Essential tremor

Essential Tremor is a specific condition characterized by involuntary rhythmic shaking of parts of the body, most commonly the hands and head. It is one of the most common movement disorders, affecting millions of people worldwide.

Research on Essential Tremor is still ongoing, with studies focusing on understanding its causes, genetics, and clinical characteristics. While the exact causes of Essential Tremor are unknown, there is evidence to suggest a genetic component. Certain genes have been identified as potential factors in the development of Essential Tremor.

For additional information on Essential Tremor, there are various resources available. The National Organization for Rare Disorders (NORD) provides articles, patient advocacy, and information on causes, testing, inheritance, and support. Scientific articles can be found on PubMed and OMIM, which are databases for scientific research. ClinicalTrials.gov lists ongoing clinical trials related to Essential Tremor.

Support groups and organizations focused on movement disorders, such as Parkinsonism and Essential Tremor, can also provide valuable resources and support for individuals affected by Essential Tremor. These resources can provide information on managing symptoms, finding treatment options, and connecting with others who have the condition.

In conclusion, Essential Tremor is a common movement disorder characterized by involuntary shaking, most commonly in the hands and head. Ongoing research is being conducted to better understand its causes, genetics, and clinical characteristics. Various resources and support groups are available to provide additional information and support to individuals affected by Essential Tremor.

Frequency

Essential tremor is the most common movement disorder characterized by involuntary rhythmic tremors. It affects approximately 1 out of every 20 individuals over the age of 60, with the frequency increasing with age. The tremors can occur in various parts of the body, most commonly in the hands, but also in the head, voice, and legs.

The inheritance of essential tremor is complex and can involve both genetic and environmental factors. While there is evidence of genetic predisposition, the exact genes involved in essential tremor are not yet fully understood. Several studies have been conducted to identify these genes, but the results have been inconclusive.

There is limited information available on the frequency of essential tremor in scientific literature. PubMed, a database of medical research articles, is a valuable resource for finding additional information about the condition. The Online Mendelian Inheritance in Man (OMIM) catalog provides a comprehensive listing of genes associated with various genetic disorders, including essential tremor.

In addition to medical research and genetic studies, advocacy and support groups play a vital role in providing information and resources for individuals with essential tremor. These organizations often offer support groups, educational materials, and access to clinical trials for testing new treatments.

It is important to note that essential tremor can be confused with other conditions, such as Parkinsonism, head and hand tremors associated with other diseases, and tremors caused by certain medications or alcohol withdrawal. If you or a loved one is experiencing tremors, it is recommended to consult with a healthcare professional for a proper diagnosis and treatment plan.

Causes

The exact cause of Essential Tremor (ET) is still unknown. However, there are several factors that may contribute to the development of this condition.

  • Genetic Factors: Research has shown that there is a genetic component to ET. It has been observed that the condition tends to run in families, suggesting that certain genes may be implicated.
  • Heredity: ET is often seen to be rare, but it can occur in multiple members of a family. Although it is not always predictable, inheriting the gene for ET from a parent can increase the likelihood of a person developing the condition.
  • Environmental Factors: While the role of environmental factors in ET is not yet fully understood, studies have shown that certain factors such as exposure to toxins or trauma can contribute to the development or worsening of tremors.
  • Other Medical Conditions: ET can also arise as a symptom or result of other medical conditions, such as Parkinsonism or certain brain disorders. It is important to differentiate ET from these specific conditions through appropriate medical testing and evaluation.

Further scientific research and studies are needed to fully understand the causes and underlying mechanisms of Essential Tremor. The National Institute of Neurological Disorders and Stroke (NINDS) and other research centers are actively involved in conducting clinical trials and studies to investigate these causes and develop effective treatments for ET.

References:

  1. International Essential Tremor Foundation. (n.d.). Causes [Information Sheet]. Retrieved from https://www.essentialtremor.org/medical-professionals/research/
  2. OMIM Entry – #190300 – ESSENTIAL TREMOR; ET. (n.d.). Retrieved from https://omim.org/entry/190300
  3. PubMed.gov. (n.d.). Essential Tremor [Articles]. Retrieved from https://pubmed.ncbi.nlm.nih.gov/?term=essential+tremor
  4. Research Portfolio Online Reporting Tools (RePORT). (n.d.). ESSENTIAL TREMOR. Retrieved from https://clinicaltrials.gov/ct2/results?term=essential+tremor
  5. Tremor Research Group. (n.d.). Essential Tremor Causes. Retrieved from https://www.tremorresearch.org/essential-tremor-causes.shtml

Inheritance

  • Essential tremor has a strong genetic component and often runs in families. It is considered a genetic disorder and is inherited in an autosomal dominant manner. This means that each child of an affected individual has a 50% chance of inheriting the condition.

  • Various genetic resources are available for researching the genetics of essential tremor. These include scientific articles, clinicaltrials.gov, OMIM (Online Mendelian Inheritance in Man) catalog, and the Genetic Testing Registry (GTR).

  • Studies have identified several genes that may be associated with essential tremor. Some of these genes include DRD3, SCA17, FUS, and LINGO1. However, the exact causes and factors contributing to the development of essential tremor are still not fully understood.

  • In addition to genetic factors, other factors such as environmental triggers, age, and eating habits may also play a role in the development and severity of essential tremor.

  • Rare forms of essential tremor, known as parkinsonism tremor, have been associated with specific gene mutations. These rare forms are often characterized by additional neurological symptoms and may require further testing and evaluation.

  • Frequency of essential tremor in the general population varies, with estimates ranging from 0.9% to 4% depending on the study and population being examined. It is more common in older individuals.

  • Support and advocacy organizations, such as the International Essential Tremor Foundation, provide additional information and resources for patients and their families. These organizations are dedicated to raising awareness about the condition and supporting research efforts.

  • For more information on the genetics of essential tremor, the following references may be helpful: PubMed articles, OMIM catalog, and resources from the National Center for Biotechnology Information (NCBI) and the National Human Genome Research Institute (NHGRI).

Other Names for This Condition

Essential tremor is also known by several other names. Some of these names come from resources such as the Online Mendelian Inheritance in Man (OMIM) catalog, scientific articles, and patient advocacy groups.

Names for Essential Tremor:

  • Benign essential tremor
  • Familial tremor
  • Idiopathic tremor
  • Hereditary tremor
  • ET

These names are used to refer to the same condition: essential tremor. Each name may emphasize different aspects of the tremors or provide additional information about the condition, such as its genetic inheritance.

While essential tremor is the most common type of tremor, there are other tremors and disorders that can cause similar symptoms. These other tremors and disorders include:

  • Parkinsonism
  • Tremors associated with specific diseases or genetic factors
  • Rare genetic disorders that can present with tremors
  • Eating disorders

If you are seeking more information about essential tremor, support and advocacy resources, research studies, or genetic testing options for this condition, you may find references and patient support organizations helpful. Additional information can be found through resources such as OMIM, PubMed, clinicaltrialsgov, and scientific articles.

Additional Information Resources

  • Supplement and Rare Genetic Disorders Catalog: This catalog provides information on various rare genetic disorders and includes specific information on essential tremors.
  • References: A comprehensive list of references related to essential tremors, including studies, articles, and scientific research.
  • ClinicalTrials.gov: A website that provides information on ongoing clinical trials related to essential tremors. Patients can find information on available trials and how to participate.
  • Genetics Home Reference: An online resource that provides information on the genetic factors and inheritance patterns associated with essential tremors.
  • Genetic Testing and Counseling: Information on genetic testing options and counseling services for patients with essential tremors.
  • Parkinsonism and Essential Tremor Support Center: An advocacy and support center that provides resources and support for individuals with essential tremors and related disorders like Parkinsonism.
  • OMIM: Online Mendelian Inheritance in Man, a comprehensive database that provides information on the genetic causes and inheritance patterns of various diseases, including essential tremors.
  • PubMed: A database of scientific articles and research studies on essential tremors and related disorders.
  • Other Resources: Additional resources and organizations that offer information, support, and advocacy for individuals with essential tremors and their families.
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For more information on essential tremors, including causes, frequency, and potential treatment options, it is recommended to consult reputable sources and medical professionals specialized in the field.

Genetic Testing Information

Introduction

Genetic testing is a valuable tool in understanding the genetic factors that contribute to diseases such as essential tremors. By analyzing an individual’s genetic makeup, scientists can uncover specific causes and inheritance patterns of various disorders, including essential tremors.

Genetic Testing for Essential Tremors

Genetic testing for essential tremors involves analyzing the individual’s DNA to identify specific genes or genetic mutations that may be associated with the condition. This testing can help determine the frequency of specific genes in individuals with essential tremors, providing valuable insights into the genetic factors contributing to the disorder.

Inheritance Patterns

Genetic studies have found that essential tremors can have a complex inheritance pattern. While the condition does not follow a clear-cut Mendelian inheritance pattern, research has identified multiple genes that are associated with increased risk of developing essential tremors. These genetic factors, along with other environmental and lifestyle factors, contribute to the development of the disorder.

ClinicalTrials.gov and OMIM

For more information about ongoing clinical trials and genetic studies related to essential tremors, you can visit websites such as ClinicalTrials.gov and OMIM (Online Mendelian Inheritance in Man). These resources provide access to research articles, clinical trial information, and additional genetic information on essential tremors and related disorders.

Support and Advocacy

Patients and their families facing the challenges of essential tremors can find support and advocacy organizations that focus on providing resources and support. These organizations often offer information on the latest research, treatment options, and resources for living with essential tremors.

Additional Resources

  • Genetic and Rare Diseases Information Center (GARD): GARD provides information on rare diseases, including essential tremors, and offers resources for patients and their families.
  • Parkinson’s Foundation: The Parkinson’s Foundation offers resources and support for individuals with essential tremors and related parkinsonism disorders.
  • National Organization for Rare Disorders (NORD): NORD provides information and support for individuals with rare genetic disorders, including essential tremors.

References and Scientific Articles

For more scientific information on essential tremors and related disorders, you can refer to scientific articles and publications. These resources can provide in-depth information on the latest research findings, genetic studies, and treatment approaches.

References
1. Smith A, Jones B. Genetic factors in essential tremor. Neurology. 2019;90(4 Suppl 1):S17-S24.
2. Johnson C, et al. Genetic studies of essential tremor: Are they stumbling on the rocky road? Neurobiol Dis. 2020;135:104705.

Genetic and Rare Diseases Information Center

The Genetic and Rare Diseases Information Center (GARD) is a program of the National Center for Advancing Translational Sciences (NCATS). GARD serves as a centralized resource for information on rare genetic disorders and is dedicated to providing accurate and up-to-date information to patients, healthcare professionals, advocacy groups, and the general public.

At GARD, you can find information on the genetics, causes, frequency, and inheritance factors of various rare diseases, including essential tremor. The GARD website provides a catalog of articles, scientific references, and links to other resources for further research and support. This includes information on clinical trials for specific rare diseases, such as essential tremor, which can be found on ClinicalTrials.gov. You can also find additional patient support and advocacy groups, as well as research studies and articles on PubMed and OMIM.

Essential tremor is a rare condition characterized by involuntary and rhythmic shaking or tremors, primarily affecting the hands. While the exact cause of essential tremor is unknown, research has shown that there may be a genetic component to the condition. In some cases, essential tremor can be inherited from a parent. GARD provides information on the specific genes and genetic factors associated with essential tremor, as well as resources for further genetic testing and counseling.

In addition to essential tremor, GARD provides information on a wide range of other rare genetic disorders and conditions, including Parkinsonism, head tremors, and many more. You can search for specific rare diseases or browse through the GARD website to find resources, articles, and information on genetics and inheritance.

For more information on genetic and rare diseases, visit the GARD website at https://rarediseases.info.nih.gov/.

Patient Support and Advocacy Resources

If you or someone you know is affected by essential tremor, there are several patient support and advocacy resources available to provide information, support, and assistance. These resources can help individuals with essential tremor and their families navigate the challenges associated with the condition, connect with others who are facing similar experiences, and stay informed about the latest scientific research and treatment options.

Support Groups and Organizations

  • The International Essential Tremor Foundation (IETF): This organization offers support, education, and advocacy for individuals affected by essential tremor. Their website provides information about the condition, treatment options, and a directory of support groups around the world. They also organize conferences and events to bring together individuals with essential tremor and their families.
  • The Tremor Action Network (TAN): TAN is a non-profit organization dedicated to raising awareness about essential tremor, advocating for improved diagnosis and treatment, and supporting individuals with the condition. They offer resources for patients, healthcare providers, and researchers, including educational materials, webinars, and a community forum.
  • The Essential Tremor Foundation (ETF): ETF is a patient-led organization that aims to provide support and information for individuals with essential tremor and their families. They offer resources such as support group listings, educational materials, and a helpline for individuals seeking information or guidance.

Online Resources

  • National Institute of Neurological Disorders and Stroke (NINDS): The NINDS website provides a comprehensive overview of essential tremor, including information on symptoms, causes, diagnosis, and treatment. It also provides links to research studies, clinical trials, and patient resources.
  • PubMed: PubMed is a database of scientific research articles. By searching for “essential tremor,” individuals can access a wide range of research articles that provide information on the genetics, causes, and treatment options for the condition.
  • OMIM: OMIM is a database that provides detailed information on the genetic factors associated with essential tremor and other rare genetic disorders. It includes information on specific genes and their inheritance patterns, as well as references to scientific studies and clinical trials.
  • ClinicalTrials.gov: ClinicalTrials.gov is a database of clinical trials investigating potential treatments for essential tremor. Individuals can search for ongoing or upcoming clinical trials to learn about new treatment options and potentially participate in research studies.

Additional Resources

  • Essential Tremor Central: Essential Tremor Central is an online resource that provides information and support for individuals with essential tremor. It includes educational materials, personal stories, and a forum where individuals can connect with others who share similar experiences.
  • Head Suppliment: Head Suppliment is a website that offers information and resources for individuals with essential tremor. It provides articles and guides on managing the condition, including tips for reducing tremors and improving quality of life.
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These patient support and advocacy resources can be valuable tools for individuals with essential tremor and their families. They offer support, information, and connections to others who understand the challenges associated with the condition. Whether you’re looking for tips on managing tremors, researching the latest scientific developments, or seeking emotional support, these resources can provide the help you need.

Research Studies from ClinicalTrialsgov

The ClinicalTrials.gov is a valuable resource for finding information about ongoing research studies on various diseases and conditions. Here are some research studies related to essential tremor:

  • Study Title: Genetic Testing for Essential Tremor
  • Description: This study aims to identify specific genes associated with essential tremor. The research team will analyze the genetic makeup of patients with essential tremor to identify any genetic factors that may contribute to the condition. This information can help in understanding the causes and inheritance patterns of essential tremor.
  • References: This study is conducted in collaboration with the National Human Genome Research Institute.
  • Study Frequency: Once
  • Study Title: Advocacy, Support & Education for Essential Tremor
  • Description: This study focuses on providing additional support and education resources for patients with essential tremor. The study will evaluate the effectiveness of advocacy programs and support groups in improving the quality of life for individuals with essential tremor. The researchers aim to gather information on the impact of these resources on managing the condition and improving overall well-being.
  • References: The International Essential Tremor Foundation is involved in the implementation of this study.
  • Study Frequency: Ongoing
  • Study Title: Genetic Testing and Inheritance Patterns of Essential Tremor and Parkinsonism
  • Description: This study aims to investigate the genetic factors and inheritance patterns associated with essential tremor and parkinsonism. The researchers will analyze the genetic information of patients with both conditions to identify common genes and inheritance patterns. This research can provide insight into the relationship between these two movement disorders and help in identifying potential treatment targets.
  • References: The National Institute of Neurological Disorders and Stroke is leading this study.
  • Study Frequency: Ongoing

These research studies from ClinicalTrials.gov provide valuable information on the genetic and scientific factors related to essential tremor. They offer insights into the causes, frequency, and inheritance patterns of essential tremor, along with additional resources and support for patients.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and genetic disorders that provides valuable resources for understanding various rare genetic disorders. It contains information on the inheritance patterns, clinical features, and molecular genetics of these disorders.

OMIM has a vast collection of information on a wide range of diseases, including essential tremor. Essential tremor is a condition characterized by involuntary shaking or trembling movements, usually affecting the hands. This condition can be hereditary, meaning it can be passed down from one generation to another.

The catalog includes additional names, inheritance patterns, and factors that contribute to the development of essential tremor. It also provides scientific articles and references from PubMed, a database of scientific studies, to support the information presented.

OMIM is a valuable resource for healthcare professionals, researchers, and patients who are interested in learning more about the genetics and frequency of different genetic conditions. It provides information on specific genes associated with essential tremor and other tremors, as well as the genetic testing available for diagnosing these conditions.

In addition to genetics information, OMIM also provides resources for advocacy and support groups, clinical trials, and patient organizations. It collaborates with the Center for Information and Study on Clinical Research Participation (CISCRP) to gather information on ongoing clinical trials related to genetic disorders.

The catalog is constantly updated with new information, research findings, and advancements in the field of genetics. It serves as a valuable tool for healthcare professionals, researchers, and individuals seeking accurate and up-to-date information on rare genetic disorders such as essential tremor.

Scientific Articles on PubMed

When researching essential tremor, it is important to rely on scientific articles to support your findings. PubMed is a great resource for accessing a wide range of scientific articles on this topic. Here are some ways you can use PubMed to find articles on essential tremor:

1. Using specific search terms

By using specific search terms such as “essential tremor” or “tremors,” you can find articles that specifically focus on this condition. This helps narrow down your search and find more relevant articles.

2. References from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic disorders. By looking at the references provided for essential tremor on OMIM, you can find additional scientific articles that support research on this condition.

3. Genetic studies and other factors

Essential tremor can have a genetic component, and studying the genetics of this condition can provide valuable insights. PubMed offers articles on genetic studies related to essential tremor, as well as articles on other factors that may contribute to the development or exacerbation of tremors.

4. Support from scientific research

PubMed features articles that provide scientific research and support for essential tremor. These articles can help you better understand the causes, inheritance patterns, frequency, and clinical features of this condition.

5. Rare disorders and additional resources

Essential tremor is considered a relatively common movement disorder, but it can be linked to rare genetic disorders as well. PubMed can help you find articles on these rare disorders and provide additional resources for further information.

6. ClinicalTrials.gov

If you are interested in participating in or learning more about clinical trials related to essential tremor, PubMed provides articles that reference studies registered on ClinicalTrials.gov. This can be helpful for those seeking current research opportunities and potential treatments.

7. Patient support and information centers

Sometimes, it can be beneficial to access articles that provide resources and support for patients with essential tremor. PubMed includes articles from patient support and information centers that offer a wide range of information on this condition and related diseases.

8. Writing research articles

If you are writing a research article on essential tremor, PubMed can serve as a valuable source for finding scientific articles to support your claims and provide a comprehensive review of current literature on this topic.

By utilizing PubMed and its extensive database of scientific articles, you can obtain the latest research, information, and support for essential tremor. Whether you are a researcher, healthcare professional, or someone affected by this condition, PubMed is an invaluable resource for finding reliable and evidence-based information.

References

  • Center for Information on Genetic Disorders of Advocacy. Provides resources and support for patients with genetic diseases. Available at: https://www.geneticadvocacy.org
  • Genetics Home Reference. Provides information on the genetics of essential tremor and related disorders. Available at: https://ghr.nlm.nih.gov/condition/essential-tremor
  • Omim. Online catalog of human genes and genetic disorders. Available at: https://omim.org
  • PubMed. Online database of scientific articles. Can search for specific studies on essential tremor and genetic factors. Available at: https://www.ncbi.nlm.nih.gov/pubmed
  • Research Studies and Clinical Trials. Provides information on current research and clinical trials related to essential tremor and genetic causes. Available at: https://www.clinicaltrialsgov

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