Is There a Vaccine to Treat Lymphoma?

The Food and Drug Administration (FDA) has yet to approve any vaccines for the treatment of lymphoma. But several different types of lymphoma vaccines are currently being tested in clinical trials.

Lymphoma is a type of cancer that affects the cells of your lymphatic system. These cells are called lymphocytes, and they include B cells and T cells. Both cell types are typically involved in protecting you from infections.

There are two broad types of lymphoma: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma (NHL). The type of treatment recommended and how it affects your outlook depends on the specific type of lymphoma you have.

Lymphoma treatment often involves chemotherapy. However, radiation therapy, targeted therapy, and immunotherapy may also be used. Progress is also being made on vaccine treatments for lymphoma.

Keep reading to learn more.

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We typically think of vaccines as a way to prevent disease. However, vaccines to treat cancer are a little different.

Cancer vaccines are given as a part of cancer treatment to help your immune system recognize and respond to cancer cells. This type of cancer treatment is called immunotherapy.

Currently, the Food and Drug Administration (FDA) has approved two vaccines for cancer treatment. These vaccines target prostate cancer and melanoma. Currently, no vaccines have been approved for the treatment of lymphoma.

However, lymphoma vaccines are being tested in clinical trials. Clinical trials help researchers determine whether a new treatment or therapy is safe and effective before it’s made widely available.

Many of the lymphoma vaccines being studied are for the treatment of NHL, which generally has a poorer outlook than Hodgkin’s lymphoma.

Vaccines for NHL often focus on slow-growing (indolent) lymphomas, which are more challenging to treat. However, the vaccines may also target aggressive types of NHL.

Vaccines may be used to treat cancer in several different ways, and there are different types of vaccines based on how they are made.

Protein-based

Some cancer vaccines contain proteins that are found on cancer cells. This can help teach your immune system to respond to these proteins. Something that causes an immune response is called an antigen.

A 2021 research review notes that, although protein-based cancer vaccines are easy to make and can stimulate the immune system, they have often not shown a benefit in clinical trials. This includes older trials for protein-based lymphoma vaccines, according to another 2021 review .

However, there are some newer protein-based vaccines for treating indolent NHL in clinical trials now.

One, called EO2463, uses four peptides to help your immune system recognize lymphoma cells as foreign. Another, called NeoVax, is personalized and uses antigens present on your own lymphoma cells.

Nucleic acid-based

Nucleic acids include DNA and RNA. Nucleic acid vaccines contain information that can tell your cells how to make a cancer-associated antigen. Once this antigen is made, your immune system can develop a response to it.

A clinical trial of an mRNA vaccine is now recruiting for people with solid tumors or lymphomas. The vaccine is injected into the tumor and contains mRNA that goes on to boost cytokine production, activating immune cells around the tumor.

Cell-based

Some vaccines are made using cells that are isolated from your body. These cells are then exposed to antigens in a lab. This teaches the cells to recognize and respond to the antigen when they’re reinfused into your body.

Sipuleucel-T (Provenge) is an FDA-approved cancer vaccine that uses this method. It’s used to treat advanced prostate cancer that hasn’t responded to other treatments.

One active clinical trial for a cell-based vaccine to treat lymphoma is for Oncoquest-L. The vaccine combines a person’s own tumor cells with a cytokine that stimulates the immune system. It’s being tested for treating indolent NHL.

Virus-based

Virus-based vaccines use a type of virus called an oncolytic virus. This is a virus that’s been modified to infect and kill cancer cells. It also stimulates infected cells to make cytokines, which can activate the immune system.

Talimogene laherparepvec (Imlygic) is an FDA-approved virus-based cancer vaccine. It’s used for melanoma that cannot be removed using surgery.

There are currently no virus-based vaccines being tested for lymphoma.