Levoleucovorin Injection

Levoleucovorin injection is used in adults and children to prevent harmful effects of methotrexate (Trexall) when methotrexate is used to treat osteosarcoma (cancer that forms in bones). Levoleucovorin injection is also used to treat adults and children who have accidentally received an overdose of methotrexate or similar medications or who are not able to eliminate these medications properly from their bodies. Levoleucovorin injection is also used with fluorouracil (5-FU, a chemotherapy medication) to treat adults with colorectal cancer (cancer that begins in the large intestine) that has spread to other parts of the body. Levoleucovorin injection is in a class of medications called folic acid analogs. It works to prevent the harmful effects of methotrexate by protecting healthy cells, while allowing methotrexate to enter and kill cancer cells. It works to treat colorectal cancer by increasing the effects of fluorouracil.

🔔 How should this medicine be used?

Levoleucovorin injection comes as a solution (liquid) and as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a hospital or medical office. When levoleucovorin is used to prevent the harmful effects of methotrexate or treat an overdose of methotrexate, it is usually given every 6 hours, beginning 24 hours after a dose of methotrexate or as soon as possible after an overdose and continuing until laboratory tests show it is no longer needed. When levoleucovorin injection is used to treat colorectal cancer, it is usually given once a day for 5 days in a row as part of a dosing cycle that may be repeated every 4 to 5 weeks.