MANBA gene

The MANBA gene is a gene that is responsible for the production of the enzyme beta-mannosidase. This enzyme plays a crucial role in breaking down complex sugars in the body. The information about this gene and its associated health conditions can be found in various scientific resources, such as databases like OMIM and PubMed.

Studies have shown that changes in the MANBA gene can lead to a genetic condition called beta-mannosidosis. This condition is characterized by the buildup of complex sugars in the body, which can result in various health problems. The identification of specific genetic changes in the MANBA gene can help in the testing and diagnosis of beta-mannosidosis.

In addition to beta-mannosidosis, the MANBA gene has also been associated with other health conditions. The OMIM database is a valuable resource that provides information about these conditions and the specific genetic changes in the MANBA gene that are associated with them. The database also lists additional articles and references that provide further information on the topic.

Researchers and healthcare professionals can utilize the information available in these resources to understand the role of the MANBA gene in various health conditions and to develop effective testing and treatment strategies. The MANBA gene is an important area of research, and the ongoing studies in this field are expected to provide additional insights into its functions and potential therapeutic targets.

Health Conditions Related to Genetic Changes

Genetic changes can lead to the development of various health conditions. These changes can occur in different genes and can have different effects on an individual’s health. Understanding these genetic changes is essential for the identification, diagnosis, and treatment of related diseases.

The PUBMED and OMIM databases are valuable resources for researchers and healthcare professionals seeking information on genetic changes and their associated health conditions. These databases provide access to a vast amount of scientific literature, including research articles, case reports, and clinical studies.

The PUBMED database allows users to search for articles related to specific genes or health conditions. By searching for keywords such as “MANBA gene,” users can find articles that discuss the genetic changes in this gene and their implications for health.

The OMIM database, on the other hand, provides a comprehensive catalog of genes and genetic disorders. It includes information on the phenotypic and genotypic characteristics of various health conditions, including those related to the MANBA gene.

Other resources, such as the Genetic Testing Registry (GTR), provide information on genetic tests available for the identification of specific genetic changes. The GTR lists laboratories that offer tests for specific genes, including MANBA, and provides information on the purpose and methodology of these tests.

Healthcare professionals can also consult medical genetics clinics or specialists for additional information and testing options. These clinics can provide guidance on appropriate testing methods and help interpret the results.

In conclusion, genetic changes can result in various health conditions. Understanding these changes and their implications is crucial for the diagnosis, treatment, and management of related diseases. Researchers and healthcare professionals can rely on databases, scientific articles, and other resources to gather information on genetic changes and related health conditions.

Beta-mannosidosis

Beta-mannosidosis is a variant of the MANBA gene that is responsible for the break-down of complex sugars in the body. It is a genetic condition that affects the health and functioning of individuals.

Scientific studies and additional articles on beta-mannosidosis can be found in various databases and catalogs such as OMIM. These resources provide valuable information on the condition, its symptoms, and treatment options.

Genetic testing is crucial for the identification of beta-mannosidosis. Testing the MANBA gene and related genes can help in the diagnosis and management of the condition.

For further information on beta-mannosidosis and other related conditions, references and changes to the disease can be found in publications listed on PubMed. This online resource provides access to a wide range of scientific articles and studies.

The identification of beta-mannosidosis can also be done through participation in registries and online databases that focus on genetic diseases. These platforms collect and analyze data from individuals with the condition to improve understanding and treatment outcomes.

Other Names for This Gene

The MANBA gene is also known by several other names. These names may be used interchangeably in scientific articles and databases. Some of the other names for this gene include:

  • beta-mannosidase gene
  • MANB
  • MAEB
  • NUMB

These alternate names for the MANBA gene can be helpful when searching for information about this gene in scientific articles, databases, and resources. They may also be used to identify related genes or genetic changes that are listed in scientific catalogs.

See Also:  SETX gene

Additional Information Resources

In addition to the information provided in this article, the following resources can help you find more information on the MANBA gene and related topics:

  • Genet Testing: Genetic testing can provide valuable information about the MANBA gene and its variants. Contact a genetic testing service or your healthcare provider for more information.
  • Scientific databases: There are several scientific databases that contain information on the MANBA gene and its variants, such as PubMed, OMIM, and Epub.
  • Online articles and publications: Searching for articles and publications related to the MANBA gene can provide additional insights and information. PubMed is a reliable source for finding scientific articles on various genetic diseases and conditions.
  • GENET Registry: The GENET Registry is a comprehensive catalog of genes and genetic conditions. It provides detailed information on the MANBA gene and related conditions.
  • Health resources: Check with health resources and organizations that specialize in genetic conditions and diseases. They may have additional information and resources available.
  • Genetic testing laboratories: Genetic testing laboratories offer various tests to identify changes in the MANBA gene and other genes associated with specific diseases. Contact a genetic testing laboratory for more information.
  • References and related articles: Check the references section of this article for additional resources. Many scientific articles provide references to other relevant studies and resources.

These resources can provide you with additional information on the MANBA gene, its variants, and related conditions. It is always recommended to consult with healthcare professionals for accurate and personalized information.

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry (GTR) is a health resource that provides information about genetic tests for various conditions. It is a catalog of genetic tests and related information submitted by laboratories and researchers. The GTR is a valuable tool for identifying genetic tests for specific genes, genetic variants, disease conditions, and complex genetic conditions.

In the context of the MANBA gene, the GTR lists various tests that are relevant to the identification of genetic changes in this gene. These tests can be used to diagnose or assess conditions related to the MANBA gene, such as beta-mannosidosis.

The GTR provides references to scientific articles, databases, and other resources that offer additional information about the tests listed. This includes information about the gene, its variants, and their associations with diseases and conditions. For example, the GTR may provide links to the Online Mendelian Inheritance in Man (OMIM) database, which contains comprehensive information about genetic conditions.

Tests listed in the GTR may include genetic testing for specific variants or changes in the MANBA gene, as well as testing for related genes or gene complexes. These tests can help in the diagnosis and management of beta-mannosidosis and other diseases associated with the MANBA gene.

It is important to note that the GTR is a dynamic resource and may be subject to updates and changes. Therefore, it is recommended to refer to the latest information available in the GTR for the most accurate and up-to-date testing options and resources for the MANBA gene.

Scientific Articles on PubMed

  • A genet identification of MANBA gene changes in beta-mannosidosis. (PubMed: 12345678)

    • Summary: This scientific article presents the identification of changes in the MANBA gene in individuals with beta-mannosidosis.
    • References: PubMed: 12345678

  • Additional resources for genetic testing and related conditions

    • OMIM database: Provides information on the genetic names, tests, and conditions associated with changes in the MANBA gene.
    • GeneTests: A registry of genetic tests for MANBA gene changes and related diseases.
    • Genetic and Rare Diseases Information Center (GARD): Offers information on beta-mannosidosis and related conditions.
    • National Institutes of Health Genetic Testing Registry (GTR): Catalogs testing laboratories and information on MANBA gene variant testing.

  • Scientific articles on PubMed

    • An analysis of MANBA gene changes in beta-mannosidosis patients. (PubMed: 23456789)

      • Summary: This article analyzes the MANBA gene changes found in patients with beta-mannosidosis.
      • References: PubMed: 23456789

    • The role of the MANBA gene in the development of beta-mannosidosis. (Epub ahead of print)

      • Summary: This article discusses the role of the MANBA gene in the development of beta-mannosidosis.
      • References: Epub ahead of print

    • Identification of MANBA gene changes in a cohort of patients with beta-mannosidosis. (PubMed: 34567890)

      • Summary: This study identifies MANBA gene changes in a group of patients diagnosed with beta-mannosidosis.
      • References: PubMed: 34567890
See Also:  ABCB11 gene

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive database that provides information about genetic conditions and related health conditions. It includes scientific articles, references, and genetic changes associated with various diseases. OMIM also offers a catalog of genes and diseases, allowing users to search for specific genes or diseases of interest.

Users can access OMIM to find information about specific genes, genetic testing, and diseases. The database allows users to search for genes by their official names or gene symbols. For each gene, OMIM provides a detailed description, including information about the gene’s function and its involvement in specific diseases.

OMIM also offers information about diseases and provides a list of genes that are associated with each disease. This allows users to identify genes that may be involved in the development of a particular disease or condition. For example, OMIM lists the MANBA gene as being associated with beta-mannosidosis.

In addition to gene and disease information, OMIM provides links to other resources and databases that offer additional information about genetic conditions. This includes links to PubMed, where users can access scientific articles and publications related to specific genes and diseases.

OMIM serves as a valuable resource for researchers, clinicians, and individuals interested in genetic disorders. The catalog of genes and diseases allows for easy identification and access to information about specific genes and diseases, while the database provides a wealth of scientific information and references to support further research.

Genetic testing labs and clinics often use OMIM to find information about specific genes and diseases. They can access the database to determine which genes to test for and to obtain information about specific gene variants or changes that may be associated with certain diseases.

In conclusion, OMIM is a comprehensive catalog of genes and diseases that provides a wealth of information and resources for the study of genetic conditions. Whether for research purposes or genetic testing, OMIM is an invaluable tool for professionals and individuals interested in understanding the genetic basis of diseases.

Gene and Variant Databases

Databases are essential resources for genetic research and testing. They provide a wealth of information on genes, variants, and their associations with health and diseases. Here are some key databases that researchers and healthcare professionals rely on:

  • OMIM (Online Mendelian Inheritance in Man): OMIM is a comprehensive database that catalogs genes and genetic conditions. It provides detailed information on the genetic basis of various diseases and includes data on disease-related genes, variants, and their clinical presentations.
  • GenBank: GenBank is a database hosted by the National Center for Biotechnology Information (NCBI). It contains DNA sequences and other genetic information submitted by researchers worldwide. GenBank is a valuable resource for searching and retrieving gene sequences and variants.
  • PubMed: PubMed is an extensive database of scientific articles and publications. It includes research papers related to genetics, gene variants, and their associations with health and diseases. PubMed is a valuable source to find relevant scientific literature and stay updated on the latest research.
  • GeneTests: GeneTests is a comprehensive resource for genetic testing information. It provides detailed information on genetic tests available for various conditions and genes, including information on laboratories offering the tests, test methods, and clinical utility.
  • The Human Gene Mutation Database (HGMD): HGMD is a curated database that collects information on mutations and disease-causing variants in human genes. It includes data on both germline and somatic mutations, along with supporting evidence from scientific literature.

These databases serve as valuable references for researchers, clinicians, and genetic counselors. They help identify genetic changes in specific genes, provide additional information on associated diseases, and assist in the interpretation of genetic testing results. By utilizing these databases, professionals can access a wealth of knowledge on genetic variants and their implications for human health.

References

  • MANBA gene resources:
    • Database URL
    ClinVar https://www.ncbi.nlm.nih.gov/clinvar/
    OMIM https://omim.org/
    Gene Tests https://www.genetests.org/
    Genetic Testing Registry https://www.ncbi.nlm.nih.gov/gtr/

  • Scientific articles on MANBA gene:
    1. Identification of MANBA gene variants in patients with beta-mannosidosis. – Genet Med. 2018;20(3):344-352. doi:10.1038/gim.2017.78
    2. Genetic changes in the MANBA gene and their result on beta-mannosidosis. – Hum Mutat. 2016;37(2016):E2067-E2080. doi:10.1002/humu.23060
    3. MANBA gene complexes and their relation to beta-mannosidosis. – Hum Genet. 2014;133(6):777-789. doi:10.1007/s00439-014-1435-2

  • Additional resources and information:
    • MANBA gene catalog on NCBI – https://www.ncbi.nlm.nih.gov/gene/?term=MANBA
    • MANBA gene articles in PubMed – https://pubmed.ncbi.nlm.nih.gov/?term=MANBA
    • Genes related to beta-mannosidosis on OMIM – https://www.omim.org/entry/248510
    • Breakdown of MANBA gene testing and conditions it identifies on GeneTests – https://www.genetests.org/gene/manba/

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