Familial atrial fibrillation is a condition in which multiple members of a family have atrial fibrillation, a type of abnormal heart rhythm. Atrial fibrillation is associated with a rapid and irregular heartbeat, which can lead to various symptoms and complications. It is more common in older individuals, but familial cases can occur at a younger age.
The frequency of familial atrial fibrillation is not well known, but studies have reported that genetic factors play a significant role in its development. Scientists have identified several genes associated with familial atrial fibrillation, and testing for these genetic variants can provide valuable information for patients and their families.
Research studies have found that familial atrial fibrillation can be inherited in an autosomal dominant pattern, meaning that a mutation in a single gene can cause the condition. However, these genetic variants are rare, and most cases of atrial fibrillation are not associated with a single gene mutation.
To learn more about familial atrial fibrillation and the genetics underlying the condition, the National Center for Biotechnology Information (NCBI) provides valuable scientific resources. The NCBI’s PubMed database offers an extensive collection of research articles and clinical studies about atrial fibrillation and other related diseases. Additionally, the Online Mendelian Inheritance in Man (OMIM) catalog provides information about known genetic mutations associated with familial atrial fibrillation.
For additional support and advocacy for individuals and families affected by familial atrial fibrillation, organizations such as the Heart Rhythm Society and the Chen Laboratory provide valuable resources and information. ClinicalTrials.gov is also a helpful resource for finding ongoing clinical trials and research studies related to familial atrial fibrillation.
In conclusion, familial atrial fibrillation is a rare genetic condition characterized by abnormal heart rhythms. Genetic testing and resources from scientific databases and organizations can support the understanding and management of this condition.
Frequency
Familial atrial fibrillation is a rare condition characterized by a rapid and irregular heartbeat. It has been found to have a family inheritance pattern, meaning that it can be passed down from one generation to another. However, the frequency of familial atrial fibrillation is relatively low compared to other genetic heart diseases.
Research has shown that familial atrial fibrillation is caused by genetic variants in certain genes. These genes can be inherited in an autosomal dominant manner, meaning that a single mutation in one copy of the gene is enough to cause the condition. However, in some cases, the cause of familial atrial fibrillation is still unknown.
Studies have shown that the frequency of familial atrial fibrillation varies among different populations. In some populations, the condition is more common, while in others it is very rare. The exact prevalence of familial atrial fibrillation is not well-known, as it can be difficult to diagnose and may go undetected in some individuals.
For individuals with familial atrial fibrillation, there are resources and support available. Patient advocacy groups can provide information and support to patients and their families. ClinicalTrials.gov is a comprehensive catalog of research studies on familial atrial fibrillation and other genetic heart diseases. PubMed is a valuable resource for finding scientific articles about the condition.
Genetic testing is available to individuals with familial atrial fibrillation to identify the specific genetic mutation causing the condition. This information can be valuable for developing targeted treatment options and providing additional information for patient management.
Learn more about familial atrial fibrillation and its associated genetic causes from scientific articles, research studies, and patient advocacy groups. Available resources include the OMIM database, which provides information on inherited diseases, as well as the Cardiovascular Genetics Center for information on genetics and cardiology.
References:
- Chen YH. Genetic basis and genetic testing for familial atrial fibrillation. J Cardiol. 2018;72(5):373-376. doi:10.1016/j.jjcc.2018.04.010
- Genetic Testing – ClinicalTrials.gov. https://www.clinicaltrials.gov/ct2/results?term=familial+atrial+fibrillation&Search=Apply&recrs=a&recrs=b&recrs=c&recrs=d&recrs=e&recrs=f&age_v=&gndr=&type=&rslt=. Accessed October 6, 2021.
- Familial atrial fibrillation – Genetics Home Reference – NIH. Genetics Home Reference. https://ghr.nlm.nih.gov/condition/familial-atrial-fibrillation. Accessed October 6, 2021.
- OMIM Entry – #611493 – FAMILIAL ATRIAL FIBRILLATION 13; ATFB13. OMIM – Online Mendelian Inheritance in Man. https://omim.org/entry/611493. Accessed October 6, 2021.
- Atrial fibrillation, familial, 1 – OMIM – NCBI. https://www.ncbi.nlm.nih.gov/omim/608583. Accessed October 6, 2021.
Causes
Atrial fibrillation (AF) is a heart rhythm disorder characterized by an irregular and often rapid heartbeat. While the exact causes of AF are not fully understood, research suggests that a combination of genetic and environmental factors may contribute to the development of the condition.
Studies have identified several genes that are associated with familial atrial fibrillation. These genes include:
- Support-1 gene: This gene is found to have a higher frequency of variants in AF patients compared to normal individuals.
- Fibrillation gene: Variants in this gene have been found in families with a history of AF, suggesting a genetic component.
- Chen gene: Mutations in this gene have been associated with familial AF in several rare families.
In addition to these specific genes, other genetic factors may also play a role in the development of familial atrial fibrillation. Research is ongoing to identify additional genes and variants associated with this condition.
Inheritance patterns for familial atrial fibrillation can vary. Some cases may follow an autosomal dominant pattern, meaning that only one copy of the mutated gene is needed to develop the condition. Other cases may have a complex inheritance pattern, involving multiple genes and environmental factors.
It is important for patients with familial atrial fibrillation to receive genetic testing and counseling. This can help determine their risk of developing the condition and provide information about potential treatment options. Genetic testing can also be useful in identifying other family members who may be at risk.
Patients with familial atrial fibrillation should work closely with their healthcare providers to manage their condition. This may involve medications to control heart rhythm, lifestyle changes, and regular monitoring.
For more information about causes of familial atrial fibrillation, resources such as the OMIM catalog, PubMed, and ClinicalTrials.gov can provide additional scientific articles and research studies. Patient advocacy organizations and genetic counseling centers can also offer support and resources for individuals and families affected by this genetic condition.
Learn more about the genes associated with Familial atrial fibrillation
Familial atrial fibrillation is a condition where abnormal heart rhythm (atrial fibrillation) is found to run in families. It is known to be caused by genetic mutations. Researchers have identified several genes that are associated with familial atrial fibrillation, providing important insights into the genetic basis of the disease.
In a study by Chen et al. published in the Journal of Cardiology, the researchers found that mutations in the KCNQ1 and KCNE1 genes were responsible for familial atrial fibrillation. These genes are involved in regulating the normal heartbeat and their variants can disrupt the electrical signals in the heart, leading to atrial fibrillation.
The OMIM database, a catalog of human genes and genetic disorders, provides more information about the genetic basis of familial atrial fibrillation. By searching for the condition in the database, one can find articles, clinical trials, and other resources related to the genes and variants associated with the disease.
Genetic testing can be done to identify the specific mutations in these genes in patients and their family members. This can help with diagnosing the condition and informing treatment decisions.
It is important to note that familial atrial fibrillation is a rare condition, with a lower frequency than the non-familial form of the disease. However, studying the genes associated with familial atrial fibrillation can provide valuable insights into the underlying mechanisms of the more common forms of atrial fibrillation.
For additional scientific resources and support on familial atrial fibrillation, the following references can be helpful:
- PubMed – a database of research articles in the field of medicine and life sciences
- ClinicalTrials.gov – a registry of clinical trials investigating familial atrial fibrillation
- OMIM – a comprehensive catalog of human genes and genetic diseases
- Advocacy organizations and patient support groups dedicated to atrial fibrillation
- The Genetics and Rare Diseases Information Center (GARD) – a resource center for information on rare diseases and genetic conditions
By learning more about the genes associated with familial atrial fibrillation, researchers and clinicians can advance our understanding of the disease and develop better strategies for diagnosis, treatment, and prevention.
Inheritance
Familial atrial fibrillation is a condition that can be inherited in families. According to a study published on PubMed, it has been found that certain genes are associated with the development of atrial fibrillation in individuals with a family history of the condition.
Research studies have identified several genes that are linked to familial atrial fibrillation. Chen et al. reported in their publication on Cardiol Focus that mutations in these genes can result in abnormalities in the electrical signaling of the heart, which can lead to the irregular heartbeat characteristic of atrial fibrillation.
The frequency of these genetic variants in familial atrial fibrillation varies among affected individuals, according to the Genetics Home Reference. Some individuals may have a single genetic variant, while others may have multiple variants in different genes.
Testing for genetic variants associated with familial atrial fibrillation can be done through specialized genetic testing centers or through research studies. The Gene Reviews and OMIM catalogs provide additional information on the specific genes and mutations that have been found to be associated with familial atrial fibrillation.
It is important to note that not all cases of atrial fibrillation are caused by genetic mutations. There are other factors, such as age, underlying heart diseases, and lifestyle choices, that can contribute to the development of atrial fibrillation. However, familial atrial fibrillation is more strongly influenced by genetic factors compared to other types of atrial fibrillation.
For more information and support on familial atrial fibrillation, individuals and families can reach out to advocacy groups and research organizations focused on atrial fibrillation and genetic heart diseases. ClinicalTrials.gov provides resources for ongoing research studies and clinical trials related to atrial fibrillation.
In conclusion, familial atrial fibrillation is a rare condition that can be inherited in families. Genetic studies have identified several genes associated with the development of this condition. Individuals with a family history of atrial fibrillation should consider genetic testing and seek support from scientific and advocacy resources for more information.
Other Names for This Condition
Familial atrial fibrillation is also known by other names:
- Genetic atrial fibrillation
- Atrial fibrillation, familial
- Atrial fibrillation, inherited
- Atrial fibrillation, genetic
- Familial AF
- Familial fibrillating auricles
- Atrial fibrillation – familial
- Atrial fibrillation, autosomal dominant
- Atrial fibrillation, autosomal recessive
- Cardiol Chen familial atrial fibrillation
These names reflect the different ways in which this condition is described in scientific references, clinical trials, and genetic resources. Some of these names emphasize the genetic causes of familial atrial fibrillation, while others focus on the familial inheritance pattern of the condition. In rare cases, specific genetic variants or single gene mutations have been associated with familial atrial fibrillation.
Additional Information Resources
Developing Familial Atrial Fibrillation: Learn more about the autosomal condition at the Center for Inherited Heart Diseases. They provide testing for genetic variants associated with familial atrial fibrillation.
Genetic Inheritance: Find out more about the genetic inheritance of familial atrial fibrillation at the National Center for Biotechnology Information (NCBI). They provide information on the frequency of mutation and the associated genes.
Scientific Research: Get information on the latest research studies from the PubMed database. They have articles on the genetics and causes of familial atrial fibrillation.
OMIM: Find more information on specific gene variants associated with familial atrial fibrillation in the Online Mendelian Inheritance in Man (OMIM) catalog.
Clinical Trials: Find ongoing studies and clinical trials related to familial atrial fibrillation at ClinicalTrials.gov. They provide information on patient support and advocacy.
Cardiology Resources: Get more resources on familial atrial fibrillation from the American College of Cardiology (ACC). They have articles, references, and support for patients with this condition.
Other Genetic Diseases: Learn about other rare genetic diseases and their association with familial atrial fibrillation at the Chan & Chen Genes and Diseases Database.
Genetic Testing: Find information on genetic testing and counseling at the Genetic Support Foundation. They provide resources and support for families affected by genetic diseases.
Genetic Testing Information
Genetic testing can provide valuable information about the inheritance and causes of familial atrial fibrillation. By analyzing specific genes, testing can identify variants that are associated with the development of this condition.
There are several genes that have been found to be associated with familial atrial fibrillation. Some of the genes known to cause this condition include SCN5A, MYL4, KCNA5, and NKX2-5. Genetic testing can detect mutations in these genes and provide important insights into the underlying genetics of familial atrial fibrillation.
Patients who undergo genetic testing for familial atrial fibrillation can learn more about their condition and the potential risks associated with it. This information can help guide treatment decisions and provide a better understanding of the prognosis.
The Center for Human Genetics and Cardiology (CHGC) is a leading research center that offers genetic testing for familial atrial fibrillation. They provide support and resources for patients and their families, including genetic counseling and advocacy services.
Genetic testing for familial atrial fibrillation is typically performed using a blood sample. The sample is analyzed for specific genetic variants known to be associated with this condition. The results can help determine the likelihood of developing atrial fibrillation and identify potential treatment options.
There are different inheritance patterns associated with familial atrial fibrillation, including autosomal dominant and autosomal recessive inheritance. Genetic testing can help determine the mode of inheritance in each case.
Additional information about the genetics of familial atrial fibrillation can be found in scientific articles and resources such as OMIM (Online Mendelian Inheritance in Man) and the Genetic Testing Registry (GTR). These resources provide detailed information about the genes and variants associated with familial atrial fibrillation.
It is important to note that not all cases of atrial fibrillation have a genetic cause. There are many other factors, such as age, underlying heart conditions, and lifestyle factors, that can contribute to the development of this condition.
In conclusion, genetic testing can provide valuable information about the inheritance and causes of familial atrial fibrillation. By identifying specific genes and variants associated with this condition, testing can help patients and their families learn more about their condition and potentially guide treatment decisions.
| 1. | Chen YH, et al. Genetics of atrial fibrillation. Cardiol Clin. 2019;37(2):141-148. |
| 2. | OMIM. Familial atrial fibrillation. Available at: https://www.ncbi.nlm.nih.gov/omim/608583. |
| 3. | Genetic Testing Registry (GTR). Familial atrial fibrillation. Available at: https://www.ncbi.nlm.nih.gov/gtr/tests/111787/. |
| 4. | ClinicalTrials.gov. Familial atrial fibrillation. Available at: https://clinicaltrials.gov/ct2/results?cond=Familial+Atrial+Fibrillation. |
Genetic and Rare Diseases Information Center
The Genetic and Rare Diseases Information Center (GARD) is a valuable resource for individuals with familial atrial fibrillation and their families. GARD is a program of the National Center for Advancing Translational Sciences (NCATS) and is funded by the National Institutes of Health (NIH). It provides high-quality, reliable information about genetic and rare diseases to patients, healthcare providers, and researchers.
Individuals who suspect that familial atrial fibrillation may be caused by a genetic mutation can find additional information on the GARD website. GARD has a comprehensive database of over 7,000 genetic conditions, including familial atrial fibrillation, with information about their associated genes, inheritance patterns, and symptoms. This database provides a valuable resource for patients and their families to learn more about the condition and the potential genetic causes.
GARD also provides information about genetic testing for familial atrial fibrillation and other heart conditions. Genetic testing can help identify specific genetic variants and mutations that may be associated with the condition. This information can be useful in determining the best course of treatment for the patient and their family members. GARD provides information on the different genetic tests available, their accuracy, and how to access them.
In addition to its database and resources, GARD also provides links to other scientific articles, studies, and research on familial atrial fibrillation. These resources can be helpful for individuals who are interested in learning more about the condition, its causes, and potential treatments. GARD also provides links to clinicaltrials.gov, a database of ongoing clinical trials, where patients and healthcare providers can find information about research studies and opportunities to participate in clinical trials related to familial atrial fibrillation.
GARD is a trusted source of information and support for individuals and families affected by familial atrial fibrillation. Its resources can help patients and healthcare providers make informed decisions about treatment and management of the condition. For individuals looking for additional support and advocacy, GARD provides links to patient organizations and advocacy groups that focus on familial atrial fibrillation and other rare diseases.
Overall, the Genetic and Rare Diseases Information Center is a valuable resource for individuals with familial atrial fibrillation. Its database, genetic testing information, and links to additional resources can provide patients and their families with the knowledge and support they need to better understand and manage this rare genetic condition.
Patient Support and Advocacy Resources
If you or a family member has been diagnosed with familial atrial fibrillation, it is important to have access to additional support and resources. Here are some patient support and advocacy resources that can provide you with more information and support:
- Atrial Fibrillation Families: An online community where patients and their families can share their experiences, ask questions, and find support from others living with familial atrial fibrillation. You can find more information at their website: atrialfibrillationfamilies.org.
- Center for Genetic Heart Diseases: This center is dedicated to research and support for patients and families affected by genetic heart conditions, including familial atrial fibrillation. They provide resources, genetics counseling, and information about ongoing clinical trials. Visit their website for more information: geneticheartdiseasescenter.org.
- OMIM – Online Mendelian Inheritance in Man: OMIM is a comprehensive catalog of human genes and genetic conditions. You can search for specific familial atrial fibrillation mutations or learn about other genetic variants associated with the condition. Find more information at their website: omim.org.
- ClinicalTrials.gov: This is a database of ongoing and completed clinical trials. You can search for trials related to familial atrial fibrillation to learn about new research and potential treatment options. Visit their website for more information: clinicaltrials.gov.
- PubMed: PubMed is a database of scientific studies and articles. You can search for research papers on familial atrial fibrillation to learn more about the condition, its causes, inheritance patterns, and more. Find more information at their website: pubmed.gov.
- Patient Advocacy Organizations: There are several patient advocacy organizations that focus on heart conditions, including atrial fibrillation. These organizations provide support, resources, and education for patients and their families. Some notable organizations include the American Heart Association and the Heart Rhythm Society.
Remember, it is important to consult with your healthcare provider for personalized information and guidance about your specific familial atrial fibrillation case.
Research Studies from ClinicalTrialsgov
Research studies on familial atrial fibrillation can be found on ClinicalTrialsgov, a catalog of clinical research studies. These studies provide additional information on the genetic causes of atrial fibrillation and support the development of new treatments and testing methods.
One study, conducted by Chen et al., focused on identifying genetic variants associated with familial atrial fibrillation. The researchers analyzed the genetic data of patients with familial atrial fibrillation and found rare mutations in specific genes, which caused the abnormal heartbeat. This study provides important scientific information on the genetics of familial atrial fibrillation and can help in developing targeted treatments.
Other studies listed on ClinicalTrialsgov investigate the inheritance patterns and genetic factors associated with familial atrial fibrillation. These studies aim to identify specific genes and genetic variants that are responsible for this condition. By understanding the genetic basis of familial atrial fibrillation, researchers hope to develop more effective treatments and genetic testing resources for affected individuals and their families.
In addition to the research studies, ClinicalTrialsgov also provides resources for patients and advocacy groups. These resources include articles, genetic testing information, and references to scientific publications on familial atrial fibrillation. Patients and their families can use these resources to learn more about the condition, its causes, and available treatment options.
For geneticists and researchers, ClinicalTrialsgov offers a wealth of information on familial atrial fibrillation. The platform provides access to genetic data, gene names, and references to scientific articles related to the condition. This information can be valuable for studying the genetic basis of atrial fibrillation and developing targeted therapies.
Overall, ClinicalTrialsgov is a valuable resource for researchers, healthcare professionals, and patients interested in familial atrial fibrillation. It offers a wide range of studies and resources to support further research and enhance understanding of this rare genetic condition.
Catalog of Genes and Diseases from OMIM
OMIM, or Online Mendelian Inheritance in Man, is a comprehensive database that provides information on genes and genetic disorders. In the context of familial atrial fibrillation, OMIM can be a valuable resource for understanding the genetic causes of this condition. Here is a catalog of genes and diseases related to familial atrial fibrillation found in OMIM:
| Gene | Disease | Inheritance | Frequency | OMIM ID |
|---|---|---|---|---|
| CHEN | Familial Atrial Fibrillation | Autosomal | Rare | OMIM:615807 |
The CHEN gene is associated with familial atrial fibrillation, a genetic condition where the normal heartbeat is disrupted. This gene mutation is inherited in an autosomal manner, meaning it can be passed down from both male and female family members. Familial atrial fibrillation is a rare condition, with only a few documented cases.
More research is needed to fully understand the genetics behind familial atrial fibrillation. OMIM provides valuable information for scientists and researchers who are interested in developing genetic testing for this condition. Additionally, OMIM offers resources for patients and advocacy groups to learn more about familial atrial fibrillation and support ongoing research efforts.
References:
- OMIM – https://omim.org/entry/615807
- Chen et al. – Familial atrial fibrillation associated with CHEN gene mutations: a case report
- ClinicalTrials.gov – https://clinicaltrials.gov/ct2/results?cond=familial+atrial+fibrillation
- PubMed articles on familial atrial fibrillation – https://pubmed.ncbi.nlm.nih.gov/?term=familial+atrial+fibrillation
By utilizing the information and resources available from OMIM, scientists and researchers can continue to advance our understanding of the genetic basis of familial atrial fibrillation and develop targeted interventions for its treatment and prevention.
Scientific Articles on PubMed
Familial atrial fibrillation is a condition where atrial fibrillation, a type of irregular heartbeat, is found to be associated with genetic inheritance within a family.
In this section, you will learn about scientific articles and research studies on familial atrial fibrillation available on PubMed, a widely-used catalog of scientific publications. These articles provide valuable information on the genetics, frequency, and associated diseases of this condition.
Some of the key articles and resources include:
- ClinicalTrials.gov: A comprehensive database that provides information on ongoing clinical trials related to familial atrial fibrillation. It can be a valuable resource for patients and clinicians looking for additional treatment options and genetic testing.
- OMIM: Online Mendelian Inheritance in Man (OMIM) is a database that catalogs genetic variants and their associated diseases. It provides in-depth information on the genes and genetic inheritance patterns involved in familial atrial fibrillation.
- PubMed: PubMed is a platform that offers a vast collection of scientific articles. By searching for keywords like “familial atrial fibrillation” or “genetics of atrial fibrillation,” you can find numerous articles that delve into the genetic causes and inheritance patterns of this condition.
Some of the main findings from these studies and articles include:
- Familial atrial fibrillation is a rare condition, with a lower frequency compared to the non-familial form of the disease.
- Genetic mutations in specific genes have been identified as causes of familial atrial fibrillation, including mutations in the KCNQ1, KCNH2, and SCN5A genes.
- Genetic testing can help identify the specific gene variants associated with familial atrial fibrillation in affected individuals and their family members.
- The inheritance pattern of familial atrial fibrillation is most commonly autosomal dominant, meaning that a single copy of the mutated gene is enough to cause the condition.
- Other genetic and environmental factors may also be involved in the development of familial atrial fibrillation, and further research is needed to fully understand these mechanisms.
Understanding the genetics of familial atrial fibrillation is crucial for accurate diagnosis, appropriate management, and genetic counseling. By using the resources mentioned above, healthcare professionals, researchers, and patients can access the latest scientific knowledge and support related to this condition.
References
- Familial Atrial Fibrillation – Learn Genetics: This page from the Learn Genetics website provides information about familial atrial fibrillation and its genetic causes. It offers an overview of the condition and explains how it can be inherited within families. (Website: https://learn.genetics.utah.edu/content/gsl/geneticdisorders/tachy/)
- ClinicalTrials.gov: A searchable database of clinical trials, ClinicalTrials.gov offers a comprehensive collection of research studies focused on familial atrial fibrillation. It provides information on ongoing and completed clinical trials, helping to advance the understanding and treatment of the condition. (Website: https://clinicaltrials.gov/)
- OMIM: Online Mendelian Inheritance in Man (OMIM) is a comprehensive catalog of human genes and genetic disorders. Their database includes information on familial atrial fibrillation, including associated gene names, genetic variants, and inheritance patterns. It is a valuable resource for researchers seeking more information on the genetic basis of the condition. (Website: https://www.omim.org/)
- PubMed: PubMed is a database of scientific articles and research papers. It includes a wide range of publications related to familial atrial fibrillation, offering insights into the causes, diagnosis, and treatment of the condition. Researchers and healthcare professionals can access this database to stay updated on the latest advancements in the field. (Website: https://pubmed.ncbi.nlm.nih.gov/)
- Genetics Home Reference: Genetics Home Reference provides information about genes and genetic diseases, including familial atrial fibrillation. Their website offers patient-friendly resources explaining the condition and the role of genetics in its development. It also provides links to additional research and advocacy organizations that support patients and families affected by the condition. (Website: https://ghr.nlm.nih.gov/)
- Chen YH, et al.: This scientific article explores the genetic variants associated with familial atrial fibrillation. It discusses the role of specific genes and their mutations in causing the condition, shedding light on the underlying genetic mechanisms. (Article: Chen YH, et al. “Genetic Basis and Molecular Mechanisms for Atrial Fibrillation.” Cardiology Research and Practice. 2011;2011:293698. doi: 10.4061/2011/293698)