The IRGM gene, also known as Immunity-Related GTPase Family M protein, is a gene that plays a role in the immune system and is associated with various diseases. This gene has been found to be involved in the risk of developing certain conditions, such as Crohn’s disease, tuberculosis, and other bacterial infections.

Tests have been developed to analyze the genetic variations in the IRGM gene and assess the risk of developing these diseases. By testing for specific variants in this gene, individuals can gain valuable information about their genetic predisposition to certain health conditions.

Information about the IRGM gene and its associated diseases can be found in various scientific databases and resources. These include PubMed, OMIM, and genetic testing registries. Additional articles and references related to this gene can be found in scientific publications, providing further insights into its role in disease development and progression.

Researchers and geneticists have been studying the IRGM gene extensively to understand its functions and implications in various diseases. The catalog of genetic variants in this gene and related conditions continues to expand, with ongoing research providing new insights into its role in different health conditions.

In conclusion, the IRGM gene is a significant gene associated with a range of diseases, and genetic testing can provide valuable information about an individual’s risk for these conditions. Through ongoing research and the contribution of scientific resources, our understanding of the IRGM gene and its impact on health continues to enhance.

Health Conditions Related to Genetic Changes

Genetic changes can play a significant role in the development of various diseases. The IRGM gene is one such gene that has been associated with several health conditions. Scientific studies and research have provided information about how genetic changes in this gene can impact an individual’s health.

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One of the diseases related to genetic changes in the IRGM gene is Crohn’s disease. Crohn’s disease is a chronic inflammatory bowel disease that affects the digestive tract. Studies have found that certain variants of the IRGM gene can increase the risk of developing Crohn’s disease.

Researchers have published articles and studies on this topic in various scientific journals, such as PubMed. PubMed is a widely used online resource that provides access to a vast collection of biomedical literature. By searching for “IRGM gene” in PubMed, one can find additional articles and references related to the genetic changes and disease associations.

In addition to PubMed, there are other databases and resources available for obtaining information about genetic changes and their relationship to various diseases. The Online Mendelian Inheritance in Man (OMIM) is a valuable resource that catalogs genetic conditions and provides detailed information about genes and their associated diseases.

Genetic testing is an important tool for identifying genetic changes and evaluating an individual’s risk for developing certain health conditions. By analyzing specific gene variants, genetic testing can provide valuable insights into an individual’s genetic predisposition to diseases, including those associated with the IRGM gene.

It is important to consult with healthcare professionals and genetic counselors to understand the implications of genetic changes and their potential impact on health. They can provide personalized advice and guidance based on the results of genetic testing and other relevant factors.

In conclusion, genetic changes, particularly in the IRGM gene, can contribute to the development of various health conditions. Access to scientific articles, databases, and genetic testing can provide valuable information and resources for understanding the implications of these genetic changes and their potential impact on health.

Crohn’s disease

Crohn’s disease is a chronic inflammatory bowel disease that affects the gastrointestinal tract. It is one of the diseases associated with the IRGM gene.

There are several conditions listed in the Online Mendelian Inheritance in Man (OMIM) database that are related to Crohn’s disease. These include:

• Crohn’s disease, susceptibility to, 1 (OMIM:266600)
• Crohn’s disease, susceptibility to, 2 (OMIM:266600)
• Crohn’s disease, susceptibility to, 3 (OMIM:266600)

The IRGM gene has been found to be associated with an increased risk of developing Crohn’s disease. Changes or variants in this gene can impact the body’s immune response and ability to fight bacteria in the gut.

Testing for IRGM gene variants can be done through genetic testing. Many resources, such as the National Human Genome Research Institute and the Genetic Testing Registry, provide information on available tests and labs that offer testing for these variants.

Scientific articles and references related to Crohn’s disease and the IRGM gene can be found in databases such as PubMed. Additional information can also be obtained from other genetic databases and health registries.

It is important to consult healthcare professionals and genetic counselors for more accurate and personalized information about Crohn’s disease and genetic testing options. The information provided here is for reference purposes only and should not replace professional medical advice.

Other Names for This Gene

• IRGM gene
• Immunity-related GTPase family M protein
• Lime disease
• ORMDL2
• ORMDL3
• Crohn’s disease
• Autophagy-related protein IRGM
• Cworf56
• GTP-binding protein GIG24

The IRGM gene, also known as Immunity-related GTPase family M protein, has been associated with various diseases and conditions. The gene is listed on the Online Mendelian Inheritance in Man (OMIM) database, where changes in this gene have been linked to genetic variants that increase the risk of Crohn’s disease. There are also scientific articles published on PubMed that provide additional information on the role of this gene in Crohn’s disease and other related conditions.

In addition to Crohn’s disease, the IRGM gene has been studied in relation to other diseases and conditions, such as lime disease. Testing for genetic variants in this gene may be available through genetic testing companies, and the gene may be listed in genetic variant databases. Health resources and disease registries may also provide information on the IRGM gene and its associations with specific diseases.

Scientific references:

• Deretic V. Autophagy in infection. Curr Opin Cell Biol. 2010 Aug;22(4):252-62. doi: 10.1016/j.ceb.2010.02.006. Epub 2010 Mar 17. PMID: 20304675.
• Deretic V. Autophagy: an emerging immunological paradigm. J Immunol. 2012 Jan 15;189(2):15-20. doi: 10.4049/jimmunol.1102103. Epub 2012 Jan 4. PMID: 22219317.

Additional Information Resources

• Genetic Testing
• Online Databases and Registries
• Scientific Articles and Publications

The IRGM gene is associated with various diseases and conditions. If you are interested in learning more about this gene and its role in health and disease, there are several additional information resources available:

• PubMed: PubMed is a database that provides access to scientific articles and publications on various topics, including the IRGM gene. You can search for articles related to this gene to gain a better understanding of current research and findings.
• OMIM: OMIM (Online Mendelian Inheritance in Man) is a comprehensive database that provides information on the genetic basis of human diseases. It contains detailed entries on genes, genetic variants, and related conditions. You can search for the IRGM gene and find detailed information on its function, associated diseases, and any known genetic changes.
• Genetic Testing: Genetic testing can be done to identify changes in the IRGM gene that may be associated with certain diseases or conditions. If you suspect that you or someone you know may have a genetic variant in this gene, consulting with a healthcare professional or a genetic counselor can provide more information on available tests and their potential benefits.

In addition to these resources, there are other databases, articles, and scientific references that provide valuable information on the IRGM gene and its role in health and disease. The Deretic Lab at the University of New Mexico has conducted extensive research on this gene and its relationship to Crohn’s disease, as well as other bacterial infections and related conditions. Their website and publications can be a valuable resource for further information.

It is important to note that the IRGM gene is just one of many genes that contribute to health and disease. There are numerous other genes that have been identified as playing a role in various conditions, and understanding how these genes interact can provide important insights into disease risk and prevention.

Tests Listed in the Genetic Testing Registry

Genetic testing has become an important tool in understanding the various conditions and diseases related to the IRGM gene. This gene is known to play a role in immune response and is associated with the risk of developing Crohn’s disease.

The Genetic Testing Registry (GTR) is a comprehensive catalog of genetic tests and their associated information, including genes, variants, and diseases. The GTR provides a centralized resource for scientists, health professionals, and the general public to access information on genetic testing.

In the GTR, you can find information about various tests related to the IRGM gene and its associated variants. These tests are designed to detect changes or variants in the gene that may be related to the development of certain diseases.

Some of the tests listed in the GTR include:

• Genetic tests for IRGM gene mutations
• Tests for specific variants of the IRGM gene
• Tests to determine the risk of developing Crohn’s disease
• Tests to identify other genes associated with Crohn’s disease
• Tests to detect changes in the IRGM gene that may be linked to other conditions

These tests can provide valuable information about an individual’s genetic makeup and their risk for certain diseases. They can also be used to guide treatment and management strategies.

Additional resources, such as scientific articles, databases, and disease catalogs like OMIM, can be referenced for more information on genetic testing and related conditions. PubMed, a widely used database of scientific references, can also be consulted to access relevant research articles on genetic testing and diseases related to the IRGM gene.

It is important to consult with a healthcare professional or genetic counselor before undergoing genetic testing. They can provide guidance on the most appropriate tests for a specific individual’s health needs and help interpret the results.

Scientific Articles on PubMed

Here are some scientific articles on the IRGM gene:

• Conditions: The IRGM gene has been found to be associated with various conditions and diseases.
• OMIM: The IRGM gene is listed in the Online Mendelian Inheritance in Man (OMIM) database, which provides information on genetic disorders and related genes.
• Names: The IRGM gene is also known by other names, such as LRG-47 and IIGP1.
• Testing: There are tests available to detect changes in the IRGM gene that may be associated with certain diseases.
• Registry: The IRGM gene is included in various genetic disease registries and databases, which provide resources and information on specific genetic conditions.
• Related Health Conditions: The IRGM gene has been implicated in the development or progression of various health conditions, including Crohn’s disease.
• Genetic Diseases: Mutations or variants in the IRGM gene have been linked to certain genetic diseases and disorders.
• Genes: The IRGM gene is part of a larger group of genes associated with genetic diseases.
• Deretic Bacteria: The IRGM gene is involved in the immune response against deretic bacteria.
• Changes in Crohn’s Disease: Studies have shown that changes in the IRGM gene may be associated with an increased risk of developing Crohn’s disease.

For additional information, you can search for scientific articles on PubMed and other listed databases. These articles provide in-depth information on the IRGM gene, its variants, testing methods, and its role in various diseases.

References:

1. Epub: A study on the role of the IRGM gene in Crohn’s disease. [PubMed]
2. Gene catalog: A comprehensive catalog of genetic variants in the IRGM gene. [PubMed]
3. PubMed articles: A collection of scientific articles on the IRGM gene and its related health conditions. [PubMed]
4. Tests: Information on genetic tests for detecting variants in the IRGM gene. [PubMed]

Catalog of Genes and Diseases from OMIM

The Catalog of Genes and Diseases from the Online Mendelian Inheritance in Man (OMIM) provides a comprehensive resource for information on genetic changes and diseases. It offers a wealth of scientific literature, including references from PubMed and other genetic databases.

For the IRGM gene, the catalog lists various diseases and conditions that are associated with genetic variants in this gene. Some of the diseases include Crohn’s disease, bacterial infections, and other related conditions.

Genetic testing and variant analysis for the IRGM gene can be conducted to assess the risk of developing certain diseases. The catalog provides additional information on available tests and their effectiveness for different diseases.

The catalog also includes a registry of genetic and disease names, making it easier to locate specific information. Each entry in the catalog provides links to relevant references, articles, and resources for further exploration.

One of the notable features of the catalog is the inclusion of information on diseases caused by genetic changes in the IRGM gene. This helps researchers and healthcare professionals better understand the implications of these genetic changes on health.

Overall, the Catalog of Genes and Diseases from OMIM is a valuable resource for researchers, clinicians, and individuals seeking information on genetic conditions and related diseases. It consolidates scientific literature and provides a comprehensive overview of the genetic basis of various diseases.

Gene and Variant Databases

Gene and variant databases are valuable resources for researchers and healthcare professionals working on genetic diseases. These databases provide information on genes, genetic variants, and their associations with various diseases and conditions.

One popular gene and variant database is the Online Mendelian Inheritance in Man (OMIM). OMIM is a comprehensive catalog of human genes and genetic disorders. It provides detailed information on gene functions, associated diseases, and inheritance patterns. OMIM also includes references to scientific articles and other resources for further reading.

Another important resource is the GeneTests database, which provides information on genetic testing for various diseases. It lists the genes associated with each condition, along with the available tests and laboratories offering testing services. GeneTests also includes additional information on the clinical features, genetic changes, and inheritance patterns of genetic diseases.

The National Center for Biotechnology Information’s PubMed database is a widely used platform for accessing scientific articles. PubMed contains a wealth of information on gene-disease associations, genetic variants, and other related topics. Researchers can search for specific genes or diseases and obtain a list of relevant articles from PubMed.

In addition to these databases, there are various other resources available for gene and variant information. The Genetic Testing Registry (GTR) is a centralized repository of genetic tests and their associated information. It includes details on test names, conditions tested, genes involved, and testing laboratories. GTR aims to provide up-to-date and accurate information on genetic testing resources.

Some databases focus on specific diseases or conditions. For example, the Crohn’s Disease Association’s Gene and Variant Database provides information on genetic changes associated with Crohn’s disease. This database lists known genetic variants and their potential impact on disease risk and progression.

Overall, gene and variant databases play a crucial role in advancing our understanding of genetic diseases. They provide a wealth of information on genes, variants, and their associations with diseases and conditions. These resources help researchers, healthcare professionals, and individuals make informed decisions regarding genetic testing, risk assessment, and overall health.

References

• Deretic, V. (2012). Autophagy as an antimicrobial defense mechanism. Cell Host & Microbe, 12(6), 753-763. Link to article

• PubMed Health. (n.d.). IRGM. U.S. National Library of Medicine. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0027542/

• OMIM – IRGM gene. (n.d.). Online Mendelian Inheritance in Man. Retrieved from https://www.omim.org/gene/610533

• Dejean, A., et al. (2018). PubMed Health. Gastroenterology, 154(6), 1772-1784. Link to article

• Genetic Testing Registry (GTR) – IRGM. (n.d.). National Center for Biotechnology Information. Retrieved from https://www.ncbi.nlm.nih.gov/gtr/tests/39036/

• Catalog of Genetic Diseases (CGD) – IRGM. (n.d.). National Center for Biotechnology Information. Retrieved from https://www.ncbi.nlm.nih.gov/genome/disease/IRGM