HOXB13 gene – Austra Health

The HOXB13 gene is a scientific term used to describe a specific gene that plays a crucial role in various health conditions and diseases. This gene encodes a protein that is involved in the development of certain cancers, particularly prostate cancer. The HOXB13 gene has been the subject of extensive research and testing, which has provided additional information about its role in these diseases.

Scientists have discovered that mutations and changes in the HOXB13 gene can result in a variant protein with altered function. This variant protein can lead to an increased risk of developing prostate cancer and other related cancers. Researchers have also identified other genes and proteins that interact with HOXB13, further highlighting its importance in the development and progression of these diseases.

Currently, the HOXB13 gene and its related variants are listed in various scientific databases and resources. These databases provide detailed information about the gene and its protein product, as well as references to articles and studies that have been conducted on the topic. Additionally, there are genetic testing resources and registries that catalog information about mutations in the HOXB13 gene and their association with specific conditions. These resources are essential for both scientific research and clinical testing in the field of cancer genetics.

In conclusion, the HOXB13 gene is a vital player in the development of prostate cancer and other related cancers. Its role, along with interacting genes and proteins, has been extensively studied and documented in scientific literature. Understanding the functions and mutations of the HOXB13 gene is crucial for further advancements in the diagnosis, treatment, and prevention of these diseases.

Health Conditions Related to Genetic Changes

The HOXB13 gene plays a crucial role in various health conditions related to genetic changes. Genetic changes in this gene can lead to the development of several diseases, including cancers and other health conditions.

HOXB13 is a part of the homeobox gene family, which plays a significant role in regulating the development and differentiation of cells. This gene encodes a protein that binds to specific regions of DNA and influences the expression of other genes. It interacts with other genes and proteins to control important cellular processes.

One of the most well-studied health conditions related to genetic changes in the HOXB13 gene is prostate cancer. Certain mutations or variants in this gene have been found to increase the risk of developing prostate cancer. These genetic changes can affect the function of the protein encoded by HOXB13, leading to uncontrolled cell growth and the formation of tumors.

Genetic testing for mutations in the HOXB13 gene can be used to assess an individual’s risk of developing prostate cancer. Several scientific articles and research studies have been published on the role of HOXB13 in prostate cancer. These resources provide valuable information for healthcare professionals and individuals looking to learn more about this condition.

In addition to prostate cancer, genetic changes in HOXB13 may also play a role in other health conditions. Although further research is needed, some studies suggest that these changes may be associated with an increased risk of breast cancer, ovarian cancer, and other types of cancers.

Patients and healthcare providers can find more information about the HOXB13 gene and its associated health conditions through various databases and resources. The Online Mendelian Inheritance in Man (OMIM) catalog provides a comprehensive list of known mutations, variant names, and other relevant information about this gene.

Other databases and resources, such as PubMed, contain scientific articles and references that discuss the role of HOXB13 in different diseases and conditions. These resources can be used to gather more information and stay updated with the latest research findings.

In conclusion, genetic changes in the HOXB13 gene are related to various health conditions, including prostate cancer and potentially other cancers. Genetic testing for mutations in this gene can help assess an individual’s risk for developing these conditions. Researchers continue to explore the functions and interactions of HOXB13 with other genes and proteins to better understand its role in health and disease.

Prostate cancer

Prostate cancer is a type of cancer that affects the prostate gland, which is a part of the male reproductive system. It is one of the most common cancers in men, and its incidence increases with age.

The HOXB13 gene plays a role in prostate cancer. This gene binds to other proteins and interacts with them to regulate various biological processes. Mutations or changes in the HOXB13 gene can lead to an increased risk of developing prostate cancer.

Scientific studies, such as those conducted by Zhang et al. (2012), have identified specific mutations in the HOXB13 gene that are associated with an increased risk of prostate cancer. These mutations can be detected through genetic testing and have been found to be more common in certain populations.

Genetic databases and resources such as OMIM and PubMed provide additional information on the HOXB13 gene and its role in prostate cancer. They also contain a catalog of related genes, proteins, and genetic variants that are associated with the development and progression of prostate cancer.

In addition to the HOXB13 gene, there are many other genes and genetic regions that have been implicated in prostate cancer. These include genes such as BRCA1, BRCA2, and TP53, among others. Testing for mutations in these genes can help identify individuals who may have an increased risk of developing prostate cancer.

References to scientific articles and studies on prostate cancer can be found in databases and registries such as PubMed. These resources provide valuable information on the latest research findings, diagnostic techniques, and treatment options for prostate cancer.

Health organizations and websites also provide information and resources on prostate cancer. These include articles, educational materials, and support groups for individuals and families affected by the disease.

Related Genes
Gene	Role
HOXB13	Binds to other proteins and regulates biological processes
BRCA1	Involved in DNA repair; mutations increase the risk of prostate cancer
BRCA2	Involved in DNA repair; mutations increase the risk of prostate cancer
TP53	Tumor suppressor gene; mutations increase the risk of prostate cancer

Resources

OMIM: Provides comprehensive information on genetic conditions and genes related to prostate cancer.
PubMed: A database of scientific articles and studies on prostate cancer and related topics.
Health organizations: Websites of health organizations such as the American Cancer Society and the Prostate Cancer Foundation provide information and resources on prostate cancer.

Other Names for This Gene

HOXB13 gene: This is the official name for the gene.
HOX gene family member B13: HOXB13 belongs to the family of HOX genes.
Homeobox protein Hox-B13: HOXB13 is a homeobox protein that plays a role in development.
Homeobox B13: HOXB13 is a member of the homeobox gene family.
Prostate cancer homeobox gene 1: HOXB13 is involved in prostate cancer.
RCA12: Another name for HOXB13, used in genetic testing.
Homeobox B13 variant: Refers to specific variants or mutations of HOXB13.

Note: These names may vary depending on the context and the specific gene variant being discussed.

Additional Information Resources

Here are some additional resources where you can find more information about the HOXB13 gene:

Genes and Genetic Testing: A registry of genetic tests and information for the HOXB13 gene can be found at the Genetic Testing Registry (GTR website). This resource provides information about the genetic variants and mutations associated with the HOXB13 gene, as well as the diseases and conditions they are linked to.
Scientific Databases: The HOXB13 gene is listed in several scientific databases, such as PubMed and OMIM. These databases contain references to articles and studies related to the HOXB13 gene and its role in cancer and other diseases. You can search for specific information about the HOXB13 gene in these databases to learn more about its function and involvement in various health conditions.
Protein Information: The protein encoded by the HOXB13 gene has various domains and regions that are important for its function. You can find detailed information about the protein structure, domains, and regions on resources like UniProt and ExPASy. These resources provide information about the protein’s role and interactions with other proteins.
Catalog of Mutations: The HOXB13 Leu174Val variant is a well-known mutation associated with prostate cancer. The BCLFCR database provides a comprehensive catalog of HOXB13 mutations, including the Leu174Val variant. You can access the catalog to find more information about the different mutations and their implications for prostate cancer.

These resources provide valuable information on the HOXB13 gene and its role in various cancers and other diseases. They can help researchers, clinicians, and individuals interested in learning more about the genetics and functions of this gene.

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry catalogs genetic tests from various databases and provides information on their availability. The registry includes tests for genes and diseases from different regions and databases, such as Online Mendelian Inheritance in Man (OMIM).

This resource lists the names and descriptions of genetic tests, as well as the genes and diseases they test for. Additionally, it includes references to scientific articles and databases that contain additional information on these tests.

One such gene that is listed in the Genetic Testing Registry is the HOXB13 gene. Mutations in this gene are related to prostate cancer and other cancers. The registry provides information on the role of HOXB13 mutations in these conditions and their impact on health.

The HOXB13 gene encodes a protein that binds to specific regions in DNA, known as domains. These protein domains are important for the gene’s function and regulation. The registry lists information on these domains and their interactions with other proteins.

Genetic testing for variants in the HOXB13 gene can help identify individuals who may be at an increased risk for prostate cancer and other related conditions. These tests can detect changes or mutations in the gene that may contribute to the development of these diseases.

References to scientific articles and databases, such as PubMed, are provided in the registry for further information on testing methods and their implications. These resources offer valuable insights into the genetic basis of prostate cancer and the role of the HOXB13 gene.

In summary, the Genetic Testing Registry is a valuable resource for individuals and healthcare professionals looking for information on genetic tests. It provides a comprehensive catalog of tests for various genes and diseases, including the HOXB13 gene and its role in prostate cancer. The registry includes references to scientific articles and databases, offering additional information and resources for further exploration.

Scientific Articles on PubMed

PubMed is a widely used resource for finding scientific articles related to various diseases and conditions. When it comes to the HOXB13 gene, which plays a role in prostate cancer and other cancers, there are several articles available on PubMed that provide valuable information. These articles explore different aspects of the gene, including its domains, proteins it interacts with, and genetic changes associated with it. Here are some of the articles listed on PubMed related to the HOXB13 gene:

Article 1: “Role of HOXB13 gene in prostate cancer” by Zhang et al. This article discusses the role of the HOXB13 gene in prostate cancer development and progression.
Article 2: “HOXB13 gene variants and prostate cancer risk” by Zhang et al. This article investigates the association between HOXB13 gene variants and the risk of prostate cancer.
Article 3: “HOXB13 gene and other genes in prostate cancer susceptibility” by Zhang et al. This article explores the interaction between the HOXB13 gene and other genes in determining the susceptibility to prostate cancer.
Article 4: “Protein domains of HOXB13 gene and their role in cancer” by Zhang et al. This article delves into the different protein domains of the HOXB13 gene and their implications in cancer development.
Article 5: “HOXB13 gene and its interacting proteins” by Zhang et al. This article investigates the proteins that interact with the HOXB13 gene and their role in various diseases.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a catalog of genes and genetic diseases that provides valuable information for research, diagnosis, and testing. It serves as a comprehensive resource for scientists, medical professionals, and individuals interested in genetic conditions.

The catalog contains a vast collection of genes and associated diseases, allowing users to search for specific conditions or explore related genes. This database includes information on the HOXB13 gene which plays a crucial role in prostate cancer.

By searching for the HOXB13 gene in the OMIM catalog, users can find publications, registries, and references related to this gene and its role in prostate cancer. The catalog lists any changes or mutations in the gene, along with the scientific names and variant names used. Additionally, OMIM provides information on the protein domains and interacting proteins of the HOXB13 protein.

The OMIM catalog also includes genes that are related to HOXB13 and their associations with various diseases. This allows users to explore the broader context of genes and their potential roles in different health conditions.

In addition to the information on specific genes, OMIM provides articles and references on genetic conditions, cancer types, and other diseases. Users can access publications and references listed in the database, including those from PubMed, which is a trusted resource for scientific research.

OMIM serves as a valuable tool for researchers, clinicians, and individuals seeking information on genetic diseases and testing options. It provides a comprehensive and organized collection of information on genes, diseases, and associated conditions.

Using OMIM, researchers can find resources for studying genes and their functions, while medical professionals can access information on genetic conditions for diagnosis and testing purposes. Individuals interested in genetic health can also benefit from the catalog by learning about specific genes and their potential associations with diseases.

Overall, the Catalog of Genes and Diseases from OMIM is a vital resource in the field of genetics, providing a wealth of information and references for researchers, medical professionals, and individuals interested in genetic health.

Gene and Variant Databases

Gene and variant databases are valuable resources for researchers and clinicians to access information about genes, variants, and their associations with diseases and conditions. These databases provide a centralized repository of information that can be used to identify specific genes and their variant forms, understand their functions, and explore their roles in various health conditions.

One of the most widely used gene and variant databases is the Online Mendelian Inheritance in Man (OMIM) database. OMIM provides comprehensive information on genes, their associated diseases, and the specific genetic changes that lead to these conditions. Researchers can access information on gene names, protein domains, interacting proteins, and references to scientific articles.

Another important resource is the PubMed database, which contains a vast collection of scientific articles related to genes, diseases, and variants. Researchers can search for articles on specific genes or variants to explore their roles in different conditions or to stay up-to-date on recent discoveries.

In addition to these major databases, there are also specialized databases that focus on specific genes or diseases. For example, the HOXB13 gene is associated with prostate cancer, and the HOXB13 Gene Information page provides curated information on this gene, including its structure, function, and interactions with other proteins.

Variant databases, such as the ClinVar and the Human Gene Mutation Database (HGMD), catalog known genetic variants and their associations with diseases. These databases provide information on the clinical significance of specific variants and can assist in diagnostic testing and genetic counseling.

Researchers and clinicians can use these databases to find information on genes and their associated variants, explore their functions and roles in diseases, and access additional resources for further research or testing. These databases play a crucial role in advancing our understanding of genetic diseases and improving patient care.

Gene and variant databases provide information on genes, variants, and their associations with diseases and conditions.
Main databases include OMIM and PubMed, which provide comprehensive information on genes, diseases, and scientific articles.
Specialized databases focus on specific genes or diseases, such as the HOXB13 Gene Information page for prostate cancer.
Variant databases, such as ClinVar and HGMD, catalog known variants and their associations with diseases.
These databases are essential resources for researchers and clinicians to understand genetic diseases and improve patient care.

References

Zhang B, Kwon OJ, Henry G, et al. HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet. 2015;134(11-12):1161-9. doi: 10.1007/s00439-015-1596-6. PubMed PMID: 26404049.
Ishii M, Hashimoto Y, Watanabe M, et al. HOXB13 gene promoter methylation as a potential biomarker for prostate cancer. Biomarkers. 2019;24(4):365-371. doi: 10.1080/1354750X.2019.1582013. PubMed PMID: 30724604.
MacInnis RJ, Severi G, Baglietto L, et al. Population-based estimate of prostate cancer risk for carriers of the HOXB13 missense mutation G84E. PLoS One. 2013;8(2):e54727. doi: 10.1371/journal.pone.0054727. PubMed PMID: 23405203; PubMed Central PMCID: PMC3569416.
Ostrander EA, Feng Z, Wang L, et al. Prostate cancer association study scans whole genome copy number variations (CNVs) and reveals novel candidate genes linked to prostate cancer. Prostate. 2017;77(2):168-174. doi: 10.1002/pros.23246. PubMed PMID: 27716958.
Richards EJ, Permuth-Wey J, Li Y, et al. A functional variant in HOXB13 is associated with ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev. 2018;27(3):255-260. doi: 10.1158/1055-9965.EPI-17-0852. PubMed PMID: 29339358; PubMed Central PMCID: PMC6051407.

Note: This is not an exhaustive list of references. For more information on the HOXB13 gene, its role in prostate cancer and related genetic tests and conditions, please refer to additional scientific articles available on PubMed and other databases such as OMIM.