Betamethasone Dipropionate Cream – Uses, Side Effects, and More

Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor.

Betamethasone

Generic name: betamethasone topical [ BAY-ta-METH-a-sone-TOP-ik-al ]
Brand names: Alphatrex, Beta-Val, Betaderm, Betanate, Betatrex, . show all 14 brands Del-Beta, Diprolene, Diprosone, Luxiq, Maxivate, Sernivo, Teladar, Uticort, Valisone
Drug class: Topical steroids

Medically reviewed by Carmen Pope, BPharm. Last updated on Apr 13, 2023.

What is betamethasone?

Betamethasone is a highly potent steroid that prevents the release of substances in the body that cause inflammation.

Betamethasone topical (for the skin) is used to treat the inflammation and itching caused by a number of skin conditions such as eczema or psoriasis.

Betamethasone topical is available in a cream, gel, ointment, lotion, foam, or spray.

Topical betamethasone formulations are usually formulated with one of two salts: betamethasone dipropionate or betamethasone valerate. The potency of betamethasone formulations can vary depending on which salt is used – dipropionate or valerate.

Betamethasone dipropionate contains two esters – this makes it more fat soluble and increases its ability to penetrate the skin better. This makes it more potent than betamethasone valerate, which only contains one ester.

The absorption and potency of a topical steroid can also vary depending on the vehicle used to deliver the steroid (such as a cream, gel, lotion, or ointment) and if it has been augmented or not. Augmentation refers to enhancing the vehicle with a substance, such as propylene glycol, to allow it to penetrate the skin more quickly and work faster. For example, augmented betamethasone dipropionate 0.05% ointment or gel is a Class 1 (highly potent) topical steroid, but the augmented lotion or cream and regular betamethasone dipropionate ointment is Class 2.

Potency of betamethasone preparations

Class 1 (highly potent)

• Augmented betamethasone dipropionate 0.05% ointment
• Augmented betamethasone dipropionate 0.05% gel

Class 2 (potent)

• Augmented betamethasone dipropionate 0.05% lotion
• Augmented betamethasone dipropionate 0.05% cream (0.05%)
• Regular betamethasone dipropionate 0.05% ointment

Class 3 (upper medium potency)

• Regular betamethasone dipropionate cream 0.05%

Class 4 and 5 (medium potency)

• Betamethasone valerate foam 0.12%
• Regular betamethasone dipropionate spray 0.05%

Warnings

Do not use betamethasone longer than you have been told to by your doctor. Use care when using on a large part of the skin. Talk with your doctor.

Do not use to treat diaper rash or redness. Avoid applying betamethasone cream, gel, ointment, lotion, foam, or spray to the diaper area.

Different brands of betamethasone may be for use in different ages of children. Talk with the doctor before using betamethasone cream, gel, ointment, lotion, foam, or spray on a child.

If you are breastfeeding, do not apply betamethasone cream, gel, ointment, lotion, foam, or spray to the nipple or the area around it.

Betamethasone may raise the chance of cataracts or glaucoma. Talk to your doctor.

Before taking this medicine

You should not use betamethasone if you are allergic to it.

To make sure betamethasone is safe for you, tell your doctor if you have ever had:

• skin irritation after using steroid medicine;
• thinning of the skin where you will apply betamethasone;
• cataracts or glaucoma;
• diabetes;
• liver disease;
• adrenal gland problems; or
• any type of skin infection.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks. If you apply betamethasone to your chest, avoid areas that may come into contact with the baby’s mouth.

Do not use betamethasone on a child without a doctor’s advice. Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects.

Diprolene is not approved for use by anyone younger than 13 years old. Sernivo and Luxiq are not approved for anyone younger than 18 years old.

How should I use betamethasone ?

Use betamethasone cream, gel, ointment, lotion, foam, or spray exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Do not take by mouth. Topical medicine is for use only on the skin. Do not use on open wounds or on sunburned, windburned, dry, or irritated skin. Rinse with water if this medicine gets in your eyes or mouth.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Wash your hands before and after using this medicine, unless you are using the medicine to treat the skin on your hands.

Apply a small amount to the affected area and rub it gently into the skin. Do not apply betamethasone cream, gel, ointment, lotion, foam, or spray over a large area of skin.

Do not cover the treated skin area unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.

Use betamethasone regularly to get the most benefit. Stop using the medicine once your symptoms clear up.

Call your doctor if your skin condition does not improve after 2 weeks, or if it gets worse.

Do not use Diprolene for longer than 2 weeks in a row. Do not use Sernivo or Luxiq for longer than 4 weeks.

Store at room temperature away from moisture and heat.

The foam is flammable. Do not use near high heat or open flame. Do not smoke until the foam has completely dried on your skin.

Dosing information

Usual Adult Dose for Dermatitis:

Cream, gel, ointment:

• Apply a thin film topically to the affected area 1 or 2 times a day
• Foam, lotion: Apply topically twice a day (morning and night)

• Treatment should be discontinued when control is achieved; if no improvement is seen within 2 weeks, reassessment may be necessary.
• Occlusive dressings should not be used unless directed by a healthcare provider.

Usual Adult Dose for Plaque Psoriasis:

• Apply topically to affected skin areas twice a day; rub in gently
• Duration of Treatment: Up to 4 weeks

• Discontinue therapy when control is achieved; treatment beyond 4 weeks is not recommended.

Use: For the treatment of mild to moderate plaque psoriasis.

Usual Pediatric Dose for Dermatitis:

12 years or older:

• Cream, gel, ointment: Apply a thin film topically to the affected area 1 or 2 times a day
  Foam, lotion: Apply topically twice a day (morning and night)

• Treatment should be discontinued when control is achieved; if no improvement is seen within 2 weeks, reassessment may be necessary.
• Occlusive dressings should not be used unless directed by a healthcare provider.
• Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of children.

Use: Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

What other drugs will affect betamethasone?

Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Long term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using betamethasone?

Do not get betamethasone topical in your eyes. If contact does occur, rinse with water.

Avoid applying betamethasone to the skin of your face, underarms, or groin area without your doctor’s instruction.

Do not use betamethasone to treat any condition that has not been checked by your doctor.

Betamethasone side effects

Get emergency medical help if you have signs of an allergic reaction to betamethasone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using betamethasone and call your doctor at once if you have:

• severe skin irritation where the medicine was applied; or
• signs of skin infection (swelling, redness, warmth, oozing).

Your skin can absorb topical steroid medicine, which may cause steroid side effects throughout the body. Stop using betamethasone and call your doctor if you have:

• blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• slow wound healing, thinning skin, increased body hair;
• increased thirst or urination, dry mouth, fruity breath odor;
• weight gain, puffiness in your face; or
• muscle weakness, tired feeling, depression, anxiety, feeling irritable.

Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common betamethasone side effects may include:

• itching, redness, burning, stinging, or blistering of treated skin;
• skin bruising or shiny appearance; or
• folliculitis (redness or crusting around your hair follicles).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

References

Betamethasone Dipropionate Cream – Uses, Side Effects, and More

This medication is used to treat a variety of skin conditions (such as eczema, dermatitis, allergies, rash). Betamethasone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a strong corticosteroid.

How to use betamethasone dipropionate topical

Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor.

Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor.

Do not cover, bandage, or wrap the area unless directed to do so by your doctor.

If you are using the lotion form of this medication, shake the bottle well before each dose.

After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.

Inform your doctor if your condition lasts or gets worse after 2 weeks.

Side Effects

Burning, itching, irritation, or dryness at the application site may occur when this medication is first applied to the skin. This should disappear in a few days as your body adjusts to the medication. If any of these effects last or get worse, notify your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: stretch marks, skin thinning/discoloration, acne, extreme/unwanted hair growth, small red bumps on the skin (folliculitis).

Skin infections can become worse when this medication is used. Tell your doctor if redness, swelling, or irritation does not improve.

Rarely, it is possible this medication will be absorbed from the skin into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children, and in people who use this medication for a long time or over large areas of the skin. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using betamethasone, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (such as hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, immune system problems.

Do not use if there is an infection or sore present in the area to be treated.

Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.

Though it is unlikely, this medication may temporarily slow down a child’s growth if used for a long time. See the doctor regularly so your child’s height can be checked.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Similar medications pass into breast milk. Consult your doctor before breast-feeding.