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The WNK4 gene, also known as the WNK lysine deficient protein kinase 4 gene, is a key gene involved in the regulation of blood pressure and electrolyte balance in the body. It plays a crucial role in the reabsorption of sodium and potassium ions in the kidneys, which in turn affects blood pressure.

WNK4 gene changes and variants have been associated with various disorders, including pseudohypoaldosteronism type 2 and other genetic forms of hypertension. Mutations in this gene can lead to increased sodium reabsorption, resulting in increased blood pressure and fluid retention.

There are several resources available for genetic testing of the WNK4 gene. The Online Mendelian Inheritance in Man (OMIM) database provides comprehensive information on the genetic basis of diseases. The National Center for Biotechnology Information (NCBI) also offers a catalog of genetic variants and related scientific articles in its PubMed database, which can provide additional references for further research on WNK4 gene-related conditions and disorders.

Genetic changes in the WNK4 gene have been associated with various health conditions and diseases. These changes can result in the development of pseudohypoaldosteronism type 2 (PHA2), a rare genetic disorder that affects the body’s ability to regulate salt reabsorption in the kidneys.

Pseudohypoaldosteronism type 2 is characterized by an increased salt reabsorption in the kidneys, which can lead to high blood pressure and electrolyte imbalances. Individuals with this condition may experience symptoms such as hypertension, low blood potassium levels, and metabolic alkalosis.

To diagnose pseudohypoaldosteronism type 2, genetic testing of the WNK4 gene can be performed. This testing can identify specific genetic changes or variants in the WNK4 gene that contribute to the development of the condition. The results from this testing can provide valuable information for proper diagnosis and management of affected individuals.

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There are several resources available for accessing information on genetic changes in the WNK4 gene and related health conditions. The Online Mendelian Inheritance in Man (OMIM) database is a comprehensive catalog of genes and genetic disorders and provides detailed information on the WNK4 gene and its associated health conditions.

In addition to OMIM, scientific articles and publications on the WNK4 gene and related conditions can be found in PubMed, a free resource for accessing scientific literature. Genetic databases such as the Human Gene Mutation Database (HGMD) and the Genetic Testing Registry (GTR) also list genetic changes and variants associated with the WNK4 gene.

Healthcare professionals can use these resources to stay updated on the latest research and findings regarding genetic changes in the WNK4 gene and pseudohypoaldosteronism type 2. This information can aid in the diagnosis, treatment, and management of individuals with these conditions.

It is important for individuals with a family history of pseudohypoaldosteronism type 2 or related health conditions to undergo genetic testing and screening. This can help identify any genetic changes or variants in the WNK4 gene that may be present and allow for early detection and intervention.

In summary, genetic changes in the WNK4 gene have been linked to pseudohypoaldosteronism type 2 and related health conditions. Through genetic testing and the resources mentioned above, healthcare professionals and individuals can access valuable information on these conditions and ensure appropriate management and care.

Pseudohypoaldosteronism type 2

Pseudohypoaldosteronism type 2 is a genetic disorder related to the WNK4 gene. It is a complex condition that affects the body’s ability to properly regulate sodium reabsorption.

See also  PIGA gene

This condition is also known by other names, including Gordon syndrome, familial hyperkalemia-hypertension syndrome, and familial hyperkalemic hypertension.

There are several free scientific articles available on this topic in databases such as PubMed and OMIM. These articles provide additional information on the genetic changes and related conditions associated with pseudohypoaldosteronism type 2.

Genetic testing can be performed to identify changes in the WNK4 gene that may be associated with this condition. This testing can help in the diagnosis of pseudohypoaldosteronism type 2 and can also provide information on the genetic variants that may be present.

In addition to the WNK4 gene, there are other genes and genetic changes that have been identified in relation to pseudohypoaldosteronism and related disorders. These changes can cause an increased or decreased reabsorption of sodium in the body, leading to changes in blood pressure and other health conditions.

For more information on pseudohypoaldosteronism type 2, you can refer to the catalog of genetic disorders at the National Institutes of Health’s Genetic Testing Registry.

References:

  • Article 1: provides information on the genetic changes associated with pseudohypoaldosteronism type 2
  • Article 2: discusses the clinical features of this condition and potential treatment options
  • Article 3: explores the genetic variants and their impact on sodium reabsorption

Other disorders

Changes in the WNK4 gene have been associated with various other disorders. Here is a catalog of other conditions and genetic variants related to the WNK4 gene:

  • Pseudohypoaldosteronism type 2 (PHA2): Increased reabsorption of salt by the kidneys and increased blood pressure.
  • Other genetic disorders: WNK4 gene changes have been identified in other genetic diseases, but more research is needed to fully understand their implications.

It is important to consult health professionals for proper testing and diagnosis of any genetic changes or related disorders. The following resources provide additional information and databases for genetic testing and related conditions:

  1. PubMed: A comprehensive database of scientific publications and references on genetic studies.
  2. OMIM: Online Mendelian Inheritance in Man (OMIM) provides detailed information on genetic disorders and genes.
  3. Genetests: A helpful resource for genetic testing and related information, providing access to free testing, research articles, and more.
  4. NCBI Genetic Testing Registry (GTR): A database that provides information on genetic tests and laboratories.

These resources can help individuals and healthcare professionals gather more information about the WNK4 gene and its related disorders.

Other Names for This Gene

  • The WNK4 gene is also known as:
    • Pseudohypoaldosteronism type II
    • Genetic hypertension, WNK4-related
    • Increased blood pressure, genetic, WNK4-related
    • WNK4
  • This gene is listed in the Genetic Testing Registry (GTR) as WNK4 (WNK lysine deficient protein kinase 4).
  • Other names and related genes include:
    • Pseudohypoaldosteronism type II, increased renal salt reabsorption
    • Genes for complex diseases on which WNK4 gene has been reported
  • There have been changes in the names and symbols of this gene over the years. For more information, refer to the following sources:
  1. Online Mendelian Inheritance in Man (OMIM)
  2. Scientific articles
  3. Free available resources
  4. Publications from PubMed
  5. Additional changes in the names and symbols can be found in catalogs, health condition tests, and databases.

Additional Information Resources

The WNK4 gene is associated with various health conditions and disorders. If you are interested in learning more about this gene and its role in these conditions, the following resources provide additional information:

  • OMIM (Online Mendelian Inheritance in Man): OMIM is a comprehensive catalog of human genes and genetic disorders. You can search for the WNK4 gene and find detailed information about its structure, functions, and associated diseases.
  • PubMed: PubMed is a database of scientific articles in the field of medicine and biomedical research. Searching for “WNK4 gene” or related terms will provide you with scientific studies and articles that have been published on this topic.
  • Genetic Testing: Genetic testing can be performed to detect changes or variants in the WNK4 gene. These tests can provide valuable information about your genetic profile and potential health risks.
  • Pseudohypoaldosteronism Type 2 Registry: The Pseudohypoaldosteronism Type 2 Registry collects and analyzes data related to this rare genetic condition. They can provide further information about the WNK4 gene and its role in pseudohypoaldosteronism.
  • Other Genetic Databases: There are various other genetic databases and registries that provide information about the WNK4 gene and its associated conditions. These resources can be valuable sources of complex and specialized information.
See also  F7 gene

These resources can help you understand the role of the WNK4 gene in various health conditions and provide you with additional information for further research.

Tests Listed in the Genetic Testing Registry

There have been various tests listed in the Genetic Testing Registry (GTR) related to the WNK4 gene and its changes. These tests primarily focus on genetic changes in the WNK4 gene that have been associated with pseudohypoaldosteronism type 2 (PHA2), a rare genetic disorder characterized by increased blood pressure and decreased potassium reabsorption in the kidneys.

Genetic testing for the WNK4 gene can provide valuable information regarding the specific variant or changes in the gene that may be contributing to the development of pseudohypoaldosteronism type 2. This testing can help in the diagnosis of this condition and aid in the management and treatment approaches.

The Genetic Testing Registry is a comprehensive registry that provides information on a wide range of genetic tests. It offers a wealth of resources for health professionals and individuals seeking information on genetic testing for various conditions and diseases.

The GTR includes references to scientific articles, databases, and other resources related to genetic testing for pseudohypoaldosteronism type 2 and other related conditions. These resources can provide additional information on the genetic changes, testing methods, and associated health conditions.

For further information and references, you can explore the GTR and other databases such as OMIM (Online Mendelian Inheritance in Man), PubMed, and other scientific catalogs and resources on genetic diseases and disorders.

In conclusion, the Genetic Testing Registry provides a valuable repository of tests related to the WNK4 gene and its changes that have been associated with increased blood pressure and pseudohypoaldosteronism type 2. Health professionals and individuals can access this registry to find information on genetic testing options, references, and other resources related to this condition.

Scientific Articles on PubMed

Scientific articles on PubMed provide valuable information about the WNK4 gene and its role in various diseases and genetic conditions. These articles focus on topics such as reabsorption, genetic testing, and changes in the body.

The WNK4 gene is associated with pseudohypoaldosteronism, a complex disorder characterized by changes in the body’s electrolyte balance and blood pressure regulation. This gene variant can lead to increased reabsorption of sodium and chloride in the kidneys, affecting the body’s fluid balance.

PubMed is a comprehensive catalog of scientific articles and references from various databases, providing a wealth of information on genetic conditions, genes, and other related topics.

Some of the scientific articles on PubMed provide information on the testing and diagnosis of pseudohypoaldosteronism and other WNK4 gene-related disorders. They discuss the clinical features, diagnostic criteria, and available tests for these conditions.

The articles also list the names of other genes associated with pseudohypoaldosteronism and related disorders, highlighting the complexity of these conditions and the involvement of multiple genes.

In addition to pseudohypoaldosteronism, PubMed articles cover a wide range of genetic conditions and diseases. They provide insights into the genetic basis of various disorders, offering valuable information for genetic testing and counseling.

References from PubMed articles can help researchers and healthcare professionals stay updated with the latest scientific advancements in the field of genetic health. They serve as a valuable resource for additional information and further research.

OMIM is another important database referenced in PubMed articles. It provides detailed information on genetic disorders, including pseudohypoaldosteronism and other conditions associated with the WNK4 gene.

In summary, scientific articles on PubMed offer a wealth of information on the WNK4 gene, its role in pseudohypoaldosteronism and other disorders, and related genetic testing. Researchers and healthcare professionals can rely on PubMed as a reliable source for up-to-date scientific information on these topics.

See also  Léri-Weill dyschondrosteosis

Catalog of Genes and Diseases from OMIM

The OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic disorders. It provides a valuable resource for researchers, clinicians, and individuals interested in genetic conditions and their associated genes.

One of the genetic disorders listed in the OMIM is pseudohypoaldosteronism type 2. This condition is characterized by increased salt reabsorption in the body, which leads to elevated blood pressure.

The WNK4 gene, also known as the WNK lysine deficient protein kinase 4 gene, is associated with pseudohypoaldosteronism type 2. Mutations in this gene can lead to changes in the function of the WNK4 protein, which affects salt reabsorption in the kidneys.

In addition to the WNK4 gene, the OMIM catalog includes information on other genes related to pseudohypoaldosteronism and a variety of other genetic disorders. The catalog provides detailed information on the genetic variants associated with each disorder, as well as references to scientific articles and additional resources for further reading.

The OMIM catalog is a valuable tool for genetic testing laboratories and healthcare providers. It allows them to access up-to-date information on the genetic basis of various diseases and to perform accurate diagnostic tests for these conditions.

References:

This article highlights the catalog of genes and diseases available from OMIM, with a focus on the genetic disorder pseudohypoaldosteronism type 2 and its associated gene, WNK4. It emphasizes the importance of the OMIM catalog as a valuable resource for genetic research and healthcare professionals.

Gene and Variant Databases

When studying the WNK4 gene and its variants, it is important to consult various gene and variant databases. These databases serve as valuable resources for researchers and healthcare professionals in understanding the genetic basis of certain conditions and diseases.

One of the databases commonly used is the Online Mendelian Inheritance in Man (OMIM) database. OMIM provides comprehensive information about genes and genetic conditions, including pseudohypoaldosteronism type 2 related to the WNK4 gene. It lists the names of related genes, variant changes, genetic tests, and references to scientific articles. This database is a reliable source of information for studying WNK4 and its association with pseudohypoaldosteronism.

Another important resource is the Genetic Testing Registry (GTR), which is a centralized online catalog of genetic tests. This registry provides information about different types of tests available for WNK4 gene variants and their associated disorders. It also includes information about laboratories and healthcare providers offering these tests. The GTR is a useful tool for healthcare providers and individuals seeking genetic testing for WNK4 gene-related conditions.

In addition to OMIM and GTR, there are other databases and resources that can provide further information about the WNK4 gene and its variants. PubMed, a comprehensive database of scientific articles, can be searched for relevant research articles and publications on WNK4 genetic changes and their implications. Various genetic and health-related organizations also maintain databases and resources specific to certain conditions and diseases, which may include information on WNK4 gene variants. These resources can provide additional insights into the role of WNK4 in complex genetic conditions and related disorders.

In summary, when studying the WNK4 gene and its variants, it is important to consult gene and variant databases such as OMIM and GTR. These databases provide valuable information on genetic changes, associated disorders, genetic testing, and scientific references. Additional resources such as PubMed and specialty databases can further enhance our understanding of the WNK4 gene and its implications in various diseases and conditions.

References

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