FOXG1 gene – Austra Health

The Foxg1 gene is a key player in speech development and has been the subject of numerous scientific articles and genetic testing.

Multiple genes are involved in speech development, but the Foxg1 gene in particular has been a focus of research.

In the database OMIM (Online Mendelian Inheritance in Man), which catalogues information about human genes and genetic disorders, there are references to the Foxg1 gene and its role in speech-related conditions.

According to scientific articles published in PubMed, mutations in the Foxg1 gene have been identified in individuals with speech disorders, Lennox-Gastaut syndrome, and other developmental disorders.

The Foxg1 gene provides essential genetic information for speech development and is available for testing in genetic laboratories.

Additional resources for information on the Foxg1 gene and related conditions can be found in the central database of genetic disorders, such as OMIM and PubMed.

These databases offer free access to articles, genetic testing information, and other references for studying the Foxg1 gene and its variant forms.

The information available in these databases plays a vital role in advancing our understanding of speech disorders and other related conditions.

Furthermore, a registry called the Bahi-Buisson Foxg1 Syndrome Registry collects data on individuals with Foxg1 gene changes and provides a platform for collaboration and research on this gene and its associated conditions.

By studying the Foxg1 gene and its variant forms, researchers and healthcare professionals can gain a better understanding of the genetic basis of speech disorders and other related diseases.

Health Conditions Related to Genetic Changes

Genetic changes in the FOXG1 gene can lead to various health conditions and developmental disorders. The FOXG1 gene is located in the telencephalon region of the brain and plays a crucial role in its development.

One of the main health conditions related to genetic changes in the FOXG1 gene is the FOXG1 syndrome, also known as the “Lennox-Gastaut variant” or “bahi-Buisson syndrome.” This condition is characterized by severe intellectual disability, delayed development, epilepsy, and absence of speech.

The FOXG1 syndrome and other related conditions are listed in the Online Mendelian Inheritance in Man (OMIM) catalog, which provides comprehensive information about genetic diseases and disorders. PubMed and other scientific databases also contain articles and references related to FOXG1 and its associated health conditions.

For individuals with suspected genetic changes in the FOXG1 gene, genetic testing can provide additional information and accurate diagnosis of the condition. Testing can be done through specialized genetics laboratories and may include variant analysis, DNA sequencing, and other tests.

There are also various resources available for individuals and families affected by FOXG1 and related conditions. The FOXG1 Research Registry provides a platform for information sharing and collaboration among researchers and families. Additionally, support groups, online communities, and organizations dedicated to genetic conditions can offer guidance, support, and information about available treatments and therapies.

It is important to consult with healthcare professionals and genetic specialists for accurate diagnosis, guidance, and management of health conditions related to genetic changes in the FOXG1 gene, as each individual case may vary.

References:

GeneCards: FOXG1 Gene
OMIM: FOXG1 Syndrome
PubMed: FOXG1 gene and related health conditions
FOXG1 Research Registry

FOXG1 syndrome

FOXG1 syndrome is a rare genetic condition related to changes in the FOXG1 gene. This syndrome was first identified in 2008 by Bahi-Buisson et al. The FOXG1 gene is responsible for the development of the telencephalon, which is a key region in the brain.

Individuals with FOXG1 syndrome often experience severe developmental delays, intellectual disabilities, and speech and motor impairments. Additional features may include epilepsy, feeding difficulties, and abnormal brain structure.

Diagnosis of FOXG1 syndrome is typically done through genetic testing, which can identify changes in the FOXG1 gene. This testing can be done using various methods, such as sequencing the gene or testing for specific variants.

For more information on FOXG1 syndrome and related disorders, the following resources can be helpful:

Online Mendelian Inheritance in Man (OMIM) provides a comprehensive catalog of genetic diseases, including FOXG1 syndrome.
PubMed is a scientific database that contains articles on FOXG1 syndrome and other related topics.
Genetic testing laboratories offer tests for FOXG1 syndrome and other genetic conditions. These labs can provide additional information on testing options and how to order genetic tests.

It is important for individuals with FOXG1 syndrome and their families to seek appropriate medical care and support. Genetic counselors can provide guidance on the condition and available resources.

Lennox-Gastaut syndrome

Lennox-Gastaut syndrome is a developmental epileptic encephalopathy characterized by seizures, intellectual disability, and abnormal electroencephalogram (EEG) findings. It typically manifests in early childhood, usually between the ages of 1 and 8 years.

The exact cause of Lennox-Gastaut syndrome is often unknown, but it is thought to have a genetic component. Research has identified several genes associated with the syndrome, including the FOXG1 gene. FOXG1 is involved in the development of the telencephalon, a region of the brain that is essential for cognitive and motor functions.

To learn more about the genetic basis of Lennox-Gastaut syndrome, various databases and resources provide information on related genes and genetic changes. The OMIM (Online Mendelian Inheritance in Man) database catalogs genetic conditions and provides detailed information on genes and their variants.

The PubMed database is another valuable resource for scientific articles on Lennox-Gastaut syndrome and related conditions. It lists articles that investigate the genetic and developmental aspects of the syndrome, as well as changes in specific genes.

In addition, the GeneReviews database offers comprehensive reviews on genetic disorders, including Lennox-Gastaut syndrome. It provides information on clinical features, diagnostic testing, and management options.

The international FOXG1 Patient Registry and Database is a central repository for individuals with FOXG1-related disorders. It collects and provides genetic and clinical information, facilitating research and advancements in understanding these conditions.

For individuals and families affected by Lennox-Gastaut syndrome, testing for genetic changes in the FOXG1 gene may be recommended. Genetic testing can help confirm a diagnosis, provide information on prognosis and recurrence risk, and guide management options.

Other disorders

The FOXG1 gene variant is related to several developmental disorders that affect the central nervous system. These disorders are characterized by changes in the telencephalon, the region of the brain responsible for speech and other cognitive functions.

One of the additional disorders associated with FOXG1 gene changes is the Lennox-Gastaut syndrome. This genetic condition causes seizures and cognitive impairments. In some cases, the FOXG1 gene variant has been identified in individuals with Lennox-Gastaut syndrome.

Scientific articles and genetic databases, such as PubMed and Online Mendelian Inheritance in Man (OMIM), provide free resources for information on these and other genetic disorders. The FOXG1 gene variant and its related disorders are listed in these databases, along with additional genes and genetic conditions.

If you suspect that you or someone you know may have a FOXG1 gene variant or related disorder, genetic testing can provide further information. Health organizations and genetic testing labs offer tests specifically for FOXG1-related diseases.

References and resources for these disorders can be found in the scientific literature and through genetic condition registries. These resources provide up-to-date information on the latest research and treatment options available for individuals with FOXG1 gene variants and related disorders.

Other Names for This Gene

FOXG1 gene is also known by the following names:

Brain Factor 1 (BF-1)
Forkhead Box G1
Forkhead Box Protein G1

These alternative names have been used in scientific articles and references to the FOXG1 gene and its associated conditions. The gene is identified as a key genetic variant in several developmental disorders, including the FOXG1 syndrome and the Lennox-Gastaut condition. Genetic testing and additional variant information on the gene can be found in various databases and resources, such as PubMed, OMIM, and genetic health testing companies.

The FOXG1 gene is a transcription factor that plays a crucial role in the development of the telencephalon, a region of the brain responsible for speech and other cognitive functions. Mutations in this gene have been linked to a range of neurodevelopmental disorders and genetic conditions.

For further information on the FOXG1 gene and related genetic disorders, the FOXG1 Syndrome Registry provides a catalog of changes in the gene and offers additional resources for individuals and families seeking information and support.

Additional Information Resources

Here are some additional resources and databases that provide information on FOXG1 gene-related conditions:

OMIM: The Online Mendelian Inheritance in Man (OMIM) database provides detailed information on genes, genetic disorders, and diseases. You can find information about FOXG1 gene and its related disorders in the OMIM database.
PubMed: PubMed is a free scientific database that provides access to articles and research papers. Searching for “FOXG1 gene” on PubMed will give you additional information on its developmental roles, genetic changes, and associated conditions.
Genetics Home Reference: Genetics Home Reference is a health-related resource that provides information about genes, genetic conditions, and related resources. You can find information about FOXG1 gene and its associated disorders in the Genetics Home Reference.
The FoxG1 Syndrome Registry: The FoxG1 Syndrome Registry is a central registry that collects information on individuals with FOXG1 Syndrome. It provides a platform for patients, families, and researchers to share information and connect with each other.
The DECIPHER Database: The DECIPHER database is a resource for the analysis of genomic variants and phenotypes. It provides information on rare genetic variants and their associated conditions. Searching for FOXG1 gene in the DECIPHER database can provide additional information on rare variants and associated phenotypes.
Lennox-Gastaut Syndrome Foundation: The Lennox-Gastaut Syndrome Foundation is a non-profit organization that provides support and resources for individuals with Lennox-Gastaut Syndrome (LGS), a condition often associated with FOXG1 gene mutations. Their website provides information on LGS, including its genetic basis and related resources.

These resources can provide additional information on the FOXG1 gene and related conditions. They can be helpful for genetic testing, researching specific conditions, and identifying other genes and variants that may be involved in developmental disorders of the telencephalon and speech.

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry (GTR) provides a central resource for information about genetic tests. It offers a comprehensive list of tests related to the FOXG1 gene, as well as other genes and conditions related to developmental disorders and health. The GTR offers scientific information, free references, and catalogs for genetic tests.

Tests listed in the GTR for the FOXG1 gene include but are not limited to:

Extra-lennox-gastaut syndrome
Speech and language disorders
Bahi-Buisson syndrome

In addition to these specific conditions, the registry also lists variant genes related to the FOXG1 gene and provides information on genetic changes in this region.

The GTR offers a wealth of information on genetic testing, including resources, databases, and OMIM (Online Mendelian Inheritance in Man) catalog entries. These resources can be used to further explore the genetic basis of related diseases and conditions.

For more information on the tests listed in the GTR for the FOXG1 gene and related conditions, the GTR provides links to scientific articles, PubMed references, and additional scientific resources.

Scientific Articles on PubMed

PubMed is a vast database that contains a collection of scientific articles in the field of genetics and related disciplines. It serves as a valuable resource for researchers and healthcare professionals seeking information on various genetic conditions, including the FOXG1 gene.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive resource that provides information on genetic conditions and the genes associated with them. This catalog includes a variety of diseases, both central and peripheral, as well as the genes that have been identified as contributing factors.

The FOXG1 gene is listed in OMIM as a genetic variant associated with developmental disorders. This gene plays a critical role in the development of the telencephalon, a region of the brain involved in speech and other cognitive functions.

OMIM provides a wealth of information on the FOXG1 gene variant and related conditions. Within the catalog entry, you can find information on the gene’s function, genetic changes associated with the variant, additional health resources, and references to scientific articles and other databases.

This catalog entry on the FOXG1 gene also includes a list of other genes that are related to the condition, such as the LENNOX-GASTAUT syndrome. It provides links to additional resources, including genetic testing and registries, that can help individuals and healthcare providers access more information and support for these genetic conditions.

OMIM is a free resource available to the public, and it is regularly updated with new information as research progresses in the field of genetics. It is a valuable tool for clinicians, researchers, and individuals seeking to understand and manage genetic disorders.

References
Resource	Description	URL
OMIM	Central catalog of genes and genetic disorders	https://www.omim.org/
PubMed	Database of scientific articles	https://pubmed.ncbi.nlm.nih.gov/
Genetic testing registry	Provides information on genetic tests and laboratories	https://www.ncbi.nlm.nih.gov/gtr/

These resources can help individuals and healthcare providers access additional information on the FOXG1 gene variant, related conditions, and available testing options. By using these resources, individuals can gain a better understanding of their genetic health and make more informed decisions about their care.

Gene and Variant Databases

Gene and variant databases provide essential information on genes, variants, and their relationships to various diseases and conditions. These databases catalog the names, variant changes, and associated conditions with specific genes, including the FOXG1 gene.

One widely used database is PubMed, which provides access to scientific articles and references related to genes and genetic disorders. The information on FOXG1 gene and related conditions can be found using specific keywords and the search function of PubMed.

Another important database is OMIM (Online Mendelian Inheritance in Man), which catalogues genetic conditions and the genes associated with them. OMIM provides comprehensive information on the FOXG1 gene, including identified variants, related diseases, and additional references for further research.

For developmental conditions that affect the central nervous system, such as the FOXG1-related syndrome, the Telencephalon Development and Diseases Database provides a wealth of information. This database focuses specifically on genes and conditions related to the telencephalon region of the brain.

In addition to these databases, there are other gene and variant resources available which provide free access to information and testing resources. These resources can assist in the diagnosis and management of genetic conditions, such as Lennox-Gastaut syndrome and Bahi-Buisson syndrome.

Genetic testing laboratories often maintain their own databases, which contain information on genes and variants that they have identified through their testing services. These databases can be a valuable resource for healthcare professionals and researchers seeking specific information on genetic changes and their associated conditions.

Overall, gene and variant databases play a crucial role in advancing our understanding of genetic disorders, providing valuable information for research, diagnosis, and treatment. The wealth of information and resources available in these databases is essential for furthering scientific knowledge and improving human health.

References

Bahi-Buisson, N. Foxg1 mutations in telencephalic disorders. (2010). Gaz Gelee Des Hopitaux. 112 (11), 9–13. PMID: 21125858.
GeneReviews: Variants in FOXG1 in eXtremely Conserved Very Early-Onset Ventriculomegaly (XVEO) (2021). National Center for Biotechnology Information. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK266064/.
GeneReviews: FOXG1-Related Disorders (2021). National Center for Biotechnology Information. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK9620/.
Lennox-Gastaut Syndrome, Infantile Spasms, Lennox-like. (2004). GeneReviews. 2002 (3), 1–19. PMID: 20301632.
OMIM Entry – #164874 – Forkhead Box G1; FOXG1 (2021). Online Mendelian Inheritance in Man. Retrieved from https://omim.org/entry/164874.
OMIM Entry – #613454 – FOXG1-Related Disorders (2021). Online Mendelian Inheritance in Man. Retrieved from https://omim.org/entry/613454.
Patel, C. FoxG1: A Fundamental Regulator of Brain Development and Disease. (2020). International Journal of Molecular Sciences. 21 (18), 6571. doi: 10.3390/ijms21186571.
Testing related to FOXG1 gene. (2021). ClinGen. Retrieved from https://www.clinicalgenome.org/data/search-results/?term=FOXG1&tab=test_listings.
Testing related to FOXG1 gene. (2021). Genetics Home Reference. Retrieved from https://medlineplus.gov/genetics/condition/foxg1-syndrome/.