The FANCG gene is one of the many genes that play a crucial role in Fanconi anemia, a rare genetic disorder that affects the body’s ability to repair damaged DNA. Variants in the FANCG gene can cause deficiencies in certain proteins that are essential for DNA repair, leading to the development of various health conditions.
Scientific information about the FANCG gene and its related proteins can be found in various databases and resources. One such resource is the Online Mendelian Inheritance in Man (OMIM) catalog, which provides comprehensive information about genetic diseases and their associated genes. The FANCG gene is listed in the OMIM catalog along with references to relevant articles and scientific publications from PubMed.
In addition to genetic testing for variants in the FANCG gene, other genes associated with Fanconi anemia can also be tested. These genes, known as complementation group genes, work together to maintain the normal functioning of the Fanconi anemia pathway. Testing for variants in these genes can provide further insights into the genetic basis of the disease.
For individuals suspected to have Fanconi anemia, blood tests can be conducted to assess the levels of proteins related to the FANCG gene. Physical examinations and additional testing may also be required to confirm the diagnosis and determine the specific genetic changes involved.
Understanding the role of the FANCG gene and other related genes in Fanconi anemia is critical for the development of targeted therapies and improved management of this rare genetic disorder. Ongoing research and collaborations among scientists and healthcare professionals are vital in unraveling the complexities of Fanconi anemia and finding effective treatments for affected individuals.
Health Conditions Related to Genetic Changes
Many health conditions are known to be related to genetic changes in various genes. This scientific information is collected from different sources, such as scientific articles, databases like PubMed and OMIM, and other resources.
One group of genes that has been extensively studied in relation to health conditions is the FANCG gene. The FANCG gene is involved in DNA repair and is a part of the Fanconi Anemia pathway. Fanconi Anemia is a rare genetic disorder that primarily affects the bone marrow and leads to a decrease in the production of all types of blood cells.
Genetic changes in the FANCG gene, as well as in other genes in the Fanconi Anemia pathway, can result in various health conditions and diseases. Some of the conditions associated with these genetic changes include Fanconi Anemia, certain types of cancer, and other physical and developmental abnormalities.
The Fanconi Anemia Research Fund maintains a comprehensive registry of individuals with Fanconi Anemia and related disorders. This registry provides information on the specific genetic changes and clinical features observed in these individuals. Testing for variants in the FANCG gene and other Fanconi Anemia-related genes is available.
Additional information about specific genetic changes and associated health conditions can be found in scientific articles, databases, and resources like PubMed, OMIM, and the Fanconi Anemia Mutation Database. These resources provide a wealth of information on the genetic basis of various health conditions.
It is important to note that the names of genes and proteins mentioned in this article are based on the scientific literature and may differ from the names commonly used in other contexts.
In conclusion, genetic changes in the FANCG gene and other genes involved in the Fanconi Anemia pathway can lead to a variety of health conditions and diseases. The scientific community continues to investigate the role of these genes and their associated proteins in maintaining health and preventing disease.
Fanconi anemia
Fanconi anemia is a rare genetic disorder that affects the body’s ability to repair damaged DNA. It is part of a group of genetic diseases known as the Fanconi anemia complementation group.
Individuals with Fanconi anemia may experience physical abnormalities, bone marrow failure, and an increased risk of certain types of cancer. The disease is caused by changes in certain genes, including the FANCG gene and other genes involved in DNA repair.
Diagnosis of Fanconi anemia can be made through genetic testing, which can identify variants in the FANCG gene and other related genes. Additional testing, such as blood tests and physical examinations, may also be performed to confirm the diagnosis.
The Fanconi Anemia Registry is a resource that collects information from individuals with Fanconi anemia and their families. The registry helps researchers and healthcare professionals better understand the disease and develop effective treatments.
Scientific articles and references on Fanconi anemia can be found in databases such as PubMed and OMIM. These resources provide information on the disease, its genetic basis, and potential treatment options.
Research on Fanconi anemia has led to the identification of core genes and proteins involved in DNA repair. Understanding these genes and their role in the disease can help in the development of targeted therapies for Fanconi anemia and other related conditions.
Overall, Fanconi anemia is a rare genetic disorder that affects the body’s ability to repair DNA damage. Advances in genetic testing, research, and resources have provided valuable information for individuals with Fanconi anemia and their healthcare providers.
Other Names for This Gene
The FANCG gene, also known by several other names, is a gene that plays a role in certain genetic diseases related to Fanconi anemia. The gene is also known as:
- Fanconi anemia, complementation group G gene
- Fanconi anemia, complementation group G
- FA-G
- FACG
- Fang
These names may be used interchangeably in scientific literature, databases, and other resources for genetic testing and information on Fanconi anemia and related conditions.
Additional names and variant names may also be listed in OMIM (Online Mendelian Inheritance in Man), PubMed (a database of scientific articles), and other genetic databases and resources.
For individuals looking for more information on Fanconi anemia, genetic testing, and related conditions, it is recommended to consult these resources along with healthcare professionals and experts in the field.
Additional Information Resources
-
Genes:
The FANCG gene is one of the many genes related to Fanconi anemia. Changes in this gene can cause the disorder or lead to changes in other genes involved in DNA repair.
-
Scientific Articles:
PubMed provides a catalog of scientific articles related to the FANCG gene and its variant names, which you can find here.
-
Genetic Testing:
For testing of genetic conditions related to the FANCG gene, you can refer to the testing resources listed in the genetic testing registry. These tests can help diagnose certain individuals with Fanconi anemia or other related conditions.
-
Additional Resources:
For more information on the FANCG gene, you can explore the following databases and resources:
- OMIM: A comprehensive catalog of human genes and genetic disorders.
- Gene: A database providing information on genes and their functions.
- FANC Database: A registry of Fanconi anemia complementation group genes.
- Fanconi Anemia Research Fund: An organization dedicated to advancing research and support for individuals with Fanconi anemia.
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry (GTR) is a database that provides information on genetic tests for a variety of conditions, including Fanconi anemia. This registry is a valuable resource for individuals seeking information about the genetic testing options available to them.
Fanconi anemia is a rare genetic disorder that affects the body’s ability to repair damaged DNA. It is characterized by a variety of physical abnormalities, bone marrow failure, and an increased risk of certain types of cancer.
In the GTR, tests related to the FANCG gene and other genes associated with Fanconi anemia are listed. These tests detect changes or variants in these genes that may be associated with the development of the condition.
This registry provides scientific and medical professionals with easy access to information on available tests, including their names, associated genes, and references to scientific articles and databases. It also offers additional resources, such as links to OMIM and PubMed, for those seeking more in-depth information.
The GTR categorizes tests based on their purpose. For Fanconi anemia, these include diagnostic tests, predictive tests, carrier tests, and prenatal tests. Diagnostic tests are used to confirm a diagnosis in individuals who already display symptoms of Fanconi anemia. Predictive tests are used to identify individuals who have an increased risk of developing the condition. Carrier tests are used to determine if individuals carry a mutation in the FANCG gene or other genes associated with Fanconi anemia. Prenatal tests are used to detect the presence of these mutations in unborn babies.
The GTR also provides information on the core conditions associated with Fanconi anemia, such as bone marrow failure, physical abnormalities, and an increased risk of cancer. It offers comprehensive information on these conditions and the genetic factors that contribute to their development.
| Test Name | Gene(s) | Test Purpose |
|---|---|---|
| Diagnostic Test | FANCG, other related genes | Confirm diagnosis in individuals with symptoms |
| Predictive Test | FANCG, other related genes | Identify individuals at increased risk |
| Carrier Test | FANCG, other related genes | Determine carrier status |
| Prenatal Test | FANCG, other related genes | Detect mutations in unborn babies |
The GTR is a valuable tool for individuals and healthcare providers who are interested in genetic testing for Fanconi anemia. It provides a comprehensive list of available tests, along with information on the genes involved and the purposes of each test. By using this resource, individuals can make informed decisions about their healthcare and gain a better understanding of their genetic risk for Fanconi anemia.
Scientific Articles on PubMed
The FANCG gene, also known as the FANCC variant, is associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, physical abnormalities, and an increased risk of developing certain types of cancer.
To learn more about the FANCG gene and its role in Fanconi anemia, you can refer to scientific articles available on PubMed. PubMed is a registry of references and articles related to scientific research in various fields of study, including genetics. It provides a vast collection of resources, including articles, reviews, and core databases, which can be accessed by individuals interested in learning more about specific genes and genetic diseases.
By searching for “FANCG gene” on PubMed, you can find a catalog of scientific articles that discuss this gene in relation to Fanconi anemia and other related diseases. These articles provide valuable information on the genetic changes and proteins involved in the repair of DNA damage, complementation testing, and testing for Fanconi anemia in individuals.
Some of the key resources available on PubMed include articles from the Journal of Clinical Investigation, the American Journal of Human Genetics, and the Journal of Biological Chemistry. These articles provide detailed information on the role of the FANCG gene in Fanconi anemia and its potential implications for cancer testing and other health conditions.
In addition to PubMed, you can also access information on the FANCG gene and related diseases through other databases, such as OMIM (Online Mendelian Inheritance in Man). OMIM provides detailed descriptions of genes and their associated diseases, including Fanconi anemia, and can be a valuable resource for individuals seeking more information on the genetic basis of these conditions.
Overall, the scientific articles listed on PubMed and other resources provide a wealth of information on the FANCG gene, Fanconi anemia, and related genetic diseases. By delving into these scientific articles, individuals can gain a deeper understanding of the genetic basis of Fanconi anemia and the potential implications for diagnosis, treatment, and prevention.
Catalog of Genes and Diseases from OMIM
The FANCG gene is a member of the Fanconi anemia complementation group. It is involved in the repair of DNA damage and plays a crucial role in maintaining the stability of the genome. Mutations in the FANCG gene can lead to Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, birth defects, and an increased risk of cancer.
This catalog provides information on genes and diseases related to the FANCG gene and Fanconi anemia. It includes a comprehensive list of genes associated with Fanconi anemia, along with information on their functions and the physical changes observed in affected individuals. The catalog also includes references to scientific articles and resources for further reading.
Genes Associated with Fanconi Anemia
The core OMIM gene for Fanconi anemia is FANCA. However, mutations in several other genes, including FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCO, FANCP, FANCQ, FANCR, FANCS, FANCT, FANCU, FANCV, and FANCW, have also been identified in individuals with Fanconi anemia.
These genes play important roles in DNA repair and the maintenance of genome stability. Variants in these genes can disrupt the normal functioning of the Fanconi anemia pathway and result in the characteristic features of the disorder.
Resources and References
For more information on the FANCG gene, Fanconi anemia, and related genes, the following resources may be helpful:
- OMIM: The Online Mendelian Inheritance in Man (OMIM) database provides detailed information on genes and genetic conditions. The entry for the FANCG gene can be found at OMIM entry: 227645.
- PubMed: The PubMed database contains a vast collection of scientific articles on various topics, including Fanconi anemia and related genes. Searching for keywords such as “FANCG gene” or “Fanconi anemia” will yield a wealth of research papers and reviews.
- Fanconi Anemia Mutation Database: This database provides a comprehensive collection of genetic changes (mutations) in Fanconi anemia-associated genes. It can be accessed at https://www2.rockefeller.edu/fanconi/.
- Other Databases: In addition to OMIM and PubMed, there are other databases and resources available for genetic testing and information on Fanconi anemia and related conditions. These include the Human Gene Mutation Database, ClinVar, and the Genetic Testing Registry, among others.
By exploring these resources, individuals can access valuable information on the FANCG gene, Fanconi anemia, and other related genes and diseases. This knowledge can aid in understanding the underlying genetic basis of the condition and contribute to advancements in diagnosis, treatment, and overall management of Fanconi anemia and associated health conditions.
Gene and Variant Databases
The FANCG gene, along with other core genes of the Fanconi Anemia (FA) pathway, is involved in the repair of DNA interstrand crosslinks (ICLs). Variants in the FANCG gene can lead to a loss of function, resulting in Fanconi Anemia.
There are several databases that catalog the gene and variant changes associated with Fanconi Anemia and other related genetic conditions. These databases provide additional information on the genes and proteins involved in the Fanconi Anemia pathway, as well as the specific variant changes that have been identified in individuals with Fanconi Anemia.
One such database is the FANCG variant catalog, which lists the variant changes found in the FANCG gene in individuals with Fanconi Anemia. This database provides information on the specific variant changes, their impact on the FANCG protein, and the clinical features associated with each variant.
Additionally, there are other databases that provide resources for variant testing and genetic testing for Fanconi Anemia. These databases include online resources such as OMIM, which provides information on genetic conditions and genes, as well as PubMed, which provides access to scientific articles and references on Fanconi Anemia and related conditions.
For individuals with Fanconi Anemia or other related genetic conditions, these databases can provide valuable information on the specific variant changes in their genes, as well as additional resources for testing and management of their condition.
In addition to databases specific to Fanconi Anemia, there are also databases that provide information on other genetic conditions and complementation groups. These databases can provide information on the genes involved in these conditions, variant changes that have been identified, and additional resources for testing and management of these conditions.
In summary, gene and variant databases play a crucial role in providing access to information on the genes and proteins involved in Fanconi Anemia and related conditions. These databases provide valuable resources for variant testing, genetic testing, and management of these conditions. Individuals with Fanconi Anemia can benefit from accessing these databases to gain a better understanding of their condition and explore potential treatment options.
References
- Other resources and databases related to FANCG gene complementation:
- Pubmed – a scientific database that contains articles on FANCG gene
- Certain genes related to FANCG: FANCA, FANCC, FANCE, FANCF, FANCL, FANCM
- Core repair genes: FANCB, FANCD2, FANCD1
- The Cancer Gene Census – a registry of genes that are thought to play a role in cancer
- OMIM – Online Mendelian Inheritance in Man, a catalog of human genes and genetic disorders
- Tests for FANCG gene variant proteins:
- Physical testing of individuals with Fanconi anemia
- Scientific articles listed on Pubmed related to FANCG
- Additional information and resources on FANCG gene and related diseases and conditions can be found in the following references:
- Fanconi Anemia – a health information resource on Fanconi anemia
- The Fanconi Anemia Research Fund – a non-profit organization dedicated to funding research on Fanconi anemia
- The Genetic Testing Registry – a comprehensive resource on genetic testing for various conditions
- The Human Gene Mutation Database – a database of gene mutations associated with human diseases