Tumor myeloma is a type of cancer that affects plasma cells, which are a kind of white blood cell. This condition is characterized by the abnormal growth of these cells in the bone marrow, leading to the formation of tumors. Tumor myeloma can cause various symptoms, including bone pain, fatigue, and an increased risk of infections.

Seevohwinkel syndrome is a rare genetic condition that affects the skin, hair, and nails. People with this syndrome often have thickened skin on the palms of their hands and soles of their feet, as well as hyperkeratosis, which is an excessive production of keratin. Additionally, Seevohwinkel syndrome can cause hearing loss, vision problems, and other complications.

De Vries syndrome, also known as bulbar palsy with deafness, is a genetic condition that affects the nerves in the brainstem. This syndrome can cause weakness and paralysis of the muscles in the face, throat, and tongue, leading to difficulties in swallowing, speaking, and breathing. De Vries syndrome is often associated with hearing loss and other neurological symptoms.

Kidney stones, also known as renal calculi, are hard deposits that form in the kidneys. These stones can be made up of various substances, such as calcium, uric acid, and oxalate. Kidney stones can cause severe pain, blood in the urine, and urinary tract infections. Certain genetic conditions, such as cystinuria and primary hyperoxaluria, can increase the risk of developing kidney stones.

Kindler syndrome is a genetic condition that affects the skin and mucous membranes. People with this syndrome often have fragile skin that blisters easily in response to minor trauma or friction. Kindler syndrome can also lead to pigmentation changes, scarring, and an increased risk of skin cancer. Additionally, this condition can affect the oral cavity, esophagus, and other internal organs.