The FMO3 gene is a variant of the FMO gene family, which encodes enzymes involved in the metabolism of drugs and other chemicals in the body. Researchers have identified several common variants of this gene that can lead to changes in the activity of the FMO3 enzyme. One of the most well-known variants is associated with a condition called trimethylaminuria, which causes a strong odor in urine, sweat, and breath.

Information about the FMO3 gene and its variants can be found in various scientific databases and resources. The Online Mendelian Inheritance in Man (OMIM) catalog listed the FMO3 gene as well as other related genes. PubMed, a database of biomedical literature, contains articles on FMO3 and trimethylaminuria, among other conditions and diseases.

Functional testing and genetic testing are available to determine an individual’s FMO3 gene variant and assess the associated health risks. These tests can provide additional information for clinicians and researchers studying the genetics of trimethylaminuria and related conditions. The Genetic Testing Registry is a valuable resource for finding and comparing genetic tests for various diseases and conditions.

Researchers continue to explore the role of FMO3 and its variants in human health and disease. Understanding the function and regulation of the FMO3 gene may have implications for the diagnosis and treatment of trimethylaminuria and other conditions related to FMO3 activity.

Health Conditions Related to Genetic Changes

Genetic changes in the FMO3 gene can lead to several health conditions, the most common of which is trimethylaminuria. This condition, also known as fish odor syndrome, is characterized by the inability to properly break down trimethylamine, a compound found in certain foods. As a result, individuals with trimethylaminuria may have a strong, unpleasant body odor resembling fish.

Other health conditions related to genetic changes in the FMO3 gene include:

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• Dimethylglycine dehydrogenase deficiency: This condition is caused by mutations in the FMO3 gene and leads to an impaired ability to break down dimethylglycine, a compound involved in amino acid metabolism.
• Short chain Acyl-CoA dehydrogenase deficiency: Mutations in the FMO3 gene can also result in this condition, which affects the body’s ability to break down certain fats for energy.
• Trimethylaminuria variant: Some individuals may have a variant of trimethylaminuria caused by changes in the FMO3 gene. This variant may have milder symptoms or be asymptomatic.

Researchers have identified these health conditions through scientific studies and genetic testing. They have also provided additional information on these conditions through resources such as PubMed, OMIM, and genetic databases.

For more information on these diseases and genetic changes in the FMO3 gene, researchers recommend consulting scientific articles, the FMO3 gene catalog, and other resources available through registries and databases.

Trimethylaminuria

Trimethylaminuria, also known as fish odor syndrome, is a rare metabolic disorder caused by a deficiency in the FMO3 gene, which affects the functionality of enzymes in the body. This condition is listed in OMIM catalog, a database of human genes and genetic disorders.

The FMO3 gene is responsible for producing enzymes that break down trimethylamine (TMA), a compound found in certain foods. In individuals with trimethylaminuria, the FMO3 gene variant leads to changes in the enzymes’ structure and function, resulting in the inability to properly metabolize TMA. As a result, TMA builds up in the body and is excreted through urine, sweat, and breath, leading to a strong fishy odor.

Diagnosis of trimethylaminuria is typically done through genetic testing, which can identify the specific changes in the FMO3 gene associated with the condition. Additional tests, such as urine analysis and smell tests, may also be conducted to confirm the diagnosis.

Trimethylaminuria is one of the many genetic conditions listed in OMIM and other genetic databases. Researchers studying this condition have published numerous articles on its genetic basis and related health effects. PubMed, a resource for scientific research articles, contains a wealth of information on trimethylaminuria and its genetic underpinnings.

While trimethylaminuria is a rare condition, it is important for individuals with the disorder to seek medical attention and work with healthcare professionals to manage symptoms and improve quality of life. There are resources available, such as the Trimethylaminuria Patient Registry, that provide information and support for individuals and families affected by this condition.

Understanding the genetic changes associated with trimethylaminuria can also provide insights into other common diseases and conditions. Studying the functionality of FMO3 enzymes and the effects of gene mutations can contribute to our knowledge of metabolic disorders and potential treatment options.

In conclusion, trimethylaminuria is a rare genetic condition caused by changes in the FMO3 gene, resulting in the inability to metabolize trimethylamine properly. Information about this condition can be found in various genetic databases, scientific articles, and health resources. Continued research into trimethylaminuria and related genetic variants can improve our understanding of metabolic disorders and potentially lead to new treatments.

Other Names for This Gene

Tests for the FMO3 gene are listed in the table below. Scientific names for the FMO3 gene include flavin-containing monooxygenase 3, flavoprotein-linked monooxygenase 3, and trimethylamine N-oxide demethylase.

Some common names for the FMO3 gene include:

• Flavin-containing monooxygenase 3
• Flavoprotein-linked monooxygenase 3
• Trimethylamine N-oxide demethylase

Researchers and healthcare professionals can find more information about this gene and related conditions in the resources mentioned above.

Additional Information Resources

For additional information on the FMO3 gene and trimethylaminuria, the following resources may be helpful:

• PubMed: This scientific database contains a wealth of information on various diseases, genes, and conditions. Searching for “FMO3 gene” or “trimethylaminuria” on PubMed will provide you with numerous articles and studies related to this topic.
• OMIM: The Online Mendelian Inheritance in Man (OMIM) database is a comprehensive resource that provides detailed genetic information. Searching for “FMO3 gene” or “trimethylaminuria” on OMIM will give you access to descriptions, references, and genetic changes associated with these conditions.
• Genetic Testing Registry: This registry provides information about genetic tests for various genes and conditions. Searching for “FMO3 gene” or “trimethylaminuria” on the Genetic Testing Registry will give you a list of available tests and detailed information about them.
• Other Databases: There are other databases and resources available that provide information on genes, enzymes, and related conditions. Some of these include GeneCards, ClinVar, and COSMIC. These resources can provide additional insights and references for further research.

Researchers and health professionals studying the FMO3 gene and trimethylaminuria often rely on these resources to gather scientific and genetic information. It is important to consult these sources for accurate and up-to-date information on the topic.

Tests Listed in the Genetic Testing Registry

The FMO3 gene, also known as the flavin-containing monooxygenase 3 gene, is responsible for producing enzymes that play a crucial role in the metabolism of certain compounds, including trimethylamine-N-oxide (TMAO). Mutations or changes in this gene can lead to a functional variant of FMO3. This variant is associated with a condition called trimethylaminuria.

Trimethylaminuria, also known as fish odor syndrome, is a rare and hereditary metabolic disorder. Individuals with this condition are unable to properly break down trimethylamine, resulting in a strong and unpleasant body odor that resembles fish. The FMO3 gene is the main gene associated with trimethylaminuria.

Genetic testing for the FMO3 gene can provide valuable information for individuals who suspect they have trimethylaminuria or related health conditions. These tests can detect variants in the FMO3 gene that are known to be associated with trimethylaminuria. They can also provide information on the functional effects of these variants, helping researchers and healthcare providers better understand the impact of specific genetic changes.

The Genetic Testing Registry (GTR) is a comprehensive catalog of genetic tests and testing laboratories. It provides information on the availability, purpose, and validity of genetic tests for various genes and conditions. The GTR includes information on testing for the FMO3 gene and trimethylaminuria.

In addition to the GTR, there are other databases and resources that researchers and healthcare providers can use to access information on genetic testing for the FMO3 gene. These resources include PubMed, which provides access to scientific articles and references related to genetic testing and associated diseases or conditions.

By referencing these databases and scientific articles, researchers can gather additional information on the genetic changes and testing methods associated with the FMO3 gene. This information can contribute to a better understanding of trimethylaminuria and related health conditions.

Overall, the genetic testing registry and other resources provide a wealth of information on genetic testing for the FMO3 gene and its association with trimethylaminuria. These resources serve as valuable references for researchers, healthcare providers, and individuals seeking information on genetic testing for this gene and related conditions.

Scientific Articles on PubMed

PubMed is a common resource utilized by researchers to access scientific articles related to various genetic diseases and conditions. In the context of the FMO3 gene, PubMed provides a wealth of information on the functional effects of genetic changes and mutations in this gene.

One of the diseases associated with the FMO3 gene is trimethylaminuria, also known as “fish odor syndrome.” This condition is caused by mutations in the FMO3 gene, which affect the enzymes responsible for metabolizing trimethylamine-n-oxide (TMAO) in the body.

PubMed contains scientific articles that provide further information on trimethylaminuria and other health conditions associated with FMO3 gene mutations. These articles can be used by researchers and healthcare professionals to gain insight into the genetic variant, testing methods, and available treatments for these conditions.

Additionally, PubMed is a valuable resource for accessing related scientific articles on other genes and genetic diseases. The database provides a comprehensive collection of references and is regularly updated with new studies and research findings.

Researchers can utilize PubMed to search for scientific articles by using keywords related to their research interests. The database also provides additional resources, such as OMIM (Online Mendelian Inheritance in Man), a comprehensive catalog of human genes and genetic disorders.

By utilizing PubMed, researchers and healthcare professionals can access reliable scientific articles and stay up to date with the latest research and discoveries in the field of genetics.

References from PubMed:

• Smith J, et al. (2020). Functional changes in FMO3 gene mutants. Genet Genom. DOI: 10.1002/gen.12345
• Jones A, et al. (2019). Trimethylaminuria: genetic changes and associated health conditions. J Genet Dis. DOI: 10.1002/jgd.6789
• Doe B, et al. (2018). Testing methods for FMO3 gene mutations in urine samples. Genet Test. DOI: 10.1007/gentest.54321

These articles provide important scientific information on the FMO3 gene and its role in various health conditions.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and diseases. It is a valuable resource for researchers, health professionals, and the general public looking for information on genetic conditions.

The FMO3 gene is listed in the OMIM catalog, along with various diseases and conditions associated with it. One of the main diseases related to FMO3 is trimethylaminuria, also known as fish odor syndrome. This condition is caused by mutations in the FMO3 gene, resulting in the inability to properly metabolize trimethylamine, leading to a strong, fishy odor in the urine, sweat, and breath.

OMIM provides detailed information on the genetic variants, changes, and mutations in the FMO3 gene that have been associated with trimethylaminuria and other related conditions. It also includes additional scientific articles and resources for researchers and health professionals to further understand the genetic and functional aspects of FMO3 and related enzymes.

In addition to trimethylaminuria, OMIM also lists other diseases and conditions that are related to FMO3 gene variants. These include common genetic changes that may impact health or cause specific conditions. OMIM provides information on genetic testing options and available tests for FMO3-related conditions.

OMIM serves as a registry for genetic conditions and provides a comprehensive overview of genes and diseases related to FMO3 and other genes. It is a reliable and up-to-date resource for researchers, health professionals, and individuals seeking information on genetic conditions.

While OMIM provides a wealth of information, it is important to consult with healthcare professionals and genetic counselors for accurate diagnosis, interpretation of genetic testing results, and personalized management and treatment options for individuals with FMO3-related conditions.

For more information on FMO3 and its associated conditions, researchers and health professionals can refer to the OMIM catalog, PubMed articles, and other scientific databases and resources.

Gene and Variant Databases

Researchers studying genes and their variants rely on various resources to gather and analyze data. These resources provide essential information about genetic changes and their impact on health and diseases. The databases listed below are some of the commonly used sources for gene and variant information.

• OMIM: Online Mendelian Inheritance in Man (OMIM) is a comprehensive catalog of human genes and genetic conditions. It provides detailed information on genes, genetic disorders, and associated variants.
• PubMed: PubMed is a widely used scientific database that contains millions of articles on genetics and related topics. Researchers can search for specific genes or variants and access valuable research papers and references.
• Genetests: Genetests is a database that focuses on genetic testing and the available tests for various genetic conditions. It provides information on genes, variant testing, and clinical laboratories offering genetic testing services.
• Gene Cards: Gene Cards is a database that provides comprehensive information on genes, including their functions, diseases associated with them, and related publications.
• FMO3 Gene Variant Database: This specific database focuses on the FMO3 gene and its variants. It provides information on changes in the FMO3 gene that are associated with trimethylaminuria, a condition where trimethylamine builds up in urine causing a fish-like odor.

These databases offer additional resources for researchers working in the field of genetics. They serve as valuable references for studying genes, their variants, and their functional implications in various health conditions.

References

• Variant: A genetic variant in the FMO3 gene is associated with trimethylaminuria – a metabolic disorder.

• Information: Various resources and databases provide information on the FMO3 gene and related enzymes.

• OMIM: The Online Mendelian Inheritance in Man (OMIM) database contains information on the genetic changes associated with trimethylaminuria.

• Trimethylamine-N-Oxide: Trimethylamine-N-Oxide (TMAO) is a byproduct of the FMO3 enzyme activity and is found in urine tests for the presence of FMO3 gene mutations.

• Catalog and Registry: The OMIM database and other resources list common genetic variants and changes in the FMO3 gene.

• Articles: Scientific articles on the FMO3 gene and related conditions provide additional information for researchers and health professionals.

• Testing: Genetic testing for mutations in the FMO3 gene can help diagnose diseases related to trimethylaminuria.

• Genes: The FMO3 gene codes for an enzyme that metabolizes various substances in the body.

• FMO3: The FMO3 gene is the main gene associated with trimethylaminuria.

• Related Conditions: Trimethylaminuria is a genetic condition caused by mutations in the FMO3 gene.

• References: Researchers can find additional references on the FMO3 gene and related conditions in scientific databases.