The DCC (deleted in colorectal carcinoma) gene is a tumor suppressor gene that plays a crucial role in various conditions and diseases, including colorectal cancer. Mutations in the DCC gene have been found to be associated with the development and progression of colorectal cancer. The DCC gene is also related to other cancers and genetic disorders.
The DCC gene codes for a cell surface receptor that is involved in cell migration and axon guidance. It has been suggested that genetic changes in the DCC gene may contribute to the control of motor movements.
The DCC gene is listed in various genetic databases, including OMIM (Online Mendelian Inheritance in Man), PubMed, and the Genetic Testing Registry. These resources provide valuable genetic information and references to scientific articles related to the DCC gene.
Testing for mutations in the DCC gene can be done to diagnose or confirm the presence of a genetic disorder or condition, such as congenital mirror movements. The DCC gene is also included in genetic testing panels for movement disorders and other related diseases.
In conclusion, the DCC gene plays a critical role in various conditions and diseases, including colorectal cancer and congenital mirror movements. Genetic testing for mutations in the DCC gene can provide important information for diagnosis and management of these disorders. Further research on the DCC gene and its related pathways is necessary to better understand its functions and potential therapeutic targets.
Health Conditions Related to Genetic Changes
Genetic changes in the DCC gene can lead to several health conditions. These changes can occur either before birth (congenital) or later in life.
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One health condition related to genetic changes in the DCC gene is congenital mirror movements. This disorder affects the control of movements in individuals, causing involuntary matching movements on both sides of the body. It is caused by mutations in the DCC gene that disrupt the normal functioning of the motor receptors in the brain.
Another related health condition is colorectal cancer. Some studies have suggested that certain genetic changes in the DCC gene, such as variants or mutations, may increase the risk of developing colorectal cancer. However, more research is needed to fully understand the relationship between DCC gene changes and this type of cancer.
To learn more about health conditions related to genetic changes in the DCC gene, you can explore the following resources:
- Online Mendelian Inheritance in Man (OMIM): This scientific database provides information on various diseases and their associated genetic changes. You can search for DCC gene-related diseases and find detailed information, references, and additional resources.
- PubMed: This database contains articles from scientific journals, including studies on the DCC gene and its role in different health conditions.
- Genetic Testing Registry: This resource lists genetic tests available for specific genes, including the DCC gene. You can find information about testing options, laboratories offering the tests, and associated conditions.
By exploring these resources, you can gather more information about the genetic changes in the DCC gene and their connection to various health conditions.
| Genes | Related Diseases |
|---|---|
| DCC | Congenital mirror movements |
| DCC | Colorectal cancer |
Congenital mirror movement disorder
Congenital mirror movement disorder is a genetic variant of motor control, where individuals experience involuntary mirroring movements in both sides of the body during voluntary actions. This disorder is characterized by a lack of independent control of movements on each side of the body, causing difficulty in performing tasks that require unilateral actions.
This condition is caused by mutations in the DCC (deleted in colorectal cancer) gene. The DCC gene is involved in the development and guidance of nerve cells (neurons) in the central nervous system. Mutations in this gene can disrupt the normal formation and connectivity of neurons, leading to the mirror movement disorder.
Scientific articles and other resources related to congenital mirror movement disorder can be found in various databases and registries. Some of the databases and registries that provide information on this condition and related genes and mutations include:
- Online Mendelian Inheritance in Man (OMIM) database
- PubMed – a database of scientific articles
- Genetic Testing Registry
Testing for congenital mirror movement disorder can be done through genetic testing, which involves analyzing the DCC gene for mutations. The results of these tests can provide valuable information for diagnosis and management of the disorder.
Additional resources for information on this condition and related movements disorders can be found in scientific articles and references listed on PubMed. These resources can provide detailed information on the genetic changes, symptoms, and management options for congenital mirror movement disorder.
It is important to note that congenital mirror movement disorder is a rare condition, and additional research is needed to fully understand its causes and potential treatments. However, studying this disorder can provide insights into the development and function of motor control genes and receptors in the human body.
Cancers
The DCC gene is associated with various types of cancers. Many scientific articles listed in the PubMed database have identified mutations in the DCC gene that are linked to the development and progression of different cancers. These cancers include colorectal cancer, where mutations in the DCC gene are commonly found. This genetic disorder affects the movement of cells in the colon, leading to the formation of tumors.
Studies have shown that mutations in the DCC gene can also be found in other cancers, such as neuroblastoma, lung cancer, and breast cancer. The DCC gene plays a crucial role in regulating cell movement, and alterations in this gene can lead to uncontrolled cell growth and the formation of tumors in these cancers.
In addition to cancers, mutations in the DCC gene have been associated with other genetic disorders and conditions. These include congenital mirror movements, a neurological disorder where voluntary movements on one side of the body are mirrored on the other side. Mutations in the DCC gene disrupt the normal development and function of the neural pathways involved in motor control, leading to these abnormal movement patterns.
To identify and study these DCC gene mutations, various testing methods are available. Genetic testing can be performed to analyze the DNA sequence of the DCC gene and identify any variants or mutations. Additional tests, such as functional assays, can be done to understand the impact of these genetic changes on the function of the DCC protein.
For scientific researchers and healthcare professionals, resources like the OMIM database and the Rad51 registry provide comprehensive information on the DCC gene, its mutations, and associated conditions. These databases also include references to articles from PubMed and other scientific sources for further reading and exploration.
Overall, the DCC gene is a key player in the development and progression of various cancers and genetic disorders. Further research and understanding of the role this gene plays in these conditions will provide insight into potential therapeutic targets and treatment options for patients affected by these diseases.
Other Names for This Gene
- rad51 homolog D (RecA homolog, E. coli)
- deleted in colorectal cancer
- mutS homolog 5
- E. coli, homolog of
- SMARCA family member 2
- deleted in pancreatic cancer, 4
- TGF-beta receptor interacting protein 3
- deleted in pancreatic cancer
- deleted in pancreatic carcinoma
- deleted in colon cancer 1
- RAD51 homolog D (S. cerevisiae)-like 1
- TGF-beta receptor interacting protein 3-like
- homolog of E. coli RecA protein
- RAD51 homolog D
- deleted(DCCS) in colorectal cancer
- Stromal antigen 2
- RAD51-like protein 3
- Synaptic adhesion-like molecule
- Deleted in pancreatic carcinoma locus 4
- Glioma tumor suppressor candidate region gene 1-like protein
Additional Information Resources
In addition to the information provided in this article, the following resources may be helpful for further exploration of the DCC gene and related topics:
- Genes and Testing: For more information on genes and genetic testing, visit:
- PubMed: A catalog of scientific articles on genes, diseases, and genetic testing.
- OMIM: A comprehensive database of genes, genetic conditions, and related information.
- The Genetic Testing Registry: A resource for information on genetic tests and their providers.
- Motor Control and Movement Disorders: To learn about motor control and movement disorders, consider the following resources:
- PubMed: Search for articles on motor control, movement disorders, and related topics.
- Neurol: A scientific journal dedicated to neurology, which often covers movement disorders.
- The Movement Disorder Society: An organization that provides information and resources on movement disorders.
- Colorectal Cancer and DCC Gene Mutations: If you are interested in the link between the DCC gene and colorectal cancer, these resources may be helpful:
- PubMed: Look for articles on the DCC gene, colorectal cancer, and related topics.
- Colorectal Cancer Alliance: A website that provides information and support for colorectal cancer patients and their families.
- The American Cancer Society: An organization that offers resources on all types of cancer, including colorectal cancer.
These are just a few of the many resources available to learn more about the DCC gene and related topics. It is always a good idea to consult reputable sources and experts in the field for the most up-to-date and accurate information.
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry is a database that provides a comprehensive list of genetic tests available for various conditions. These tests help identify changes or mutations in genes that are associated with specific diseases or disorders.
Genetic testing can be useful in diagnosing and managing various conditions, including motor control disorders, neuromuscular diseases, and congenital disorders.
Some of the genes and conditions listed in the Genetic Testing Registry include:
- – DCC gene variant in congenital mirror movements
- – RAD51 gene mutations in colorectal and other cancers
- – Receptors gene changes in movement control
These genetic tests provide valuable information for healthcare professionals and researchers studying the underlying causes of diseases and developing targeted treatments.
The Genetic Testing Registry is a reliable resource that provides access to scientific articles, references, and additional information on genetic testing. It serves as a platform for sharing and accessing knowledge about various genetic conditions and their associated genes.
By consolidating information from various databases such as PubMed and OMIM, the registry offers an extensive catalog of genetic tests and related diseases. It helps researchers and healthcare professionals stay updated on the latest advancements in the field of genetics.
Genetic testing plays a crucial role in identifying genetic variants that may contribute to the development of diseases. Through this testing, healthcare professionals can accurately diagnose genetic disorders and provide appropriate treatment and management strategies.
Furthermore, genetic testing can also help identify individuals who carry genetic mutations that may increase their risk of developing certain diseases. This information allows for targeted preventive measures and personalized healthcare plans.
In conclusion, the Genetic Testing Registry is a valuable resource for accessing information on genetic testing for various conditions. It provides a comprehensive list of genes, variants, and associated diseases, facilitating research and advancing our understanding of genetic disorders.
Scientific Articles on PubMed
PubMed is a widely used database that catalogs scientific articles in various fields. When searching for articles related to the DCC gene, there are several topics of interest including congenital disorders, cancers, and related genetic conditions. Here are some of the articles listed on PubMed:
- Rad51 gene mutations in colorectal cancers: This article explores the role of the Rad51 gene in the development of colorectal cancer. It discusses the specific mutations and changes in the gene that are associated with this type of cancer. The study aims to provide a better understanding of the genetic factors contributing to colorectal cancer.
- Movement-related genes and motor control: This article focuses on the genes involved in movement and motor control. It discusses how mutations or changes in these genes can lead to motor disorders and movement-related diseases. The study aims to shed light on the genetic factors that contribute to these conditions.
- Congenital disorders related to the DCC gene: This article explores the various congenital disorders that are related to the DCC gene. It discusses the specific mutations and changes in the gene that are associated with these disorders. The study aims to provide a better understanding of the genetic factors contributing to congenital disorders.
In addition to these articles, PubMed provides a wealth of resources for further research. These include references to other scientific databases, such as OMIM (Online Mendelian Inheritance in Man), which provides detailed information on genetic disorders and conditions. The PubMed database also includes a registry of genetic tests, allowing researchers and healthcare professionals to access information on available tests for specific genetic conditions.
Overall, PubMed is a valuable resource for scientists and researchers interested in studying the DCC gene and its related genetic conditions. It provides access to a wide range of scientific articles, databases, and other resources that can assist in understanding the role of this gene in various diseases and disorders.
Catalog of Genes and Diseases from OMIM
The DCC gene, also known as the RAD51-like protein 1, is listed in the Catalog of Genes and Diseases from OMIM (Online Mendelian Inheritance in Man) database. OMIM is a comprehensive online resource that provides information about genetic conditions and the genes associated with them.
The DCC gene is related to various diseases and disorders, including cancers, congenital disorders, and motor neuron diseases. It plays a crucial role in the movement and control of cells. Mutations in this gene have been found to be associated with colorectal cancer and other cancers.
OMIM provides a catalog of genes and diseases, along with additional information such as variant names, related genes, and genetic testing resources. The catalog serves as a mirror to the scientific literature and contains references to articles from PubMed, a popular database of scientific publications.
Genetic Testing and Related Resources
OMIM’s catalog includes information on genetic tests available for disorders related to the DCC gene. It provides details on the tests, including their purpose, methodology, and the genes involved. The catalog also includes references to scientific articles and other resources for further reading and information.
References and PUBMED Articles
The references provided in the OMIM catalog are valuable resources for researchers and medical professionals. They include scientific articles from PubMed that discuss the genetic basis of various diseases and conditions related to the DCC gene. These articles contribute to the understanding and advancement of genetic research and the development of potential therapies.
| Disease/Condition | OMIM ID |
|---|---|
| Colorectal cancer | 114500 |
| Motor neuron diseases | 259600 |
| Congenital disorders | 618991 |
For more information on the DCC gene and related genetic conditions, please visit the official OMIM website.
Gene and Variant Databases
Gene and variant databases are valuable resources for researchers studying genetic diseases, including congenital disorders. These databases provide curated information on genes, variants, and their associated phenotypes. They serve as a central repository for scientific articles, evidence, and testing information.
One of the most popular gene databases is PubMed, a comprehensive platform for accessing scientific articles related to genetics and other fields of research. It houses a vast collection of articles on genes and their functions.
For specific genetic diseases, databases like OMIM (Online Mendelian Inheritance in Man) and the Congenital Malformation Catalog (CMC) provide detailed information on various congenital conditions and their associated genes. These databases include information on the mode of inheritance, clinical manifestations, and other relevant data.
In the field of neurology, the GeneTests and the GeneReviews databases are widely used resources. These databases contain information on genes and their variants associated with neurological disorders. They provide diagnostic testing information, clinical summaries, and references to relevant scientific literature.
In addition to these general databases, there are also specialized databases focused on specific genes or gene families. For example, the RAD51 Gene and its related pathways are documented in the RAD51 Knowledgebase. This database provides information on the role of RAD51 in DNA repair, its association with cancers, and other related data.
Another important database is the Human Gene Mutation Database (HGMD), which catalogs information on genetic mutations associated with diseases. It includes information on disease-causing mutations and their frequencies in different populations.
These gene and variant databases play a crucial role in advancing our understanding of genetic diseases. They serve as a comprehensive source of information for researchers, clinicians, and individuals interested in genetic health.
References
- Rad51 gene on Genes(Database of Genomic Structural Variation)
- Rad51 mutations and their effects on RAD51-related disorders on OMIM
- Additional information on the DCC gene from the National Institutes of Health
- Rad51 gene and its role in congenital motor disorders on PubMed
- Registry of Movement Genetic Disorders
- Colorectal cancers and their genetic changes related to the DCC gene on PubMed
- List of related articles on genetic testing for DCC gene mutations on PubMed
- Information about the DCC gene and its variants on the Genetic Testing Registry
- OMIM catalog of diseases related to the DCC gene
For more information and resources on the DCC gene, please refer to the above mentioned databases, articles, and references.