Leucovorin Injection

Leucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to to treat certain types of cancer. Leucovorin injection is used to treat people who have accidentally received an overdose of methotrexate or similar medications. Leucovorin injection is also used to treat anemia (low level of red blood cells) caused by low levels of folic acid in the body. Leucovorin injection is also used with 5-fluorouracil (a chemotherapy medication) to treat colorectal cancer (cancer that begins in the large intestine). Leucovorin injection is in a class of medications called folic acid analogs. It treats people who are receiving methotrexate by protecting healthy cells from the effects of methotrexate. It treats anemia by supplying folic acid that is needed for red blood cell formation. It treats colorectal cancer by increasing the effects of 5-fluorouracil.

🔔 How should this medicine be used?

Leucovorin injection comes as a solution (liquid) and a powder to be mixed with liquid and injected intravenously (into a vein) or into a muscle. When leucovorin injection is used to prevent harmful effects of methotrexate or to treat an overdose of methotrexate or a similar medication, it is usually given every 6 hours until laboratory tests show it is no longer needed. When leucovorin injection is used to treat anemia, it is usually given once a day. When leucovorin injection is used to treat colorectal cancer, it is usually given once a day for five days as part of a treatment that may be repeated once every 4 to 5 weeks.

🔔 Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

🔔 What special precautions should I follow?

Before receiving leucovorin injection,

• tell your doctor and pharmacist if you are allergic to leucovorin, levoleucovorin, folic acid (Folicet, in multi-vitamins), or any other medications.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain medications for seizures such as phenobarbital, phenytoin (Dilantin), and primidone (Mysoline); and trimethoprim-sulfamethoxazole (Bactrim, Septra). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have anemia (low number of red blood cells) caused by lack of vitamin B12 or inability to absorb vitamin B12. Your doctor will not prescribe leucovorin injection to treat this type of anemia.
• tell your doctor if you have or have ever had a buildup of fluid in the chest cavity or the stomach area, cancer that has spread to your brain or nervous system, or kidney disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving leucovorin injection, call your doctor.

🔔 What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.