Fluconazole Tablets

NOTES: Not applicable.

fluconazole 150 mg – oral, Diflucan

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GENERIC NAME: FLUCONAZOLE 150 MG – ORAL (floo-KON-a-zole)

BRAND NAME(S): Diflucan

USES: Fluconazole is used to treat vaginal yeast infections. It works by stopping the growth of common types of vaginal yeast (fungus). This medication belongs to a class of drugs called azole antifungals.

HOW TO USE: Read the Patient Information Leaflet before you start taking fluconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.In Canada, some brands of this medication are available without a prescription. Before taking over-the-counter fluconazole, read the product instructions and talk to your doctor if this is your first vaginal yeast infection, if this is your second infection within 2 months, or if you are considering treatment for a girl under 12 years old.Take this medication by mouth usually as a single dose, with or without food at any time of the day, or as directed by your doctor.The effect of this medication continues for several days. If your condition does not improve after a few days or if it worsens, or if you think you may have a serious medical problem, get medical help right away.

SIDE EFFECTS: Nausea, diarrhea, stomach pain, headache, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.If your doctor has directed you to use this product, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using the product do not have serious side effects.Get medical help right away if any of these rare but serious side effects occur: fast/irregular heartbeat, severe dizziness, fainting.This drug may rarely cause serious liver disease. Get medical help right away if you develop any signs of liver disease, including: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine, unusual tiredness.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking fluconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal drugs (such as ketoconazole, itraconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease.Fluconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using fluconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using fluconazole safely.Although uncommon, this drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Higher daily doses of fluconazole (more than the single-dose treatment for vaginal yeast infections) may harm an unborn baby if taken during the first 3 months of pregnancy.Fluconazole passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.Products that may interact with this drug include: clopidogrel.Many drugs besides fluconazole may affect the heart rhythm (QT prolongation), including pimozide, quinidine, macrolide antibiotics (such as erythromycin), among others.Fluconazole can slow down the removal of other medications from your body, which can affect how they work. An example of the affected drugs is cisapride, among others.

QUESTION

OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: hallucinations, mental/mood changes.

NOTES: Not applicable.

MISSED DOSE: Not applicable.

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Fluconazole Tablets

Medically reviewed by Drugs.com. Last updated on Aug 23, 2022.

Uses of Fluconazole Tablets:

• It is used to treat fungal infections.
• It is used to prevent fungal infections.
• This medicine is used to treat vaginal yeast infections.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Fluconazole Tablets?

• If you have an allergy to fluconazole or any other part of this medicine (fluconazole tablets).
• If you are allergic to this medicine (fluconazole tablets); any part of this medicine (fluconazole tablets); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you are taking any of these drugs: Astemizole, cisapride, erythromycin, olaparib, pimozide, quinidine, terfenadine, or voriconazole.
• If you are pregnant or may be pregnant. You will need to talk with your doctor about if this medicine (fluconazole tablets) is right for you.

This is not a list of all drugs or health problems that interact with this medicine (fluconazole tablets).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (fluconazole tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Related/similar drugs

What are some things I need to know or do while I take Fluconazole Tablets?

• Tell all of your health care providers that you take this medicine (fluconazole tablets). This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (fluconazole tablets) affects you.
• Do not use longer than you have been told. A second infection may happen.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Talk with your doctor before you drink alcohol.
• Very bad skin problems like rashes have happened with this medicine (fluconazole tablets). Sometimes, this has been deadly in people with other bad health problems. Talk with the doctor.
• Very bad liver problems have rarely happened with this medicine (fluconazole tablets). Sometimes, this has been deadly in people with other bad health problems. Talk with the doctor.
• A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor.
• If you are 65 or older, use this medicine (fluconazole tablets) with care. You could have more side effects.
• If you are able to get pregnant, talk with your doctor. You may need to use birth control to prevent pregnancy while taking this medicine (fluconazole tablets) and for some time after your last dose.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this medicine (fluconazole tablets), call your doctor right away.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Fluconazole Tablets) best taken?

Use this medicine (fluconazole tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with or without food.
• Keep taking this medicine (fluconazole tablets) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
• A type of abnormal heartbeat (prolonged QT interval) has happened with this medicine (fluconazole tablets). Sometimes, this has led to another type of unsafe abnormal heartbeat (torsades de pointes). Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out.

What are some other side effects of Fluconazole Tablets?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache.
• Stomach pain or diarrhea.
• Upset stomach or throwing up.
• Dizziness.
• Change in taste.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Fluconazole Tablets?

• Store at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine (fluconazole tablets), please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Frequently asked questions

• Fluconazole – How long does it take to work?
• Does fluconazole flush out yeast/discharge?
• Fluconazole – can you drink alcohol while using one dose of 150mg one time?
• What is the dose of fluconazole for tinea? Is it is indicated for tinea infections?
• I am having a reaction after taking fluconazole and would like to know if this is normal?

More about fluconazole

• Check interactions
• Compare alternatives
• Pricing & coupons
• Reviews (509)
• Drug images
• Side effects
• Dosage information
• Patient tips

Patient resources

• Drug Information
• Fluconazole (Advanced Reading)
• Fluconazole Intravenous (Advanced Reading)
• Fluconazole Injection Solution
• Fluconazole Oral Suspension
• During pregnancy
• Support group
• Breastfeeding
• En español

Other brands

Professional resources

• Prescribing Information
• Drug class: azole antifungals

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Fluconazole

Generic name: fluconazole (oral/injection) [ floo-KOE-na-zole ]
Brand name: Diflucan
Dosage forms: intravenous solution (100 mg/50 mL-NaCl 0.9%; 200 mg/100 mL-0.9%; 400 mg/200 mL-0.9%); oral powder for reconstitution (10 mg/mL; 40 mg/mL); oral tablet (100 mg; 150 mg; 200 mg; 50 mg)
Drug class: Azole antifungals

Medically reviewed by Drugs.com on Jan 25, 2023. Written by Cerner Multum.

What is fluconazole?

Fluconazole is an antifungal medicine that is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood.

Fluconazole is also used to prevent fungal infection in people who have a weak immune system caused by cancer treatment, bone marrow transplant, or diseases such as AIDS.

Fluconazole is also used to treat a certain type of meningitis in people with HIV or AIDS.

Fluconazole may also be used for purposes not listed in this medication guide.

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

You should not use fluconazole if you are allergic to it.

Some drugs should not be used with fluconazole. Your treatment plan may change if you also use:

• lemborexant, abrocitinib, theophylline, fentanyl, alfentanil, methadone, pimozide, tofacitinib, tolvaptan, or a vitamin A supplement;
• an antibiotic, antifungal, or antiviral medicine;
• a blood thinner;
• cancer medicine;
• cholesterol medication;
• oral diabetes medicine;
• heart or blood pressure medication;
• medicine for malaria or tuberculosis;
• medicine to prevent organ transplant rejection;
• medicine to treat depression or mental illness;
• an NSAID (nonsteroidal anti-inflammatory drug);
• seizure medicine; or
• steroid medicine.

Tell your doctor if you have ever had:

• liver or kidney disease;
• low levels of potassium in your blood;
• heart problems; or
• if you are allergic to other antifungal medicine (such as ketoconazole, itraconazole, miconazole, posaconazole, voriconazole, and others).

The liquid form of fluconazole contains sucrose. Talk to your doctor before taking this form of fluconazole if you have a problem digesting sugars or milk.

May harm an unborn baby. Use effective birth control while using fluconazole and for at least 1 week after your last dose. Tell your doctor if you become pregnant.

Ask a doctor if it is safe to breastfeed while using fluconazole.

How is fluconazole given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your dose will depend on the infection you are treating. Vaginal infections are often treated with only one pill. For other infections, your first dose may be a double dose. Carefully follow your doctor’s instructions.

Fluconazole oral is taken by mouth. Fluconazole injection is given as an infusion into a vein.

You may take fluconazole oral with or without food.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Fluconazole injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Use fluconazole for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Fluconazole will not treat a viral infection such as the flu or a common cold.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat. Do not freeze.

You may store the oral suspension between 86 F (30 C) and 41 F (5 C), but do not allow it to freeze. Throw away any leftover liquid that is more than 2 weeks old.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion or unusual thoughts or behavior.

What should I avoid while using fluconazole?

Avoid driving or hazardous activity until you know how fluconazole will affect you. Your reactions could be impaired.

Fluconazole side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Fluconazole may cause serious side effects. Call your doctor at once if you have:

• fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
• seizure (convulsions);
• skin rash or skin lesions;
• decreased adrenal gland hormones–nausea, vomiting, stomach pain, loss of appetite, feeling tired or light-headed, muscle or joint pain, skin discoloration, craving salty foods; or
• liver problems–loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of fluconazole may include:

• nausea, stomach pain, diarrhea, upset stomach;
• headache;
• dizziness; or
• changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fluconazole?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Fluconazole can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect fluconazole, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Popular FAQ

Fluconazole inhibits the growth of the yeast Candida albicans, which is most commonly responsible for Vaginal yeast infections. This allows our body’s defenses to eliminate the fungus and resolve the discharge. It does this by blocking the effects of an enzyme called lanosterol 14-α-demethylase which is responsible for the formation of ergosterol, an important component of the yeast’s cell wall. This causes toxic substances to build up inside the yeast, reducing its ability to build up and cause an infection. Continue reading

More FAQ

• Fluconazole – How long does it take to work?
• Fluconazole – can you drink alcohol while using one dose of 150mg one time?
• What is the dose of fluconazole for tinea? Is it is indicated for tinea infections?
• I am having a reaction after taking fluconazole and would like to know if this is normal?

More about fluconazole

• Check interactions
• Compare alternatives
• Pricing & coupons
• Reviews (509)
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: azole antifungals
• Breastfeeding
• En español