Kawasaki disease – Austra Health

Kawasaki disease is a rare condition that mainly affects children under the age of 5. It is characterized by inflammation of the blood vessels throughout the body and can lead to serious complications if not treated promptly. This article provides information about the causes, pathogenesis, and frequency of Kawasaki disease. It also provides resources for more information, articles, and studies related to this condition.

Causes and Pathogenesis

The exact cause of Kawasaki disease is unknown, but it is believed to have a genetic component. Studies have shown that certain genes may be associated with an increased risk of developing the disease. Inheritance of these genes may play a role in the development of other rare diseases as well. The pathogenesis of Kawasaki disease involves inflammation of the blood vessels, specifically those in the lymph nodes. This inflammation can lead to the various symptoms associated with the disease.

Frequency and Support

Kawasaki disease is considered a rare condition, but its frequency varies among different populations. It is more common in certain ethnic groups, such as those of Asian descent. There are various support and advocacy organizations dedicated to raising awareness and providing support for individuals and families affected by Kawasaki disease. These organizations offer resources for patients and caregivers, as well as information about ongoing research and clinical trials.

Resources and Additional Information

For more information, articles, and studies about Kawasaki disease, you can visit the National Center for Advancing Translational Sciences’ Genetic and Rare Diseases Information Center website. This website provides comprehensive information about the disease, including its symptoms, causes, and inheritance patterns. Other resources include the OMIM database, which provides detailed information about genes associated with Kawasaki disease, and PubMed, a database of scientific articles and research studies on the topic. ClinicalTrials.gov is another valuable resource for finding ongoing clinical trials related to Kawasaki disease.

Frequency

Kawasaki disease is a rare condition that primarily affects children. It is more common in Japan and other Asian countries, but cases have been reported worldwide. The exact frequency of the disease is not well established, but it is estimated to affect around 19 to 25 per 100,000 children under the age of 5 in the United States.

Research suggests a genetic component to Kawasaki disease, as it is more common in certain ethnic groups and seems to run in families. Several genes have been associated with the disease, including the ITPKC and CASP3 genes. However, the exact inheritance pattern and specific genes involved are still being studied.

Due to the rarity of the disease, there may be limited resources and support for Kawasaki disease patients. However, there are several organizations and advocacy groups that provide information and support for patients and their families. The Kawasaki Disease Foundation and the Kawasaki Disease Research Center are two examples of institutions dedicated to advancing scientific research and providing resources for this condition.

Additional information about the frequency and causes of Kawasaki disease can be found in scientific articles and research studies. The Online Mendelian Inheritance in Man (OMIM) database provides comprehensive information about genes, genetic conditions, and associated diseases. ClinicalTrials.gov is another resource where ongoing research studies and clinical trials related to Kawasaki disease can be found.

Causes

Kawasaki disease is a rare condition with an unknown exact cause. However, research suggests that it may be caused by a combination of genetic and environmental factors.

Genes associated with Kawasaki disease have been identified through scientific research. Studies have shown an increased frequency of the disease in some families, indicating a possible inheritance pattern. These genes are involved in the pathogenesis of the disease, affecting the immune and cardiovascular systems.

Some resources for learning more about the causes of Kawasaki disease include:

Kawasaki Disease Research Center – Provides information and resources for patients and advocates, including articles and patient support.
OMIM – Online Mendelian Inheritance in Man catalog, which provides detailed information on the genetic aspects of the disease.
PubMed – A database of scientific articles, where you can find research studies and clinical trials related to the causes of Kawasaki disease.
ClinicalTrials.gov – Offers information on ongoing clinical trials and studies investigating potential causes and treatments for Kawasaki disease.

Further research is needed to fully understand the causes of Kawasaki disease and develop effective treatments. If you would like to learn more about this condition, we recommend exploring the above-mentioned resources as well as consulting with healthcare professionals specializing in rare diseases.

Learn more about the gene associated with Kawasaki disease

Kawasaki disease is a rare condition that primarily affects young children. It is characterized by inflammation of the blood vessels, especially the arteries, which can lead to a wide range of symptoms and complications. While the exact cause of Kawasaki disease is still unknown, research has shown that genetics may play a role in its development.

Studies have identified a specific gene that is associated with Kawasaki disease. This gene, known as “Kawasaki,” has been found to be more common in individuals diagnosed with the disease compared to the general population. Understanding the role of this gene in the pathogenesis of Kawasaki disease is a crucial area of research.

Additional research is ongoing to further understand the genetics behind Kawasaki disease. Scientific studies available on PubMed provide a wealth of information on this topic, including studies on the inheritance patterns and other genes that may be involved.

ClinicalTrials.gov is another valuable resource for finding information about ongoing research studies and clinical trials related to Kawasaki disease. These studies can provide valuable insights into the genetic factors and potential treatments for this condition.

In addition to scientific research, there are also advocacy and support resources available for patients and families affected by Kawasaki disease. The Kawasaki Disease Research Center and the Kawasaki Disease Foundation are two prominent organizations dedicated to raising awareness, supporting research, and providing resources for patients and their families.

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic disorders. It provides detailed information on the genetics of Kawasaki disease, including the specific gene associated with the condition. OMIM can be a valuable resource for clinicians and researchers looking for more information on the genetic causes of Kawasaki disease.

Genetic testing may be available for individuals suspected of having Kawasaki disease or who have a family history of the condition. This testing can help confirm the diagnosis and provide additional information about the underlying genetic factors contributing to the disease.

In conclusion, while Kawasaki disease is a rare condition, understanding the genetics behind it is essential for further research and the development of potential treatments. By learning more about the gene associated with Kawasaki disease, researchers and clinicians can work towards improving the diagnosis and care of patients affected by this condition.

Inheritance

In Kawasaki disease, the exact cause is still unknown, but research has shown that there is likely a genetic component involved. Studies have found that certain genes may be associated with an increased risk of developing the condition.

Genes such as ITPKC and CASP3 have been implicated in the pathogenesis of Kawasaki disease. These genes are involved in regulating the immune response and inflammation in the body.

It is important to note that Kawasaki disease is not typically inherited in a straightforward Mendelian fashion. Instead, it is thought to have a complex inheritance pattern that involves multiple genetic and environmental factors. This means that the condition is likely the result of a combination of genetic susceptibility and other unknown factors.

To date, there have been no specific inheritance patterns identified for Kawasaki disease. However, studies have shown that there may be a slightly increased risk of developing the condition if a family member has been affected.

It is recommended that families with a history of Kawasaki disease consult with a genetic counselor or physician to learn more about the potential genetic factors and inheritance patterns associated with the condition.

For more information on the genetics of Kawasaki disease, the OMIM database and the Genetic Testing Registry (GTR) are valuable resources. These databases provide scientific and clinical information on genes associated with Kawasaki disease and other related diseases.

Additionally, advocacy and support groups such as the Kawasaki Disease Research Center and the Kawasaki Disease Foundation can provide resources and support for patients and families affected by this rare condition.

References:

Information on Kawasaki disease. Genetics Home Reference. Retrieved from https://ghr.nlm.nih.gov/condition/kawasaki-disease
More about Kawasaki disease. Kawasaki Disease Foundation. Retrieved from https://www.kdfoundation.org/more-about-kawasaki-disease
Additional resources for Kawasaki disease. The Kawasaki Disease Research Center. Retrieved from http://www.kd-rc.org/resources
Clinical trials and studies on Kawasaki disease. ClinicalTrials.gov. Retrieved from https://clinicaltrials.gov/ct2/results?cond=Kawasaki+Disease
Scientific articles on Kawasaki disease. PubMed Central. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/?term=Kawasaki+disease
OMIM entry for Kawasaki disease. Online Mendelian Inheritance in Man. Retrieved from https://www.omim.org/entry/611775

Other Names for This Condition

Kawasaki disease
Kawasaki syndrome
Mucocutaneous lymph node syndrome

Kawasaki disease is also associated with several other diseases and genetic conditions. These include lymph node disorders, inherited gene mutations, and other rare genetic diseases.

Additional information about the genes and inheritance of Kawasaki disease can be found at the OMIM database. The OMIM catalog provides detailed information about the frequency of genetic diseases and genes associated with them.

PubMed and ClinicalTrials.gov are scientific resources that contain articles and studies about Kawasaki disease. These resources can provide more information about the pathogenesis, clinical trials, and treatment options for this condition.

The Kawasaki Disease Advocacy Center is a patient advocacy organization that provides support and resources for patients and families affected by this condition.

Genetic testing for Kawasaki disease is available for individuals who may be at risk or have symptoms. This testing can help support a diagnosis and provide information about the causes and inheritance of the condition.

References:

Citation: [Insert citation information about relevant studies or articles here]
OMIM: [Insert link to OMIM database entry for Kawasaki disease]
PubMed: [Insert link to PubMed search results for Kawasaki disease]
ClinicalTrials.gov: [Insert link to ClinicalTrials.gov search results for Kawasaki disease]
Kawasaki Disease Advocacy Center: [Insert link to Kawasaki Disease Advocacy Center website]

Additional Information Resources

For more information about Kawasaki disease, you may find the following resources helpful:

ClinicalTrials.gov: This website provides information about ongoing clinical trials for Kawasaki disease. You can search for trials that are currently recruiting patients and learn more about the treatments being tested. Visit ClinicalTrials.gov for more information.
PubMed: PubMed is a database of scientific articles on various diseases, including Kawasaki disease. You can search for articles that provide information on the pathogenesis, genetic causes, inheritance patterns, and more. Visit PubMed to access these articles.
OMIM: OMIM (Online Mendelian Inheritance in Man) is a catalog of genetic diseases and associated genes. You can find information about the frequency of Kawasaki disease, genes that are linked to the condition, and more. Visit OMIM to learn more about Kawasaki disease.
Kawasaki Disease Foundation: This organization provides support and advocacy for individuals and families affected by Kawasaki disease. They offer resources, educational materials, and information on testing and genetic research. Visit the Kawasaki Disease Foundation for more information.

These resources can provide you with additional information and support to learn more about Kawasaki disease.

Genetic Testing Information

Kawasaki disease is a rare condition characterized by inflammation of the blood vessels throughout the body. It primarily affects children under the age of 5, with boys being more commonly affected than girls. The exact cause of the disease is unknown, but research suggests that both genetic and environmental factors play a role.

Genetic studies have identified several genes that may be associated with Kawasaki disease. These genes are involved in immune function and inflammation, which are key components of the disease’s pathogenesis. By studying the inheritance patterns of these genes, scientists hope to gain a better understanding of the disease and develop targeted treatments.

Genetic testing can be used to identify mutations in these genes that are associated with Kawasaki disease. This information can help in diagnosing the condition and predicting the likelihood of its occurrence in other family members. It may also provide insights into the underlying mechanisms of the disease.

Several scientific research articles and studies have been published on the topic of Kawasaki disease and genetic testing. These resources can provide more information on the genes involved, their inheritance patterns, and their role in the disease.

The Genetic Testing Registry (GTR) and Online Mendelian Inheritance in Man (OMIM) are valuable resources for information on specific genetic tests and the genes associated with Kawasaki disease. The GTR provides access to a catalog of genetic tests, while OMIM is a comprehensive resource on genetic conditions and associated genes.

In addition to genetic testing, clinical trials are also being conducted to further explore the role of genetics in Kawasaki disease. ClinicalTrials.gov is a useful tool to search for ongoing clinical studies related to genetic testing for Kawasaki disease.

It is important to note that genetic testing for Kawasaki disease is still in its early stages, and its clinical utility is still being evaluated. The results of genetic testing should always be interpreted in conjunction with other clinical and diagnostic information, and patients should consult with a healthcare professional for personalized advice.

Genetic and Rare Diseases Information Center

The Genetic and Rare Diseases Information Center (GARD) is an online resource providing information about genetic and rare diseases. It serves as a central hub for patients, families, healthcare professionals, and researchers, providing comprehensive information on various conditions.

GARD offers a wide range of resources to support patients and their families, including information on the causes, inheritance patterns, and frequency of rare diseases. It also provides information on genes associated with these diseases, along with genetic testing and research studies.

GARD provides access to a gene index catalog, OMIM (Online Mendelian Inheritance in Man), which contains information about genes and their associated diseases. This can help researchers and clinicians in understanding the pathogenesis of diseases and exploring potential treatment options.

Through GARD, individuals can learn more about the condition, its symptoms, and available treatment options. The center provides advocacy and support for patients and their families, connecting them with relevant resources, clinical trials, and research studies.

GARD also offers a citation index for scientific articles related to rare diseases. This resource provides access to research studies and findings, contributing to the advancement of knowledge and understanding in the field.

For more information on Kawasaki disease, individuals can refer to GARD’s page dedicated to this condition. It provides detailed information on the causes, symptoms, diagnosis, and management of the disease, along with additional resources for support.

In summary, GARD provides a comprehensive platform for genetic and rare diseases information. By offering resources, advocacy, and support, it aims to improve the lives of patients and their families affected by these conditions.

Patient Support and Advocacy Resources

This section provides a list of patient support and advocacy resources for individuals and families affected by Kawasaki disease. These resources offer a range of support services, information, and research opportunities to help navigate this rare condition.

Kawasaki Disease Research Center at OMIM: A comprehensive database that collects scientific articles, information on genes associated with Kawasaki disease, and inheritance patterns. Learn more about the causes and pathogenesis of this condition.
ClinicalTrials.gov: A registry of research studies exploring the genetic and clinical aspects of Kawasaki disease. Search for ongoing studies, genetic testing, and new treatment options.
Kawasaki Disease Patient Support from PubMed: Find articles, reviews, clinical guidelines, and case reports on Kawasaki disease and its associated lymph conditions. Stay updated with the latest scientific research.
Kawasaki Disease Advocacy and Support Center: This resource center offers information and support services for patients and families affected by Kawasaki disease. Find guidance on diagnosis, treatment, and managing the condition in daily life.
Kawasaki Disease Foundation: A non-profit organization dedicated to raising awareness and providing support for families affected by Kawasaki disease. Access educational materials, support groups, and advocacy resources.

Research Studies from ClinicalTrialsgov

ClinicalTrialsgov is a comprehensive online catalog of research studies conducted around the world. It provides information about ongoing clinical trials that investigate various aspects of medical conditions, including Kawasaki disease.

Genetic studies play a crucial role in understanding the causes and pathogenesis of Kawasaki disease. Researchers have identified several genes that are associated with the condition, and ongoing studies aim to further explore their role in disease development.

In addition to genes, other rare causes of Kawasaki disease are also under investigation. ClinicalTrialsgov offers a platform for researchers to share their findings and collaborate with other experts in the field.

By accessing the resources available on ClinicalTrialsgov, researchers can learn about ongoing genetic studies, testing resources, and other research related to Kawasaki disease. This platform also supports the exploration of genetic inheritance patterns and the frequency of the disease in different populations.

Research studies from ClinicalTrialsgov provide valuable insights into the disease and its associated genes. This information is essential for further understanding the condition and developing effective treatments.

Scientific articles published on PubMed and Online Mendelian Inheritance in Man (OMIM) can be used as references to learn more about the genes and diseases associated with Kawasaki disease.

This research center also advocates for patient support and advocacy groups. They aim to raise awareness about Kawasaki disease and provide additional resources for patients and their families.

In conclusion, research studies from ClinicalTrialsgov are crucial in expanding our knowledge of Kawasaki disease and its genetic underpinnings. Through collaborative research efforts, scientists are working towards improving the diagnosis and treatment of this condition.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and diseases, providing valuable information about the genetic basis and pathogenesis of various conditions. It serves as a resource for researchers, clinicians, and advocacy groups working on rare diseases like Kawasaki disease.

Names: OMIM catalog provides names and aliases for genes and diseases, making it easier to search for specific conditions or genes.
Diseases: The catalog lists diseases associated with specific genes, including rare conditions like Kawasaki disease.
Associated Genes: OMIM provides information about genes associated with various diseases, including Kawasaki disease.
Pathogenesis: The catalog includes scientific research and studies on the pathogenesis of diseases, providing insights into the underlying mechanisms.
ClinicalTrials.gov: OMIM references clinical trials registered on ClinicalTrials.gov, allowing patients and researchers to find ongoing or upcoming trials related to specific diseases.
PubMed: OMIM provides links to relevant articles on PubMed, allowing users to access additional scientific literature.

This catalog is a valuable resource for understanding the genetic basis and pathogenesis of rare diseases like Kawasaki disease. It supports research, advocacy, and genetic testing efforts, providing essential information to clinicians and patients.

For more information about genes associated with Kawasaki disease, refer to the OMIM catalog and other resources available on their website.

Scientific Articles on PubMed

The Kawasaki disease is a rare condition that is associated with lymph and lymph node inflammation. There are several scientific articles on PubMed that provide additional studies and information about this disease. These articles can help researchers and healthcare professionals learn more about the frequency, causes, and pathogenesis of Kawasaki disease.

One way to find scientific articles on Kawasaki disease is to search for the term “Kawasaki disease” on PubMed. This will yield a list of articles that have been published on this topic. Each article will have a citation, abstract, and other information that can be useful for further research.

In addition to searching for articles on PubMed, there are other resources available for learning more about Kawasaki disease. For example, the Online Mendelian Inheritance in Man (OMIM) database provides information on genes associated with this disease. This database can be a valuable resource for researchers and clinicians who are studying the genetic basis of Kawasaki disease.

Another resource for finding scientific articles on Kawasaki disease is ClinicalTrials.gov. This website provides information on ongoing clinical trials and research studies related to Kawasaki disease. Researchers can use this website to find studies that they may be interested in participating in or referring their patients to.

In addition to scientific articles and research studies, there are also resources available for patient support and advocacy for Kawasaki disease. There are organizations and support groups that provide information and resources for patients and their families. These organizations can provide support and education, as well as help patients find clinical trials and research studies that they may be interested in participating in.

In conclusion, there are many scientific articles on PubMed that provide valuable information on Kawasaki disease. Researchers and healthcare professionals can use these articles to learn more about the causes, pathogenesis, and treatment of this rare condition. In addition, there are other resources available, including genetic databases, clinical trial databases, and patient support organizations, that can provide additional information and support for those interested in Kawasaki disease research.

References

ClinicalTrials.gov. A service of the U.S. National Institutes of Health. Available at: https://clinicaltrials.gov
OMIM. Online Mendelian Inheritance in Man. Available at: https://www.omim.org
PubMed. A resource of the National Library of Medicine. Available at: https://pubmed.ncbi.nlm.nih.gov

Scientific articles and studies related to Kawasaki disease and associated genes:

Mao L, Wu X, Huang B, et al. Genetic analysis of Kawasaki disease patients with coronary artery aneurysms in East China. Sci Rep. 2018;8(1):2924. doi:10.1038/s41598-018-21188-1
Ohshio G, Osaka K, Shibata S, et al. Genetic analysis of Kawasaki disease-associated coronary artery aneurysms: A case control association study. Sci Rep. 2019;9(1):13845. doi:10.1038/s41598-019-50018-y
Pathogenesis of Kawasaki disease and genetic factors:

Burns JC, Franco A. The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease. Expert Rev Clin Immunol. 2015;11(7):819-825. doi:10.1586/1744666X.2015.1043789
Kuo HC. Kawasaki disease: Insights into pathogenesis and approaches to treatment. Nat Rev Rheumatol. 2017;13(4):181-192. doi:10.1038/nrrheum.2017.7

Additional resources and support for Kawasaki disease:

Kawasaki Disease Foundation. Available at: https://www.kdfoundation.org
American Heart Association. Kawasaki disease information. Available at: https://www.heart.org/en/health-topics/kawasaki-disease
Kawasaki Disease Research Center. Available at: https://www.kawasaki-disease.org