary, and it is always important to consult with healthcare professionals and genetic experts for the most accurate and up-to-date information.
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry provides a comprehensive catalog of information about genetic tests. These tests are designed to identify changes in the MEOX1 gene and other genes related to health conditions such as Klippel-Feil syndrome. The registry includes names and information about the tests, along with references to scientific articles on the topic.
Genetic testing is a powerful tool that can detect variations, or mutations, in genes. The MEOX1 gene is associated with Klippel-Feil syndrome, a condition characterized by abnormal fusion of certain joints in the spine. By analyzing DNA, genetic testing can identify specific variants in the MEOX1 gene that may contribute to this syndrome.
In addition to the MEOX1 gene, the registry also lists tests for other genes associated with related conditions. It provides information on available tests, including which mutations or variants they detect and the specific health conditions they are associated with. The registry helps physicians and researchers stay updated on the latest developments in genetic testing.
Scientific databases such as PubMed are referenced in the registry to provide more resources and information on genetic testing. PubMed includes articles related to the MEOX1 gene and its variants, as well as other diseases and conditions. These references can be used to access additional information about the gene and its role in various health conditions.
| Registered Tests | Associated Gene | Health Conditions |
|---|---|---|
| Test 1 | MEOX1 | Klippel-Feil Syndrome |
| Test 2 | Other Genes | Related Conditions |
| Test 3 | Other Genes | Related Conditions |
- Genetic Testing Registry
- PubMed Articles
- Mutations and Variants
- OMIM
The Genetic Testing Registry provides a valuable resource for those seeking information about genetic tests and the genes they target. It allows researchers and healthcare professionals to stay updated on the latest advancements in genetic testing and the impact of gene variants on health conditions.
Scientific Articles on PubMed
PubMed is a valuable resource for finding scientific articles on various topics, including the MEOX1 gene. Researchers can use this database to search for relevant information and access a wide range of resources.
Tests for genetic variants in the MEOX1 gene and information on related diseases can be found on PubMed. The database lists articles that provide additional information on genes, mutations, and health conditions associated with the MEOX1 gene.
It is unclear if testing for variants in the MEOX1 gene can directly result in changes in health or lead to specific conditions. However, scientific articles on PubMed can provide more information on this gene and its potential implications.
One specific condition that has been linked to the MEOX1 gene is Klippel-Feil syndrome, which affects the development of the spine and may cause restricted movement in the neck and other joints. PubMed contains articles that explore the genetic basis of this syndrome and its connection to the MEOX1 gene.
When browsing PubMed, researchers can access a catalog of listed databases and search for articles specifically related to the MEOX1 gene. They can also find references to other scientific articles that might contain relevant information.
In summary, PubMed is a valuable resource for finding scientific articles on the MEOX1 gene and its associations with various health conditions. Researchers can access information on gene variant testing, related diseases, and other genes and mutations that are connected to the MEOX1 gene.
Catalog of Genes and Diseases from OMIM
The MEOX1 gene is associated with the development of Klippel-Feil syndrome. Klippel-Feil syndrome is a rare disorder characterized by the fusion of two or more vertebrae in the neck. This condition can cause a variety of symptoms, including restricted movement of the neck, abnormalities of the bones and joints in the spine, and other skeletal abnormalities.
The MEOX1 gene is responsible for providing instructions for making a protein that plays a critical role in the development of the skeleton. Mutations in this gene can result in changes to the protein’s structure or function, leading to the development of Klippel-Feil syndrome.
This catalog provides a list of genes and diseases associated with the MEOX1 gene. It includes information on the variant mutations that have been identified in this gene, as well as additional genetic changes that may contribute to the development of different conditions.
The catalog includes references to scientific articles, OMIM entries, and information from other databases. It also provides resources for additional testing and information on related conditions. Please note that the information in this catalog is for reference purposes only and should not replace medical advice or testing.
Genes Associated with Klippel-Feil Syndrome
- MEOX1
Diseases Associated with the MEOX1 Gene
- Klippel-Feil Syndrome
Variant Mutations in the MEOX1 Gene
Currently, the specific variant mutations in the MEOX1 gene that cause Klippel-Feil syndrome are unclear. Further research is needed to identify these mutations and their effects on protein function.
Additional Resources
- OMIM: The Online Mendelian Inheritance in Man database provides comprehensive information on genetic disorders. Visit OMIM
- PubMed: A database of scientific articles on a wide range of topics, including genetics and related research. Visit PubMed
- Genetic Testing Registry: A database of genetic tests and related information. Visit Genetic Testing Registry
Gene and Variant Databases
The MEOX1 gene is associated with various conditions. To gather more information about this gene and its related variants, several databases can be consulted. These databases provide scientific resources, listing the known diseases and mutations associated with the MEOX1 gene. Here are some of the databases that can be helpful in understanding the gene’s role:
- OMIM (Online Mendelian Inheritance in Man): OMIM is a comprehensive catalog of human genes and genetic disorders. It provides detailed information on the MEOX1 gene, including the associated diseases and associated variants.
- PubMed: PubMed is a database of scientific articles from various fields of research. Searching for “MEOX1 gene” on PubMed can provide additional information on studies and findings related to this gene.
- Genetic Testing Registry: The Genetic Testing Registry lists the available genetic tests for specific genes and conditions. It can provide information on the available tests for MEOX1 gene mutations.
However, it is important to note that the exact function and role of the MEOX1 gene in certain conditions may still be unclear. Further research and testing are needed to fully understand the implications of MEOX1 gene mutations on health.
References
- PUBMED: A comprehensive database providing access to scientific articles on health and related topics. It can be used to find information on the MEOX1 gene, its changes, mutations, and related diseases.
- OMIM: The Online Mendelian Inheritance in Man (OMIM) database provides information on genetic conditions and genes. It includes information on the MEOX1 gene, its variant names, and related syndromes.
- GeneTests: A resource for information on genetic testing, including testing for mutations in the MEOX1 gene and associated diseases.
- GeneReviews: A collection of articles providing in-depth information on genetic conditions, including the Klippel-Feil syndrome and its association with MEOX1 gene mutations.
- Genetic Testing Registry: This registry provides information on genetic tests available for various conditions, including testing for MEOX1 gene mutations.
- Human Gene Mutation Database: A database that collects information on human gene mutations and their association with diseases. It includes information on the MEOX1 gene and its mutations.
- NCBI Gene: The National Center for Biotechnology Information (NCBI) Gene database provides comprehensive information on genes, including the MEOX1 gene. It includes information on gene structure, function, and related diseases.