Burosumab-twza Injection

Burosumab-twza injection is used to treat X-linked hypophosphatemia (XLH; an inherited disease where the body doesn’t maintain phosphorus and that leads to weak bones) in adults and children 6 months of age and older. It is also used to treat tumor-induced osteomalacia (a tumor that causes a loss of phosphorus in the body that leads to weak bones) that cannot be surgically removed in adults and children 2 years of age and older, Burosumab-twza injection is in a class of medications called fibroblast growth factor 23 (FGF23) blocking antibodies. It works by blocking the action of a certain natural substance in the body which causes the symptoms of XLH.

🔔 How should this medicine be used?

Burosumab-twza injection comes as a solution (liquid) to be injected subcutaneously (under the skin) by a doctor or nurse. For the treatment of X-linked hypophosphatemia, it is usually injected once every 2 weeks for children 6 months to 17 years of age, and once every 4 weeks for adults. For the treatment of tumor-induced osteomalacia, in children 2 to 17 years of age, it is usually injected once every 2 weeks. For the treatment of tumor-induced osteomalacia in adults, it is usually injected every 4 weeks and as the dose is increased it may be injected every 2 weeks. Your doctor or nurse will inject the medication in either your upper arm, upper thigh, buttocks, or stomach area, and use a different injection site each time.

Tell your doctor if you are taking any phosphate supplements or certain vitamin D supplements such as calcitriol (Rocaltrol) or paricalcitol (Zemplar). You will need to stop taking these 1 week before you start treatment.

Your doctor may increase your dose (not more than once every 4 weeks), or may skip a dose, depending on the results of your lab tests.